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View article: Tissue-resident macrophages co-develop with myocardial tissue in human induced pluripotent stem cell-derived organoids
Tissue-resident macrophages co-develop with myocardial tissue in human induced pluripotent stem cell-derived organoids Open
The heart is the first functional organ to develop during embryogenesis, forming in parallel with the vasculature and hematopoietic cell lineages. To advance our understanding of human cardiac development and disease, human induced pluripo…
View article: Tissue resident macrophages innately develop in a human iPSC-derived cardiac organoid model
Tissue resident macrophages innately develop in a human iPSC-derived cardiac organoid model Open
The heart is the first functional organ to develop during embryogenesis, forming in parallel with the vasculature and hematopoietic cell lineages. To advance our understanding of human cardiac development and disease, human induced pluripo…
View article: Multiorgan Dysfunction and its Association With Congestion and Outcome in Aortic Stenosis Treated With TAVI
Multiorgan Dysfunction and its Association With Congestion and Outcome in Aortic Stenosis Treated With TAVI Open
Biomarker abnormalities are highly prevalent in severe AS, influenced by congestion, and associated with impaired prognosis post-TAVI. Multiorgan dysfunction faces a particularly dismal outcome.
View article: Management of Fluid Overload in Patients With Severe Aortic Stenosis (EASE-TAVR)
Management of Fluid Overload in Patients With Severe Aortic Stenosis (EASE-TAVR) Open
In patients with severe AS and concomitant FO, quantitatively guided decongestive treatment and associated intensified management post-TAVR was associated with improved outcomes and quality of life compared to decongestion by clinical judg…
View article: Erzeugung menschlicher Nervengewebe in der Kulturschale
Erzeugung menschlicher Nervengewebe in der Kulturschale Open
Multiple protocols for organoid models of the human brain were developed over the last decade, representing different brain regions. Co-cultures of these organoids, referred to as assembloids, have further increased the complexity of these…
View article: Neuro-mesodermal assembloids recapitulate aspects of peripheral nervous system development in vitro
Neuro-mesodermal assembloids recapitulate aspects of peripheral nervous system development in vitro Open
Here we describe a novel neuro-mesodermal assembloid model that recapitulates aspects of peripheral nervous system (PNS) development such as neural crest cell (NCC) induction, migration, and sensory as well as sympathetic ganglion formatio…
View article: Neuro-mesodermal assembloids recapitulate aspects of peripheral nervous system development<i>in vitro</i>
Neuro-mesodermal assembloids recapitulate aspects of peripheral nervous system development<i>in vitro</i> Open
Here we describe a novel neuro-mesodermal assembloid model which recapitulates aspects of peripheral nervous system (PNS) development such as neural crest cell (NCC) induction, delamination, migration and sensory as well as sympathetic gan…
View article: A Blood Vessel Organoid Model Recapitulating Aspects of Vasculogenesis, Angiogenesis and Vessel Wall Maturation
A Blood Vessel Organoid Model Recapitulating Aspects of Vasculogenesis, Angiogenesis and Vessel Wall Maturation Open
Blood vessel organoids are an important in vitro model to understand the underlying mechanisms of human blood vessel development and for toxicity testing or high throughput drug screening. Here we present a novel, cost-effective, and easy …
View article: Generation of Vascularized Neural Organoids by Co-culturing with Mesodermal Progenitor Cells
Generation of Vascularized Neural Organoids by Co-culturing with Mesodermal Progenitor Cells Open