Anto P. Rajkumar
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View article: A Data‐driven Approach for Genetic Prediction of Alzheimer's Diseases when Polygenic RiskScores Fail to account AD's Genetic Complexity
A Data‐driven Approach for Genetic Prediction of Alzheimer's Diseases when Polygenic RiskScores Fail to account AD's Genetic Complexity Open
Background Alzheimer's Disease (AD) is the primary cause of cognitive decline in individuals. Early diagnosis of AD is significantly difficult because of its complex pathogenesis and overlap with symptoms of aging, yet crucial for early tr…
View article: Diagnostic biomarker potential of plasma small extracellular vesicle RNA enriched for microglial origin in people with Dementia with Lewy bodies
Diagnostic biomarker potential of plasma small extracellular vesicle RNA enriched for microglial origin in people with Dementia with Lewy bodies Open
Background Accurate distinction between Dementia with Lewy Bodies (DLB) and Alzheimer's Disease (AD) is important because they differ in their prognosis, risk profiles, and treatment. As current radioisotopes‐based imaging biomarkers for D…
View article: Cellular and Extracellular MicroRNA Dysregulation in LRRK2-Linked Parkinson’s Disease
Cellular and Extracellular MicroRNA Dysregulation in LRRK2-Linked Parkinson’s Disease Open
Cell-free microRNAs in body fluids have emerged as promising biomarker candidates in neurodegenerative diseases. While several studies have identified dysregulated miRNAs in sporadic Parkinson’s disease, it remains unclear whether distingu…
View article: Improving access to physical healthcare for older people in mental health settings: the ImPreSs-care qualitative study
Improving access to physical healthcare for older people in mental health settings: the ImPreSs-care qualitative study Open
Background Older people with serious mental ill health have high levels of physical comorbidity. Despite this, mental health services receive limited physical health support from primary or secondary care. This study investigated the facil…
View article: Cellular and Extracellular microRNA Dysregulation in LRRK2-Linked Parkinson’s Disease
Cellular and Extracellular microRNA Dysregulation in LRRK2-Linked Parkinson’s Disease Open
Background and objective The discovery of cell-free micro-RNAs in body fluids has made them a promising biomarker target in the field of neurodegenerative diseases. Although they have been reported to be differentially expressed in bioflui…
View article: Systematic review of the efficacy of pharmacological and non-pharmacological interventions for improving quality of life of people with dementia
Systematic review of the efficacy of pharmacological and non-pharmacological interventions for improving quality of life of people with dementia Open
Background People with dementia (PwD) and their carers often consider maintaining good quality of life (QoL) more important than improvements in cognition or other symptoms of dementia. There is a clinical need for identifying intervention…
View article: Systematic review of differentially abundant proteins in people with Lewy body dementia
Systematic review of differentially abundant proteins in people with Lewy body dementia Open
Objectives: Dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) are collectively called as Lewy body dementia (LBD). Despite the urgent clinical need, there is no reliable protein biomarker for LBD. Hence, we conducted t…
View article: Transcriptome-wide alternative splicing and transcript-level differential expression analysis of post-mortem Lewy body dementia brains
Transcriptome-wide alternative splicing and transcript-level differential expression analysis of post-mortem Lewy body dementia brains Open
Lewy body dementias (LBD) are the second most common dementia. Several genes have been associated with LBD, but little is known about their contributions to LBD pathophysiology. Each gene may transcribe multiple RNA, and LBD brains have ex…
View article: The cellular and extracellular proteomic signature of human dopaminergic neurons carrying the LRRK2 G2019S mutation
The cellular and extracellular proteomic signature of human dopaminergic neurons carrying the LRRK2 G2019S mutation Open
Background Extracellular vesicles are easily accessible in various biofluids and allow the assessment of disease-related changes in the proteome. This has made them a promising target for biomarker studies, especially in the field of neuro…
View article: The Cellular and Extra-Cellular Proteomic Signature of Human Dopaminergic Neurons Carrying the LRRK2 G2019S Mutation
The Cellular and Extra-Cellular Proteomic Signature of Human Dopaminergic Neurons Carrying the LRRK2 G2019S Mutation Open
Extracellular vesicles are easily accessible in various biofluids and allow the assessment of disease-related changes of the proteome. This has made them a promising target for biomarker studies, especially in the field of neurodegeneratio…
View article: Integrated Physical‐Mental Healthcare Services in Specialist Settings to Improve Outcomes for Older People Living With Mental Health Diagnoses: A Systematic Review
Integrated Physical‐Mental Healthcare Services in Specialist Settings to Improve Outcomes for Older People Living With Mental Health Diagnoses: A Systematic Review Open
Background Many older people are now living with co‐occurring physical and mental health disorders, but these often managed separately. The aim of this systematic review was to explore integrated physical‐mental health care services availa…
View article: Monitoring Initiation and Administration of Covert Medication(s) for Service Users in Amber Ward of Millbrook Mental Health Unit, Nottinghamshire Healthcare NHS Foundation Trust: A Re-Audit of Compliance With Maudsley Prescribing Guidelines in Psychiatry
Monitoring Initiation and Administration of Covert Medication(s) for Service Users in Amber Ward of Millbrook Mental Health Unit, Nottinghamshire Healthcare NHS Foundation Trust: A Re-Audit of Compliance With Maudsley Prescribing Guidelines in Psychiatry Open
Aims 1. To evaluate standards of practice regarding initiation and administration of covert medication(s), with comparison to the previous audit completed in January 2021. 2. To highlight improvements and weaknesses requiring further recom…
View article: Dementia with Lewy Bodies: Genomics, Transcriptomics, and Its Future with Data Science
Dementia with Lewy Bodies: Genomics, Transcriptomics, and Its Future with Data Science Open
Dementia with Lewy bodies (DLB) is a significant public health issue. It is the second most common neurodegenerative dementia and presents with severe neuropsychiatric symptoms. Genomic and transcriptomic analyses have provided some insigh…
View article: Differential expression of 5mC epigenomic regulators in Alzheimer’s disease
Differential expression of 5mC epigenomic regulators in Alzheimer’s disease Open
Background Epigenetic processes are molecular mechanisms that contribute to the pathogenesis of neurodegenerative diseases. 5‐methylcytosine (5mC) and the oxidised state, 5‐formilcytosine (5fC), are known transcriptional regulators moderat…
View article: Artificial intelligence for biomarker discovery in Alzheimer's disease and dementia
Artificial intelligence for biomarker discovery in Alzheimer's disease and dementia Open
With the increase in large multimodal cohorts and high‐throughput technologies, the potential for discovering novel biomarkers is no longer limited by data set size. Artificial intelligence (AI) and machine learning approaches have been de…
View article: Extracellular vesicle microRNA-mediated transcriptional regulation may contribute to dementia with Lewy bodies molecular pathology
Extracellular vesicle microRNA-mediated transcriptional regulation may contribute to dementia with Lewy bodies molecular pathology Open
Objective: Dementia with Lewy bodies (DLB) is the second most common dementia. Advancing our limited understanding of its molecular pathogenesis is essential for identifying novel biomarkers and therapeutic targets for DLB. DLB is an α-syn…
View article: Correlates of poor clinical outcomes related to COVID-19 among older people with psychiatric illness - a mixed methods study
Correlates of poor clinical outcomes related to COVID-19 among older people with psychiatric illness - a mixed methods study Open
Objective COVID-19 may lead to a range of clinical outcomes among older people with psychiatric and medical conditions. Evidence guiding management of future outbreaks among this vulnerable population in psychiatric hospital settings are s…
View article: Differential expression of m5C RNA methyltransferase genes NSUN6 and NSUN7 in Alzheimer’s disease and Traumatic Brain Injury
Differential expression of m5C RNA methyltransferase genes NSUN6 and NSUN7 in Alzheimer’s disease and Traumatic Brain Injury Open
Epigenetic processes have become increasingly relevant in understanding disease modifying mechanisms. 5-methylcytosine methylation of DNA (5mC) and RNA (m 5 C) have functional transcriptional and RNA translational consequences and are tigh…
View article: Differential expression of m5C RNA methyltransferase genes NSUN6 and NSUN7 in Alzheimer’s disease and Traumatic Brain Injury
Differential expression of m5C RNA methyltransferase genes NSUN6 and NSUN7 in Alzheimer’s disease and Traumatic Brain Injury Open
Epigenetic processes have become increasingly relevant in understanding disease modifying mechanisms. 5-methylcytosine methylation of DNA (5mC) and RNA (m 5 C) have functional transcriptional and RNA translational consequences and are tigh…
View article: Systematic review of pharmacological interventions for people with Lewy body dementia
Systematic review of pharmacological interventions for people with Lewy body dementia Open
Supplemental data for this article can be accessed online at https://doi.org/10.1080/13607863.2022.2032601 .
View article: Correction: An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels
Correction: An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels Open
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View article: An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels
An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels Open
This international guideline proposes improving clozapine package inserts worldwide by using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest that clozapine is the third most toxic drug in the United State…
View article: Perspectives of GCSE students attending a psychiatry summer school in south London
Perspectives of GCSE students attending a psychiatry summer school in south London Open
Aims and Method This study evaluated a pilot psychiatry summer school for GCSE students in terms of participant experience, effects on attitudes to mental illness and perception of psychiatry as a career option. This was done using the Com…
View article: An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders
An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders Open
Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology at the earliest stage of some neurodegenerative disorders, but do not have the scalability needed for population screening. Therefore, a blood-based …
View article: Systematic review of gene expression studies in people with Lewy body dementia
Systematic review of gene expression studies in people with Lewy body dementia Open
Objectives: Lewy body dementia (LBD) is the second most prevalent neurodegenerative dementia and it causes more morbidity and mortality than Alzheimer’s disease. Several genetic associations of LBD have been reported and their functional i…
View article: Systematic review of genetic association studies in people with Lewy body dementia
Systematic review of genetic association studies in people with Lewy body dementia Open
Objectives Lewy body dementia (LBD) causes more morbidity, disability, and earlier mortality than Alzheimer disease. Molecular mechanisms underlying neurodegeneration in LBD are poorly understood. We aimed to do a systematic review of all …