О. Savchuk
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Zn64 aspartate modulates inflammation, tryptophan metabolism, and pancreatic function in diet-induced obesity Open
Obesity-induced metabolic syndrome is characterized by chronic inflammation, hormonal imbalance, and altered neurotransmitter metabolism. Zinc plays a critical role in immune regulation and energy balance; however, the effects of isotopica…
Phytocompounds as sustainable therapeutics for breast cancer treatment: a comprehensive review on isolation and delivery strategies Open
Globally, breast cancer is one of the most widespread malignancies among women, posing a significant Healthcare challenge that necessitates a comprehensive treatment approach. This paper explores the potential of phytochemicals as therapeu…
The content of inflammatory, antiphlogistic and stress biomarkers in the heart after<i> Leiurus macroctenus</i> envenomation Open
Scorpions belonging to the species Leiurus macroctenus are known to be very dangerous, but the effect of their venom on cytokine and stress biomarker levels in the heart is still poorly understood. The aim of this study was to analyse the …
C<sub>60</sub> fullerene improves the rat <i>musculus soleus</i> contractile activity after ischemic stroke-related peptide administration Open
The results of our previous study revealed that ischemic stroke (IS) is accompanied by an increased concentration of plasma peptides, furthermore, circulatory IS-related peptides may trigger the progression of IS-associated complications. …
View article: A Rare Case Report: Facial cellulitis secondary to Methicillin Resistant Staphylococcus Aureus Infection in an 8-month-old infant with Dengue Fever.
A Rare Case Report: Facial cellulitis secondary to Methicillin Resistant Staphylococcus Aureus Infection in an 8-month-old infant with Dengue Fever. Open
Background: Dengue Fever (DF), a mosquito-borne illness caused by the Dengue virus (DenV), is known for its systemic and haemorrhagic manifestations. Secondary bacterial infections, though rare in paediatric patients, can complicate the cl…
Cytokine profile and proteolytic enzyme levels in plasma of patients with chronic cerebral ischemia following COVID-19 Open
Background. The purpose of this study was to determine the cytokine profile, levels of proteolytic enzymes, and the TIMP-1 in the plasma of patients with chronic cerebral ischemia (CCI) following symptomatic COVID-19, considering gender di…
Therapeutic potential of zinc 64Zn aspartate for obesity management: impact on oxidative stress, lipid metabolism, pancreas and liver in high-calorie diet model Open
Zinc is a critical micronutrient that plays multifaceted roles in oxidative stress management, lipid metabolism, pancreatic function, and liver health, which are all closely interconnected with obesity. Maintaining adequate zinc levels is …
Biosafety and Blood Compatibility of Graphene Oxide Particles in In Vitro Experiments Open
Graphene oxide (GO), owing to its extraordinary application prospects in biomedicine, is attracting growing research attention. However, the biosafety and blood compatibility of GO required for its clearance for use in clinical trials rema…
Detection Of Association Between Asthma And Air Pollution in Urban Regions Using Supervised Learning Open
Traffic and power generation are the main sources of urban air pollution. One of the most significant environmental risk factors for asthma is air pollution. Asthma, a chronic respiratory disease characterized by inflammation and narrowing…
View article: The levels of inflammatory, angiogenic, and stress biomarkers in plasma of donors depending on anti-SARS-CoV-2 IgG titers
The levels of inflammatory, angiogenic, and stress biomarkers in plasma of donors depending on anti-SARS-CoV-2 IgG titers Open
Background. Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has led to widespread illness and global health challenges. While the acute phase of the infection has b…
Antioxidant properties of common bean (<i>Phaseolus vulgaris</i>) husk-derived peptides Open
Protein hydrolysates and plant peptide extracts can become next-generation natural, eco-friendly food supplementary with a wide range of bioactive features. From folk medicine, it is known about the aqueous extract of the common bean (Phas…
A Scoping Strategic survey of post-natal mothers on adverse events following immunization from the urbanized areas in the south Tamilnadu Open
Adverse Events Following Immunization (AEFI) are a significant public health concern, particularly in pediatric immunization programs. This study aims to evaluate the occurrence and impact of AEFI among postnatal mothers in urbanized areas…
Peptide pool instability of precancerous lesions in rats with chronic pancreatitis model and/or without type 1 diabetes mellitus Open
The analysis of peptide pools obtained from plasma and PanIN development demonstrated that the peptide pool can serve as an early and complementary indicator of PC emergence.
Comparative Evaluation of the Fluoride Content in Plant-based and Animal-based Milk: An In Vitro Study Open
Increased fluoride ion concentrations at the dental plaque reduce the rate of demineralization, but when ingested in large amounts, it can cause enamel fluorosis. Milk has been utilized as a nutritional supplement and is already a signific…
Functional delivery of xenogeneic p53 via extracellular vesicles induces apoptosis in human cancer cells Open
TP53 (encoding for the p53 tumor suppressor protein) is the most frequently mutated or deleted gene in human cancers, undermining p53's critical role in regulating cell cycle arrest and apoptosis. Here, we present a novel p53 replacement s…
Coagulopathy in the experimental rats elicited by Vipera berus berus or Vipera berus nikolskii envenomation Open
Viper snakebite is considered to be a serious and life-threatening medical problem due to its ability to cause various types of coagulopathies. The current study aimed to investigate the effects of Vipera berus berus and Vipera berus nikol…
Collagenolytic enzymes from Antarctic hydrobionts: a promising biotechnological approach for accelerating purulent-necrotic wound healing Open
The objective of this study was to isolate the fractions of proteolytic enzymes from Antarctic hydrobionts, specifically Sterechinus neumayeri and Odontaster validus, and assess their wound-healing potential on purulent-necrotic wounds in …
Antibacterial Efficacy of Silver Diamine Fluoride and 3M ESPE ClinproTMTooth Crème Against Streptococcus mutans: A Comparative in vitrostudy Open
Background:Remineralizing agents such as Silver Diamine Fluoride (SDF) and 3M ESPETMClinpro Tooth Crème have gained attention for their potential antimicrobial and enamel-strengthening properties. While fluoride-based therapies are widely …
Proteostasis collapse in rat’s lung tissue as one of the effects of European adder (<i>Vipera berus subsp. berus</i> and <i>Vipera berus subsp. nikolskii</i>) envenomation Open
Snakebites and their consequences are a growing concern around the globe. The mixture of enzymes, present in snake venom is a great challenge for a snakebite victim’s body. European adder ( Vipera berus ) is considered as not very harmful …
THE SYSTEM OF SEROTONIN METABOLISM IN THE BRAIN OF RATS IN THE DEVELOPMENT OF GLUTAMATEINDUCED OBESITY AND ITS CORRECTION WITH NANOCRYSTALLINE CERIUM DIOXIDE Open
One of the causes of obesity is the body’s energy imbalance. The aim of our work was to investigate the serotonin system in the brain tissue of rats with glutamate-induced obesity and its correction with nanocrystalline cerium dioxide. The…
Muscle Tissue Response to Vipera berus berus and Vipera berus nikolskii Venoms: A Study on Matrix Metalloproteinases and Cytokine Modulation Open
Vipera berus, also known as the common adder, is a snake species widely distributed in Europe and parts of Asia. Its venom is a mix of enzymatic and non-enzymatic components causing both local and systemic effects including edema, hemorrha…
Abnormal proteolytic activity profile in plasma of blood donors according to anti-SARS-CoV-2 IgG titer Open
This work aims to study whether there is a relationship between titer values of anti-SARS-CoV-2 IgG and changes in proteolytic processes. To confirm this hypothesis, we analyzed the content and activity of Matrix Metalloproteinases (MMPs) …
Results of surgical treatment of chronic pancreatitis with a high risk of developing pancreatic cancer Open
Objective. To analyze the results of surgical treatment of patients with pancreatic insufficiency and a high risk of developing pancreatic cancer. Materials and methods. The study included 39 patients treated in 2019–2023. In 20 (51%) pati…
Proteolytic imbalance in plasma of patients with multiple sclerosis following COVID-19 Open
Background. The present research was conducted with the following objectives: 1) to determine the plasma levels of five matrix metalloproteinases (MMPs), namely MMP-1, -2, -3, -8, -10, and tissue inhibitor of metalloproteinase-1 (TIMP-1); …
Comparative analysis of Brassica carinata and fungal industrial lipases used for biodiesel production Open
Aim. To identify the genes of endogenous TAG-lipases in the genome of Abyssinian mustard, or carinata (Brassica carinata), and to analyze the similarity of their amino acid sequences with the industrial lipases of fungal origin. Methods. G…
Fish Hydrolysates as Potential Biostimulants for Growing Legumes and Cereals to Reduce Temperature Stress Open
Introduction This study aimed to develop an optimal method for the production of fish hydrolysates and to test their effectiveness as plant biostimulants under low-temperature growing conditions. Methods To obtain fish hydrolysates, the wa…
Secondary Prevention of Multifocal Atherosclerosis Combined with Chronic Obstructive Pulmonary Disease Open
The problem of secondary prevention of multifocal atherosclerosis (MAS) combined with chronic obstructive pulmonary disease (COPD), is a leading cause of death in the world. Therefore, the search for drugs capable of affecting the destruct…
COAGULATION AND ANTICOAGULATION PARAMETERS IN MULTIPLE SCLEROSIS PATIENTS WITH AND WITHOUT COVID-19 Open
The aim. To investigate plasma levels of main coagulation and fibrinolytic factors in MS patients with and without COVID-19 history. Materials and methods. A total of 127 participants were enrolled in this study, including 97 MS patients a…
Characteristics of fibrin/fibrinogen degradation products in multiple sclerosis following SARS-CoV-2 infection Open
Background. The purpose of this study was to investigate plasma levels of fibrinogen and products of its degradation in patients with multiple sclerosis (MS) with and without a history of coronavirus disease 2019 (COVID-19). Materials and …