Rose Anne Kenny
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View article: How Frequently do Older People in Ireland attend the Emergency Department and what Factors influence ED Attendance? A Population-Based Analysis
How Frequently do Older People in Ireland attend the Emergency Department and what Factors influence ED Attendance? A Population-Based Analysis Open
Background Older people in Ireland are increasingly presenting to Emergency Departments (ED) for unscheduled care. The aim of this study was to examine the frequency of ED presentation over 12 months in a large sample of older people from …
View article: Estimating the Incidence of Stroke where Older People do not present to Hospital using a Large population-Representative Dataset
Estimating the Incidence of Stroke where Older People do not present to Hospital using a Large population-Representative Dataset Open
Background Recognition and investigation of stroke is important in determining aetiology and treating underlying risk factors to prevent reoccurrence. We propose the theory that there is a significant minority of older people with stroke t…
View article: Incidence of Falls Requiring Medical Attention Among Older Adults in Ireland: Findings from Wave 6 of TILDA
Incidence of Falls Requiring Medical Attention Among Older Adults in Ireland: Findings from Wave 6 of TILDA Open
Background Falls represent the most frequent reason older people are admitted to hospital, and significantly increase the likelihood of functional decline, healthcare utilisation and early mortality. Specialist pathways can prevent falls b…
View article: The association between STOPPFall medication use and orthostatic hypotension in community-dwelling older people
The association between STOPPFall medication use and orthostatic hypotension in community-dwelling older people Open
Introduction Fall-risk-increasing drugs (FRIDs), identified by the Screening Tool of Older Persons Prescriptions in older adults with high fall risk (STOPPFall), may increase fall risk by causing orthostatic hypotension (OH). This study in…
View article: How prevalent are modifiable dementia risk factors in Ireland? A 12-year observational study in community-dwelling older adults
How prevalent are modifiable dementia risk factors in Ireland? A 12-year observational study in community-dwelling older adults Open
Objectives Dementia is potentially preventable and deferrable yet remains a major cause of disability, dependency and mortality worldwide. The 2024 Lancet Commission on dementia identified 14 modifiable dementia risk factors and estimated …
View article: Control, Fludrocortisone or Midodrine for the treatment of Orthostatic Hypotension (CONFORM-OH): results from an internal pilot randomised controlled trial
Control, Fludrocortisone or Midodrine for the treatment of Orthostatic Hypotension (CONFORM-OH): results from an internal pilot randomised controlled trial Open
Background Orthostatic hypotension (OH) is a common debilitating condition characterised by a significant drop in blood pressure (BP) on standing upright. Adults with OH are typically offered non-pharmacologic therapies, either alone or in…
View article: Physiological health Age (PhysAge): a novel multi-system molecular timepiece predicts health and mortality in older adults
Physiological health Age (PhysAge): a novel multi-system molecular timepiece predicts health and mortality in older adults Open
The complexity of epigenetic changes that accompany aging has been distilled into a number of molecular timepieces—termed epigenetic clocks—that characterize the pace of biological aging to differing degrees. Here, we develop and validate …
View article: Prospective associations between diabetes and depressive symptoms across European regions: a secondary analysis of ELSA, TILDA, and SHARE datasets
Prospective associations between diabetes and depressive symptoms across European regions: a secondary analysis of ELSA, TILDA, and SHARE datasets Open
This article investigates predictive associations between diabetes and depressive symptoms across Ireland, the United Kingdom, and four European regions. The data were obtained by merging datasets from three large prospective cohort studie…
View article: Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes
Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes Open
Introduction There is a critical link between vascular disease and the progression to dementia. The hippocampus has been implicated in memory and cognitive decline. In this study, we investigate the independent and moderating effects of in…
View article: The hope and the hype of artificial intelligence for syncope management
The hope and the hype of artificial intelligence for syncope management Open
Aims Syncope remains a diagnostic challenge despite advancements in testing and treatment. Cardiac syncope is an independent predictor of mortality and can be difficult to distinguish from other causes of transient loss of consciousness (T…
View article: Control, Fludrocortisone or Midodrine for the treatment of Orthostatic Hypotension (CONFORM-OH): Results from an internal pilot randomised controlled trial
Control, Fludrocortisone or Midodrine for the treatment of Orthostatic Hypotension (CONFORM-OH): Results from an internal pilot randomised controlled trial Open
Background Orthostatic hypotension (OH) is a common debilitating condition characterised by a significant drop in blood pressure (BP) on standing upright. Adults with OH are typically offered non-pharmacologic therapies, either alone or in…
View article: Modelling the impact of changes to prescription medicine cost-sharing schemes among middle aged and older adults
Modelling the impact of changes to prescription medicine cost-sharing schemes among middle aged and older adults Open
Co-payment changes led to average savings of €62 for GMS-eligible participants and €174 for DPS-eligible participants. Although absolute savings were smaller for GMS participants, as the scheme is primarily for low-income populations and t…
View article: Tooth Loss and 12‐Year Mortality Risk in 8494 Older Adults From Ireland
Tooth Loss and 12‐Year Mortality Risk in 8494 Older Adults From Ireland Open
Objectives To investigate whether tooth loss is associated with all‐cause and cause‐specific mortality in older Irish adults. Methods A total of 8494 participants from The Irish Longitudinal Study on Ageing (TILDA) were included. Survey da…
View article: The association between STOPPFall medication use and falls and fractures in community-dwelling older people
The association between STOPPFall medication use and falls and fractures in community-dwelling older people Open
Introduction Falls and fractures are common among older people. The Screening Tool of Older Persons Prescriptions in older adults with high fall risk (STOPPFall) provides a comprehensive list of fall-risk-increasing drugs (FRIDs). This stu…
View article: Changes in depressive symptoms during the COVID-19 pandemic differ by personality type: Findings from The Irish Longitudinal Study on Ageing
Changes in depressive symptoms during the COVID-19 pandemic differ by personality type: Findings from The Irish Longitudinal Study on Ageing Open
Background This study examined the Big 5 personality traits as potential sources of heterogeneity in changes in depressive symptoms while accounting for pre-pandemic trends in depressive symptoms. Methods Data from 5 waves of The Irish Lon…
View article: Epigenetic Clocks Relate to 4 Age-related Health Outcomes Similarly Across 3 Countries
Epigenetic Clocks Relate to 4 Age-related Health Outcomes Similarly Across 3 Countries Open
Background Measures of epigenetic age have been linked to life circumstances and health outcomes in older populations. The similarity of these relationships across multiple populations in well-harmonized data has not been addressed. We exa…
View article: Can ambulatory blood pressure biomarkers predict future falls amongst older people?
Can ambulatory blood pressure biomarkers predict future falls amongst older people? Open
Background While ambulatory blood pressure monitoring (ABPM) biomarkers can predict cardiovascular and cerebrovascular outcomes, little work to date has examined their link with falls. The objective of this study was to examine association…
View article: Connecting the dots: microstructural properties of white matter hyperintensities predict longitudinal cognitive changes in ageing
Connecting the dots: microstructural properties of white matter hyperintensities predict longitudinal cognitive changes in ageing Open
This study investigates the relationship between white matter hyperintensities (WMHs) and longitudinal cognitive decline in older adults. Using data from The Irish Longitudinal Study on Ageing (TILDA), we examined WMH characteristics, incl…
View article: Modelling the impact of changes to prescription medicine cost-sharing schemes among middle aged and older adults
Modelling the impact of changes to prescription medicine cost-sharing schemes among middle aged and older adults Open
Objective To assess impacts of government changes to prescription medicine co-payments on individuals’ out-of-pocket prescription medicine expenditure. Methods Data from The Irish Longitudinal Study on Ageing were used. Participants were c…
View article: Assessing Metabolic Ageing via <scp>DNA</scp> Methylation Surrogate Markers: A Multicohort Study in Britain, Ireland and the <scp>USA</scp>
Assessing Metabolic Ageing via <span>DNA</span> Methylation Surrogate Markers: A Multicohort Study in Britain, Ireland and the <span>USA</span> Open
Metabolomics and epigenomics have been used to develop ‘ageing clocks’ that assess biological age and identify ‘accelerated ageing’. While metabolites are subject to short‐term variation, DNA methylation (DNAm) may capture longer‐term meta…
View article: The Association of Regular Dog Walking With Mobility, Falls, and Fear of Falling in Later Life
The Association of Regular Dog Walking With Mobility, Falls, and Fear of Falling in Later Life Open
Background It has been suggested that dog walking may protect against falls and mobility problems in later life, but little work to date has examined this. The aim of this study was to assess if regular dog walking was associated with redu…
View article: Syncope: Advances in Diagnosis and Treatment 2024
Syncope: Advances in Diagnosis and Treatment 2024 Open
Aim In light of many recent advances in the field of vasovagal syncope, a selective review has been undertaken of these developments. Methods Recent publications on the following topics were reviewed; understanding of vasovagal syncope pat…
View article: Examining the relationships between in-person and remote religious attendance and loneliness, quality of life, stress, and anxiety among older adults during COVID-19 in Ireland
Examining the relationships between in-person and remote religious attendance and loneliness, quality of life, stress, and anxiety among older adults during COVID-19 in Ireland Open
Background Religious attendance has been shown to have a positive effect on psychological health among the older people (Moon & Kim, 2013). Due to COVID-19 lockdown restrictions and precautionary health advice, many older adults struggled …
View article: Regional changes in cerebral perfusion with age when accounting for changes in gray‐matter volume
Regional changes in cerebral perfusion with age when accounting for changes in gray‐matter volume Open
Purpose One possible contributing factor for cerebral blood flow (CBF) decline in normal aging is the increase in partial volume effects due to brain atrophy, as cortical thinning can exacerbate the contamination of gray‐matter (GM) voxels…