Naveed Sattar
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View article: Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes
Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes Open
Among patients with type 2 diabetes and atherosclerotic cardiovascular disease, tirzepatide was noninferior to dulaglutide with respect to a composite of death from cardiovascular causes, myocardial infarction, or stroke. (Funded by Eli Li…
View article: Progressive increases in adiposity and ectopic fat surrogates across glycaemic states highlight weight reduction as a key target for type 2 diabetes prevention, especially in younger people
Progressive increases in adiposity and ectopic fat surrogates across glycaemic states highlight weight reduction as a key target for type 2 diabetes prevention, especially in younger people Open
Aims To determine whether there are progressive changes in weight and ectopic fat surrogates in individuals comparing normoglycaemia, prediabetes and undiagnosed type 2 diabetes, and whether these increments differ by age. Materials and Me…
View article: Tirzepatide and change in uric acid and its association with weight reduction: post hoc analyses of the SURMOUNT-1 randomised placebo-controlled trial
Tirzepatide and change in uric acid and its association with weight reduction: post hoc analyses of the SURMOUNT-1 randomised placebo-controlled trial Open
In this post hoc analysis, in participants with obesity or overweight, tirzepatide was associated with meaningfully reduced SUA levels, regardless of participants' baseline BMI or SUA levels, and appeared to be so primarily via weight redu…
View article: Ethnic differences in HDL quantity, quality, and potential associations with coronary heart disease risk
Ethnic differences in HDL quantity, quality, and potential associations with coronary heart disease risk Open
Lower HDL-c concentrations in South Asian and Black vs White participants appear largely driven by differential physical activity and/or adiposity measures. In South Asian individuals, HDL quantity and quality measures may be more strongly…
View article: Effectiveness and safety of combining SGLT2 inhibitors and GLP-1 receptor agonists in individuals with type 2 diabetes: a systematic review and meta-analysis of cohort studies
Effectiveness and safety of combining SGLT2 inhibitors and GLP-1 receptor agonists in individuals with type 2 diabetes: a systematic review and meta-analysis of cohort studies Open
Aims/hypothesis Sodium–glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) reduce cardiorenal risk in type 2 diabetes. However, the effect of combining these drugs remains uncertain. This sy…
View article: Waist, waist-height-ratio vs body mass index and the risks of multiple diseases: a cohort study with replication
Waist, waist-height-ratio vs body mass index and the risks of multiple diseases: a cohort study with replication Open
Importance Body mass index (BMI) is widely used to assess obesity-related health risks, but waist circumference (WC) and waist-to-height ratio (WHtR) are thought to better capture central adiposity and associated disease risk. Objective To…
View article: Factors associated with elevated high-sensitivity C-reactive protein levels in individuals with atherosclerotic cardiovascular disease in the USA and the UK
Factors associated with elevated high-sensitivity C-reactive protein levels in individuals with atherosclerotic cardiovascular disease in the USA and the UK Open
Aims Novel therapies are under evaluation for upstream inhibition of inflammatory pathways in atherosclerotic cardiovascular disease (ASCVD). Elevated high-sensitivity C-reactive protein (hsCRP) is a downstream marker of these pathways but…
View article: Differences in tissue-specific insulin resistance between South Asian and Nordic women with prediabetes after gestational diabetes
Differences in tissue-specific insulin resistance between South Asian and Nordic women with prediabetes after gestational diabetes Open
Aims/hypothesis The aim of this work was to investigate tissue-specific insulin resistance in South Asian and Nordic women with previous gestational diabetes mellitus (pGDM) and to evaluate potential ethnic differences contributing to type…
View article: XBP1 expression in pancreatic islet cells is associated with poor glycaemic control especially in young non-obese onset diabetes across ancestries
XBP1 expression in pancreatic islet cells is associated with poor glycaemic control especially in young non-obese onset diabetes across ancestries Open
Background Individuals of South and East Asian ancestry have a higher risk of type 2 diabetes, often driven by insulin deficiency due to impaired beta-cell function. The transcription factor XBP1 supports beta-cell survival by reducing cel…
View article: Precision prescribing of SGLT2-inhibitors in people with type 2 diabetes for primary prevention of heart failure: model development and validation study
Precision prescribing of SGLT2-inhibitors in people with type 2 diabetes for primary prevention of heart failure: model development and validation study Open
Objectives To develop and validate a model to predict individual-level benefits of SGLT2-inhibitors for heart failure prevention in people with type 2 diabetes who do not have atherosclerotic cardiovascular disease (ASCVD), heart failure (…
View article: Ectopic Fat distribution and adverse muscle composition in South Asians: Findings from the UK biobank
Ectopic Fat distribution and adverse muscle composition in South Asians: Findings from the UK biobank Open
Background: South Asians (SA) have higher risk of cardiometabolic disease compared to other ethnicities. However, detailed analyses of body compositional profile (BCP) in large cohorts with inclusion of ectopic fat depots and muscle compos…
View article: Nonlinear Associations and Isocaloric Substitution of Macronutrients With Incident Type 2 Diabetes
Nonlinear Associations and Isocaloric Substitution of Macronutrients With Incident Type 2 Diabetes Open
In this study, excess free sugar, starch, and animal protein were associated with higher type 2 diabetes risk. People at risk of diabetes who have a high intake of these macronutrients should consider substitution with non-free sugar and p…
View article: Trends in mortality and hospitalisations for cardiovascular, kidney and liver disease in people with type 2 diabetes in England, 2009–2019
Trends in mortality and hospitalisations for cardiovascular, kidney and liver disease in people with type 2 diabetes in England, 2009–2019 Open
Aims To assess longitudinal trends in total and cause‐specific mortality rates and in hospitalisation rates for diabetes complications among people with type 2 diabetes in England between 2009 and 2019; and to assess how trends differ by p…
View article: Assessing the representativeness of trials of Sodium-glucose Cotransporter- 2 inhibitors in type 2 diabetes
Assessing the representativeness of trials of Sodium-glucose Cotransporter- 2 inhibitors in type 2 diabetes Open
Background Randomised controlled trials are often criticised for excluding people with multiple long-term conditions. This study used individual participant data for 25 trials of sodium glucose co-transporter-2 inhibitors (SGLT2i) to compa…
View article: Validation of a treatment selection algorithm for optimal choice of SGLT2 and DPP4 inhibitor therapies in people with type 2 diabetes across major UK ethnicity groups
Validation of a treatment selection algorithm for optimal choice of SGLT2 and DPP4 inhibitor therapies in people with type 2 diabetes across major UK ethnicity groups Open
Background Targeting type 2 diabetes treatments based on the routine clinical features of individual patients represents a practical precision medicine approach with potential worldwide applicability. We aimed to evaluate a recently propos…
View article: Forecasting Atherosclerotic Cardiovascular Disease in South Asia Until 2040
Forecasting Atherosclerotic Cardiovascular Disease in South Asia Until 2040 Open
IHD and PAD prevalence rates are projected to increase in South Asia with a disproportionate increase among females.
View article: Weight Reduction With Tirzepatide Varied Meaningfully by Baseline HbA1c Category in Adults With Overweight or Obesity and Type 2 Diabetes in SURMOUNT-2
Weight Reduction With Tirzepatide Varied Meaningfully by Baseline HbA1c Category in Adults With Overweight or Obesity and Type 2 Diabetes in SURMOUNT-2 Open
International audience
View article: Cardiovascular–kidney–metabolic syndrome and mortality in a prospective UK cohort study
Cardiovascular–kidney–metabolic syndrome and mortality in a prospective UK cohort study Open
No abstract available.
View article: Genetic risk for Alzheimer’s disease, and differential trajectories in circulating blood biomarkers in UK Biobank (n=17,817)
Genetic risk for Alzheimer’s disease, and differential trajectories in circulating blood biomarkers in UK Biobank (n=17,817) Open
Understanding pathways from genetic variation to cognitive impairment is critical for dementia prevention, risk stratification and the development of treatments. While genetic risk factors for dementia are known to associate with cross-sec…
View article: From Weight Loss to Multimorbidity Prevention: Framing the Anticipated Contributions of <scp>SURMOUNT</scp>‐<scp>MMO</scp>
From Weight Loss to Multimorbidity Prevention: Framing the Anticipated Contributions of <span>SURMOUNT</span>‐<span>MMO</span> Open
No abstract available.
View article: Body mass index and infection risks in people with and without type 2 diabetes: A cohort study using electronic health records
Body mass index and infection risks in people with and without type 2 diabetes: A cohort study using electronic health records Open
Background Observational studies have found U-shaped associations between body mass index (BMI) and infections. While people with type 2 diabetes (T2D) are generally more likely to live with obesity and be at higher risk of infections, it …
View article: Genetic subtypes of type 2 diabetes are distinguished through the lens of abdominal MRI
Genetic subtypes of type 2 diabetes are distinguished through the lens of abdominal MRI Open
Objective This study seeks to understand type 2 diabetes (T2D) heterogeneity through detailed phenotypic characterization of various T2D genetic subtypes using advanced magnetic resonance imaging (MRI) techniques. Study design and method M…
View article: Tirzepatide and cardiometabolic parameters in obesity: Summary of current evidence
Tirzepatide and cardiometabolic parameters in obesity: Summary of current evidence Open
Globally, cardiovascular diseases (CVDs) account for around one‐third of all deaths. Clinical trial evidence suggests that treatment of people with obesity or type 2 diabetes (T2D) and CVD with glucagon‐like peptide‐1 (GLP‐1) receptor agon…