Anthony C. Ruocco
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View article: Basal Forebrain Volume and Concurrent Hallucinations and Mild Cognitive Impairment in Parkinson's Disease
Basal Forebrain Volume and Concurrent Hallucinations and Mild Cognitive Impairment in Parkinson's Disease Open
Background Visual hallucinations (VH) and mild cognitive impairment (MCI) often co‐occur in Parkinson's Disease (PD). Each symptom in isolation is associated with cholinergic basal forebrain (BF) atrophy. However, it is unclear whether BF …
View article: Experiences and barriers to alcohol use disorder treatment among adults with and without self‐reported executive functioning challenges: A mixed‐methods study
Experiences and barriers to alcohol use disorder treatment among adults with and without self‐reported executive functioning challenges: A mixed‐methods study Open
Background Executive functioning (EF)—the ability to plan, organize, and complete goal‐directed tasks—plays a critical role in the onset and course of alcohol use disorder (AUD). Individuals with AUD often report challenges in EF domains, …
View article: Profiles of impulsivity and alcohol use: Unveiling personality, cognitive traits, and <scp>DSM</scp> diagnoses
Profiles of impulsivity and alcohol use: Unveiling personality, cognitive traits, and <span>DSM</span> diagnoses Open
Background Impulsivity is closely associated with alcohol use, but limited research has explored distinct latent profiles encompassing impulsivity traits and alcohol use disorder symptoms. Methods This study used latent profile analysis (L…
View article: Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research program
Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research program Open
Substance use disorders (SUDs), including Alcohol Use Disorder, are pressing global public health problems. Executive functions (EFs) are prominently featured in mechanistic models of addiction. However, significant gaps remain in our unde…
View article: Hippocampal damage disrupts the latent decision-making processes underlying approach-avoidance conflict processing in humans
Hippocampal damage disrupts the latent decision-making processes underlying approach-avoidance conflict processing in humans Open
Rodent and human data implicate the hippocampus in the arbitration of approach-avoidance conflict (AAC), which arises when an organism is confronted with a stimulus associated simultaneously with reward and punishment. Yet, the precise con…
View article: Basal forebrain volume and concurrent hallucinations and mild cognitive impairment in Parkinson's disease
Basal forebrain volume and concurrent hallucinations and mild cognitive impairment in Parkinson's disease Open
Background Visual hallucinations (VH) and mild cognitive impairment (MCI) often co-occur in Parkinson's Disease (PD). Each symptom in isolation is associated with cholinergic basal forebrain (BF) atrophy. However, it is unclear whether BF …
View article: Cognitive Dysfunction in the Addictions (CDiA): A Neuron to Neighbourhood Collaborative Research Program on Executive Dysfunction and Functional Outcomes in Outpatients Seeking Treatment for Addiction
Cognitive Dysfunction in the Addictions (CDiA): A Neuron to Neighbourhood Collaborative Research Program on Executive Dysfunction and Functional Outcomes in Outpatients Seeking Treatment for Addiction Open
Background: Substance use disorders (SUDs) are pressing global public health problems. Executive functions (EFs) are prominently featured in mechanistic models of addiction. However, there remain significant gaps in our understanding of EF…
View article: Transcutaneous auricular vagus nerve stimulation to acutely reduce emotional vulnerability and improve emotional regulation in borderline personality disorder (tVNS-BPD): study protocol for a randomized, single-blind, sham-controlled trial
Transcutaneous auricular vagus nerve stimulation to acutely reduce emotional vulnerability and improve emotional regulation in borderline personality disorder (tVNS-BPD): study protocol for a randomized, single-blind, sham-controlled trial Open
Background Borderline personality disorder (BPD) is considered a disorder of emotion regulation resulting from the expression of a biologically determined emotional vulnerability (that is, heightened sensitivity to emotion, increased emoti…
View article: DSM-5 suicidal behavior disorder: a systematic review of research on clinical utility, diagnostic boundaries, measures, pathophysiology and interventions
DSM-5 suicidal behavior disorder: a systematic review of research on clinical utility, diagnostic boundaries, measures, pathophysiology and interventions Open
Background It has been a decade since Suicidal Behavior Disorder (SBD) was introduced in Section III of the DSM-5 under “Conditions for Further Study”. SBD is chiefly characterized by a self-initiated sequence of behaviors believed at the …
View article: Pretreatment cognitive performance is associated with differential self-harm outcomes in 6 <i>v</i>. 12-months of dialectical behavior therapy for borderline personality disorder
Pretreatment cognitive performance is associated with differential self-harm outcomes in 6 <i>v</i>. 12-months of dialectical behavior therapy for borderline personality disorder Open
Background Recent findings suggest that brief dialectical behavior therapy (DBT) for borderline personality disorder is effective for reducing self-harm, but it remains unknown which patients are likely to improve in brief v. 12 months of …
View article: 65 Is Basal Forebrain Volume Loss Associated with Visual Hallucinations, Mild Cognitive Impairment, or Concomitant Symptomology in Advanced Parkinson’s Disease?
65 Is Basal Forebrain Volume Loss Associated with Visual Hallucinations, Mild Cognitive Impairment, or Concomitant Symptomology in Advanced Parkinson’s Disease? Open
Objective: Among individuals with Parkinson’s Disease (PD), visual hallucinations (VH) and mild cognitive impairment (MCI) are highly prevalent and often co-occur. Atrophy in similar brain regions [e.g. cholinergic basal forebrain (BF) nuc…
View article: 50 Neuropsychological Functioning in Depression, Borderline Personality Disorder, and Suicidality
50 Neuropsychological Functioning in Depression, Borderline Personality Disorder, and Suicidality Open
Objective: Depression and borderline personality disorder (BPD) are frequently comorbid psychiatric disorders that reliably share deficits in executive functioning (EF). In addition to EF, meta-analytic evidence indicates that processing s…
View article: GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential
GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential Open
Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and economic costs, and leads to approximately 3 million global deaths yearly. Alcohol use…
View article: Executive functions and behavioral economic demand for cannabis among young adults: Indirect associations with cannabis consumption and cannabis use disorder.
Executive functions and behavioral economic demand for cannabis among young adults: Indirect associations with cannabis consumption and cannabis use disorder. Open
Behavioral economic demand for cannabis is robustly associated with cannabis consumption and cannabis use disorder (CUD). However, few studies have examined the processes underlying individual differences in the relative valuation of canna…
View article: Transcutaneous vagus nerve stimulation (tVNS) to acutely reduce emotional vulnerability and improve emotional regulation in borderline personality disorder (tVNS-BPD): study protocol for a randomized, single-blind, sham-controlled trial
Transcutaneous vagus nerve stimulation (tVNS) to acutely reduce emotional vulnerability and improve emotional regulation in borderline personality disorder (tVNS-BPD): study protocol for a randomized, single-blind, sham-controlled trial Open
Background: Borderline personality disorder (BPD) is considered a disorder of emotion regulation resulting from the expression of a biologically determined emotional vulnerability (that is, heightened sensitivity to emotion, increased emot…
View article: Suicide risk detection using artificial intelligence: the promise of creating a benchmark dataset for research on the detection of suicide risk
Suicide risk detection using artificial intelligence: the promise of creating a benchmark dataset for research on the detection of suicide risk Open
Suicide is a leading cause of death that demands cross-disciplinary research efforts to develop and deploy suicide risk screening tools. Such tools, partly informed by influential suicide theories, can help identify individuals at the grea…
View article: Impulsivity, suicidal thoughts, psychological distress, and religiosity in adolescents and young adults
Impulsivity, suicidal thoughts, psychological distress, and religiosity in adolescents and young adults Open
Background Impulsivity is associated with suicidal acts and ideation, whereas higher religious commitment has been identified as a potential protective factor linked to lower suicidal ideation. Objectives We examined the extent to which hi…
View article: An exploratory study of functional brain activation underlying response inhibition in major depressive disorder and borderline personality disorder
An exploratory study of functional brain activation underlying response inhibition in major depressive disorder and borderline personality disorder Open
Cognitive control is associated with impulsive and harmful behaviours, such as substance abuse and suicidal behaviours, as well as major depressive disorder (MDD) and borderline personality disorder (BPD). The association between MDD and B…
View article: Visual content underlying perception and memory for facial expression: Associations with personality disorder traits
Visual content underlying perception and memory for facial expression: Associations with personality disorder traits Open
Prior work has suggested that individuals with personality disorders (PD) have difficulties recognizing facial emotional expressions. However, most of this work has relied on small groups of clinical participants and targeted small sets of…
View article: Acute effect of physical exercise on negative affect in borderline personality disorder: A pilot study
Acute effect of physical exercise on negative affect in borderline personality disorder: A pilot study Open
Background Physical exercise is an evidence-based treatment to reduce symptoms and negative affect in several psychiatric disorders, including depressive, anxiety, and psychotic disorders. However, the effect of physical exercise on negati…
View article: Daily associations between cannabis use and alcohol use in young adults: the moderating role of self-report and behavioral measures of impulsivity
Daily associations between cannabis use and alcohol use in young adults: the moderating role of self-report and behavioral measures of impulsivity Open
Although impulsivity has been implicated in cannabis and alcohol use, its role in alcohol and cannabis co-use behavior use requires further study. We examined the moderating role of self-report and behavioral measures of impulsivity in the…
View article: Acute Effect of Physical Exercise on Negative Affect in Borderline Personality Disorder: A Pilot Study
Acute Effect of Physical Exercise on Negative Affect in Borderline Personality Disorder: A Pilot Study Open
Physical exercise is an evidence-based treatment to reduce symptoms and negative affect in several psychiatric disorders, including depressive, anxiety, and psychotic disorders. However, the effect of physical exercise on negative affect i…
View article: Attentional salience and the neural substrates of response inhibition in borderline personality disorder
Attentional salience and the neural substrates of response inhibition in borderline personality disorder Open
Background Impulsivity is a central symptom of borderline personality disorder (BPD) and its neural basis may be instantiated in a frontoparietal network involved in response inhibition. However, research has yet to determine whether neura…
View article: Facial Emotion Perception in Borderline Personality Disorder: Differential Neural Activation to Ambiguous and Threatening Expressions and Links to Impairments in Self and Interpersonal Functioning
Facial Emotion Perception in Borderline Personality Disorder: Differential Neural Activation to Ambiguous and Threatening Expressions and Links to Impairments in Self and Interpersonal Functioning Open
These findings suggest a heightened amygdala-hippocampal response to neutral faces and moderate-intensity fearful expressions in BPD, while self and interpersonal impairments are associated with task-based activations in regions implicated…
View article: Executive functioning in adults with borderline personality disorder and first-degree biological relatives
Executive functioning in adults with borderline personality disorder and first-degree biological relatives Open
Behavioural dysregulation is a heritable core symptom domain in borderline personality disorder (BPD) that is likely influenced by the integrity of executive functions (EFs). However, the extent to which familial risk for BPD confers decre…
View article: Reduced Levels of Vasopressin and Reduced Behavioral Modulation of Oxytocin in Psychotic Disorders
Reduced Levels of Vasopressin and Reduced Behavioral Modulation of Oxytocin in Psychotic Disorders Open
Oxytocin (OT) and arginine vasopressin (AVP) exert robust influence on social affiliation and specific cognitive processes in healthy individuals. Abnormalities in these neuroendocrine systems have been observed in psychotic disorders, but…
View article: Which Emotion Regulation Strategies are Most Associated with Trait Emotion Dysregulation? A Transdiagnostic Examination
Which Emotion Regulation Strategies are Most Associated with Trait Emotion Dysregulation? A Transdiagnostic Examination Open
Although definitions of emotion dysregulation infer difficulties in selecting and implementing emotion regulation (ER) strategies, surprisingly few studies have examined the relationship between trait emotion dysregulation and a wide range…