A. Runz
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View article: A dynamic anthropomorphic phantom for end‐to‐end testing in image‐ and surface‐guided adaptive radiotherapy
A dynamic anthropomorphic phantom for end‐to‐end testing in image‐ and surface‐guided adaptive radiotherapy Open
Background Respiratory and digestive motion can compromise the accuracy of radiotherapy (RT), affecting tumor targeting and healthy tissue sparing. Current phantoms often fail to replicate complex organ movements and lack compatibility wit…
View article: Carbon ion mono-energetic and spread-out Bragg peak measurements using nanocomposite Fricke gel dosimeters with LET-independent response
Carbon ion mono-energetic and spread-out Bragg peak measurements using nanocomposite Fricke gel dosimeters with LET-independent response Open
This study investigates the LET-dependence of dose measurements performed with a nanocomposite Fricke gel (NC-FG) upon irradiation with carbon ion beams to address the problem of quenching of gel dosimeters in high-LET particle therapy. Th…
View article: Dosimetric study for breathing‐induced motion effects in an abdominal pancreas phantom for carbon ion mini‐beam radiotherapy
Dosimetric study for breathing‐induced motion effects in an abdominal pancreas phantom for carbon ion mini‐beam radiotherapy Open
Background Particle mini‐beam therapy exhibits promise in sparing healthy tissue through spatial fractionation, particularly notable for heavy ions, further enhancing the already favorable differential biological effectiveness at both targ…
View article: A phantom to simulate organ motion and its effect on dose distribution in carbon ion therapy for pancreatic cancer
A phantom to simulate organ motion and its effect on dose distribution in carbon ion therapy for pancreatic cancer Open
Objective . Carbon ion radiotherapy is a promising radiation technique for malignancies like pancreatic cancer. However, organs’ motion imposes challenges for achieving homogeneous dose delivery. In this study, an anthropomorphic P ancreas…
View article: Proton beam dosimetry in the presence of magnetic fields using Farmer‐type ionization chambers of different radii
Proton beam dosimetry in the presence of magnetic fields using Farmer‐type ionization chambers of different radii Open
Background Magnetic resonance‐guided proton therapy is promising, as it combines high‐contrast imaging of soft tissue with highly conformal dose delivery. However, proton dosimetry in magnetic fields using ionization chambers is challengin…
View article: RSC: Gel dosimetry as a tool for clinical implementation of image-guided radiotherapy
RSC: Gel dosimetry as a tool for clinical implementation of image-guided radiotherapy Open
The implementation of new image-guided radiotherapy (IGRT) treatment techniques requires the development of new quality assurance (QA) methods including geometric and dosimetric validation of the applied dose in 3D. Polymer gels (PG) provi…
View article: Experimental comparison of photon versus particle computed tomography to predict tissue relative stopping powers
Experimental comparison of photon versus particle computed tomography to predict tissue relative stopping powers Open
Purpose : Measurements comparing relative stopping power (RSP) accuracy of state‐of‐the‐art systems representing single‐energy and dual‐energy computed tomography (SECT/DECT) with proton CT (pCT) and helium CT (HeCT) in biological tissue s…
View article: The accuracy of helium ion CT based particle therapy range prediction: an experimental study comparing different particle and x-ray CT modalities
The accuracy of helium ion CT based particle therapy range prediction: an experimental study comparing different particle and x-ray CT modalities Open
This work provides a quantitative assessment of helium ion CT (HeCT) for particle therapy treatment planning. For the first time, HeCT based range prediction accuracy in a heterogeneous tissue phantom is presented and compared to single-en…
View article: Technical Note: ADAM PETer – An anthropomorphic, deformable and multimodality pelvis phantom with positron emission tomography extension for radiotherapy
Technical Note: ADAM PETer – An anthropomorphic, deformable and multimodality pelvis phantom with positron emission tomography extension for radiotherapy Open
Objective To develop an a nthropomorphic, d eformable a nd m ultimodal pelvis phantom with p ositron e mission t omography e xtension for r adiotherapy (ADAM PETer). Methods The design of ADAM PETer was based on our previous pelvis phantom…
View article: <i>The biomedical sensor Cell-Fit-HD<sup>4D</sup></i>, reveals individual tumor cell fate in response to microscopic ion deposition
<i>The biomedical sensor Cell-Fit-HD<sup>4D</sup></i>, reveals individual tumor cell fate in response to microscopic ion deposition Open
Here we present the biomedical sensor cell - f luorescent i on t rack h ybrid d etector 4D ( Cell-Fit-HD 4D ) to reveal individual tumor cell fate in response to microscopic ion deposition in ion beam therapy. The sensor enables long-term …
View article: End-to-end test of an online adaptive treatment procedure in MR-guided radiotherapy using a phantom with anthropomorphic structures
End-to-end test of an online adaptive treatment procedure in MR-guided radiotherapy using a phantom with anthropomorphic structures Open
Online adaptive treatment procedures in magnetic resonance (MR)-guided radiotherapy (MRgRT) allow compensating for inter-fractional anatomical variations in the patient. Clinical implementation of these procedures, however, requires specif…
View article: Measurement of isocenter alignment accuracy and image distortion of an 0.35 T MR-Linac system
Measurement of isocenter alignment accuracy and image distortion of an 0.35 T MR-Linac system Open
For hybrid devices combining magnetic resonance (MR) imaging and a linac for radiation treatment, the isocenter accuracy as well as image distortions have to be checked. This study presents a new phantom to investigate MR-Linacs in a singl…
View article: Polymer gel-based measurements of the isocenter accuracy in an MR-LINAC
Polymer gel-based measurements of the isocenter accuracy in an MR-LINAC Open
As magnetic resonance-guided radiotherapy (MRgRT) is becoming increasingly important in clinical applications, the development of new quality assurance (QA) methods is needed. One important aspect is the alignment of the radiation and imag…
View article: Compatibility of 3D printing materials and printing techniques with PAGAT gel dosimetry
Compatibility of 3D printing materials and printing techniques with PAGAT gel dosimetry Open
Polymer gel (PG) dosimetry enables three dimensional (3D) measurement of complex dose distributions. However, PGs are strongly reactive with oxygen and other contaminations, limiting their applicability by the need to use specific containe…
View article: The ADAM-pelvis phantom—an anthropomorphic, deformable and multimodal phantom for MRgRT
The ADAM-pelvis phantom—an anthropomorphic, deformable and multimodal phantom for MRgRT Open
Applicability and accuracy of the rapidly developing tools and workflows for image-guided radiotherapy need to be validated under realistic treatment-like conditions. We present the construction of the ADAM-pelvis phantom, an anthropomorph…
View article: Feasibility of polymer gel-based measurements of radiation isocenter accuracy in magnetic fields
Feasibility of polymer gel-based measurements of radiation isocenter accuracy in magnetic fields Open
For conventional irradiation devices, the radiation isocenter accuracy is determined by star shot measurements on films. In magnetic resonance (MR)-guided radiotherapy devices, the results of this test may be altered by the magnetic field …