Riccardo Rosati
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View article: Staging Laparoscopy in High-Risk Gastric Cancer: A Decade of Real-World Evidence and Therapeutic Impact from a Tertiary Referral Center
Staging Laparoscopy in High-Risk Gastric Cancer: A Decade of Real-World Evidence and Therapeutic Impact from a Tertiary Referral Center Open
Background and Aims: Gastric cancer (GC) remains a leading cause of cancer-related mortality, frequently diagnosed at advanced stages. High-risk features—tumor size ≥ 40 mm, cT3/cT4, nodal involvement, diffuse histology, and Borrmann type …
View article: Endoscopic Ultrasound (EUS)-Based Multimodal Diagnosis of a Rare Intramural Esophageal Squamous Cell Carcinoma: Case Report and Literature Review
Endoscopic Ultrasound (EUS)-Based Multimodal Diagnosis of a Rare Intramural Esophageal Squamous Cell Carcinoma: Case Report and Literature Review Open
Esophageal squamous cell carcinoma (ESCC) is the most prevalent histological subtype of esophageal cancer worldwide, typically manifesting as an endoluminal mass with overt mucosal involvement. Exceptionally, however, ESCC may present with…
View article: First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia
First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia Open
Background Idiopathic achalasia (IA) is characterised by the degeneration of neurons in the myenteric plexus leading to an irreversible impaired oesophageal function. Although immune-mediated mechanisms have been proposed, the underlying a…
View article: Perioperative Outcomes in Open Versus Minimally Invasive Gastrectomy For Gastric Cancer
Perioperative Outcomes in Open Versus Minimally Invasive Gastrectomy For Gastric Cancer Open
Objective: To evaluate morbidity and mortality after minimally invasive (MIG) versus open gastrectomy (OG) for gastric cancer (GC) in a large European population, with a subgroup analysis comparing total and subtotal gastrectomy. Summary B…
View article: Staging laparoscopy for gastric cancer: European consensus
Staging laparoscopy for gastric cancer: European consensus Open
Gastric cancer is the fifth most prevalent cancer and the third most common cause of cancer-related deaths globally1. Gastric cancer frequently metastasizes to the peritoneal cavity. The incidence of peritoneal metastases at the time of di…
View article: Dynamic Prediction of Rectal Cancer Relapse and Mortality Using a Landmarking-Based Machine Learning Model: A Multicenter Retrospective Study from the Italian Society of Surgical Oncology—Colorectal Cancer Network Collaborative Group
Dynamic Prediction of Rectal Cancer Relapse and Mortality Using a Landmarking-Based Machine Learning Model: A Multicenter Retrospective Study from the Italian Society of Surgical Oncology—Colorectal Cancer Network Collaborative Group Open
Background: Almost 30% of patients with rectal cancer (RC) who submit to comprehensive treatment experience relapse. Surveillance plays a leading role in early detection. The landmark approach provides a more flexible and dynamic framework…
View article: The Effect of Intraoperative Hypothermia on Anastomotic Leakage After Esophagectomy
The Effect of Intraoperative Hypothermia on Anastomotic Leakage After Esophagectomy Open
Background/Objectives: Inadvertent intraoperative hypothermia is a common occurrence during major surgery, and some preclinical studies have reported its association with postoperative anastomotic leakage (AL). In the present study, we dem…
View article: Impact of postoperative complications on clinical outcomes after gastrectomy for cancer: multicentre study
Impact of postoperative complications on clinical outcomes after gastrectomy for cancer: multicentre study Open
Background To reduce the clinical and economic burden of complications after gastrectomy for gastric cancer, specific complications should be targeted to effectively allocate healthcare resources for quality improvement and preventive meas…
View article: The Endoscopic Management of Anastomotic Strictures After Esophagogastric Surgery: A Comprehensive Review of Emerging Approaches Beyond Endoscopic Dilation
The Endoscopic Management of Anastomotic Strictures After Esophagogastric Surgery: A Comprehensive Review of Emerging Approaches Beyond Endoscopic Dilation Open
Anastomotic strictures are a common complication following esophagogastric surgery, with prevalence varying depending on the type of surgery and anatomical site. These strictures can lead to debilitating symptoms such as dysphagia, pain, a…
View article: A comprehensive operative risk assessment driving the application of major and emergency surgery in octogenarians
A comprehensive operative risk assessment driving the application of major and emergency surgery in octogenarians Open
Medical decisions driving the clinical management of octogenarians who require either major or urgent surgery still depend on the patient's age rather than individual functions. This report created the privileged opportunity to illustrate …
View article: Mobility Medicine: A call to unify hyper-fragmented specialties by abstracts sent to 2025Pdm3, and typescripts to Ejtm3, and <i>Diagnostics</i>
Mobility Medicine: A call to unify hyper-fragmented specialties by abstracts sent to 2025Pdm3, and typescripts to Ejtm3, and <i>Diagnostics</i> Open
Mega scientific conferences increasingly suffer from the need for short and poster presentations without discussion. An alternative is to organize workshops in hotels large enough to accommodate all participants. This significantly increas…
View article: Pre-Surgical Endoscopic Biopsies Are Representative of Esophageal and Esophago-Gastric Junction Adenocarcinoma Histologic Classes and Survival Risk
Pre-Surgical Endoscopic Biopsies Are Representative of Esophageal and Esophago-Gastric Junction Adenocarcinoma Histologic Classes and Survival Risk Open
Background and Objectives: The Esophageal Adenocarcinoma Study Group Europe (EACSGE) recently proposed a granular histologic classification of esophageal–esophago-gastric junctional adenocarcinomas (EA-EGJAs) based on the study of naïve su…
View article: Endoscopic Management of Post-Esophagectomy Delayed Gastric Conduit Emptying (DGCE): Results from a Cohort Study in a Tertiary Referral Center with Comparison between Procedures
Endoscopic Management of Post-Esophagectomy Delayed Gastric Conduit Emptying (DGCE): Results from a Cohort Study in a Tertiary Referral Center with Comparison between Procedures Open
Background/Objectives: Delayed gastric conduit emptying (DGCE) occurs in 15–39% of patients who undergo esophagectomy. Intra-Pyloric Injection of Botulinum Toxin (IPBT), Pneumatic Balloon Dilation (PBD), and the same session combination (B…
View article: Gender Matters: On Recurrence Risk of Cardiovascular Complications for Type 2 Diabetes Subjects
Gender Matters: On Recurrence Risk of Cardiovascular Complications for Type 2 Diabetes Subjects Open
Background Previous reports suggest that, despite men facing higher absolute risks of cardiovascular complications, women with type 2 diabetes (T2DM) experience greater relative risks of cardiovascular events. Studies prior to 2000 indicat…
View article: Surgical Technique and Implementation of Total Minimally Invasive (Laparo-Thoracoscopic) Ivor Lewis Esophagectomy for Cancer
Surgical Technique and Implementation of Total Minimally Invasive (Laparo-Thoracoscopic) Ivor Lewis Esophagectomy for Cancer Open
Background/Objectives: Esophagectomy represents a major oncological operation due to the surgical involvement of both the abdominal and thoracic cavities. The minimally invasive technique has been developed to minimize the operative impact…
View article: Endoscopic Management of Post-Esophagectomy Delayed-Gastric-Conduit-Emptying (DGCE): Results from a Cohort Study in a Tertiary Referral Center with Comparison between Procedures
Endoscopic Management of Post-Esophagectomy Delayed-Gastric-Conduit-Emptying (DGCE): Results from a Cohort Study in a Tertiary Referral Center with Comparison between Procedures Open
Delayed Gastric Conduit Emptying (DGCE) occurs in 15-39% of patients who underwent esophagectomy. Intra-Pyloric Injection of Botulinum Toxin (IPBT), Pneumatic Balloon Dilation (PBD), and the same session combination (BTPD), represent the m…
View article: Supplementary Tables from Pre-existing immunity drives the response to neoadjuvant chemotherapy in esophageal adenocarcinoma
Supplementary Tables from Pre-existing immunity drives the response to neoadjuvant chemotherapy in esophageal adenocarcinoma Open
Supplementary Table 1. Clinical characteristics of the EAC patients from the prospective cohort (protocol ESO-CA001) Supplementary Table 2. Clinical characteristics of the EAC patients from the additional retrospective cohort selected for …
View article: Supplementary Materials and methods from Pre-existing immunity drives the response to neoadjuvant chemotherapy in esophageal adenocarcinoma
Supplementary Materials and methods from Pre-existing immunity drives the response to neoadjuvant chemotherapy in esophageal adenocarcinoma Open
Supplementary Materials and methods
View article: Supplementary Figures from Pre-existing immunity drives the response to neoadjuvant chemotherapy in esophageal adenocarcinoma
Supplementary Figures from Pre-existing immunity drives the response to neoadjuvant chemotherapy in esophageal adenocarcinoma Open
Supplementary Figures S1 to S14 Supplementary Figure 1. Multidimensional analysis of baseline EAC tumor and blood samples Supplementary Figure 2. Baseline higher immune gene signatures and reduced resistance to stress are associated with r…
View article: Supplementary Tables from Pre-existing immunity drives the response to neoadjuvant chemotherapy in esophageal adenocarcinoma
Supplementary Tables from Pre-existing immunity drives the response to neoadjuvant chemotherapy in esophageal adenocarcinoma Open
Supplementary Table 1. Clinical characteristics of the EAC patients from the prospective cohort (protocol ESO-CA001) Supplementary Table 2. Clinical characteristics of the EAC patients from the additional retrospective cohort selected for …
View article: Data from Pre-existing immunity drives the response to neoadjuvant chemotherapy in esophageal adenocarcinoma
Data from Pre-existing immunity drives the response to neoadjuvant chemotherapy in esophageal adenocarcinoma Open
Current treatment for patients with locally advanced esophageal adenocarcinoma (EAC) is neoadjuvant chemotherapy (nCT), alone or combined with radiotherapy, before surgery. However, fewer than 30% of treated patients show a pathological co…
View article: Supplementary Figures from Pre-existing immunity drives the response to neoadjuvant chemotherapy in esophageal adenocarcinoma
Supplementary Figures from Pre-existing immunity drives the response to neoadjuvant chemotherapy in esophageal adenocarcinoma Open
Supplementary Figures S1 to S14 Supplementary Figure 1. Multidimensional analysis of baseline EAC tumor and blood samples Supplementary Figure 2. Baseline higher immune gene signatures and reduced resistance to stress are associated with r…
View article: Supplementary Materials and methods from Pre-existing immunity drives the response to neoadjuvant chemotherapy in esophageal adenocarcinoma
Supplementary Materials and methods from Pre-existing immunity drives the response to neoadjuvant chemotherapy in esophageal adenocarcinoma Open
Supplementary Materials and methods
View article: 630. ENDOSCOPIC MANAGEMENT OF DELAYED-GASTRIC-EMPTYING AFTER ESOPHAGECTOMY IN A TERTIARY REFERRAL CENTER: COMPARISON BETWEEN DIFFERENT ENDOSCOPIC PROCEDURES
630. ENDOSCOPIC MANAGEMENT OF DELAYED-GASTRIC-EMPTYING AFTER ESOPHAGECTOMY IN A TERTIARY REFERRAL CENTER: COMPARISON BETWEEN DIFFERENT ENDOSCOPIC PROCEDURES Open
Background Delayed Gastric Emptying (DGE) after Esophagectomy with a gastric conduit is a complication that occurs in 15-39% of patients. It is associated with short and long-term complications and with a poor quality of life. Intra-Pylori…
View article: 490. THE IMPACT OF ONE-LUNG VENTILATION ON POSTOPERATIVE COMPLICATIONS AFTER IVOR LEWIS ESOPHAGECTOMY
490. THE IMPACT OF ONE-LUNG VENTILATION ON POSTOPERATIVE COMPLICATIONS AFTER IVOR LEWIS ESOPHAGECTOMY Open
Background One of the most common issue after Ivor Lewis esophagectomy are pulmonary complications, affecting up to 27% of patients, leading to longer hospital stay and higher healthcare costs. Traditionally, one-lung ventilation (OLV) wit…
View article: 561. COMMONALITY AND VARIATION IN PERIOPERATIVE ESOPHAGEAL CANCER MANAGEMENT IN HIGH VOLUME EUROPEAN CENTERS
561. COMMONALITY AND VARIATION IN PERIOPERATIVE ESOPHAGEAL CANCER MANAGEMENT IN HIGH VOLUME EUROPEAN CENTERS Open
Background Esophageal cancer is a leading cause of cancer related death worldwide. For patients with locally advanced, non-metastatic, esophageal cancer (EC), surgical resection remains an essential pillar. The multitude of surgical option…