Amy Schmid
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View article: Genomic re-sequencing reveals mutational divergence across genetically engineered strains of model archaea
Genomic re-sequencing reveals mutational divergence across genetically engineered strains of model archaea Open
Archaeal molecular biology has been a topic of intense research in recent decades as their role in global ecosystems, nutrient cycles, and eukaryotic evolution comes to light. The hypersaline-adapted archaeal species Halobacterium salinaru…
View article: Rapid rewiring of an archaeal transcription factor function via flexible cis-trans interactions
Rapid rewiring of an archaeal transcription factor function via flexible cis-trans interactions Open
For microbial cells, an appropriate response to changing environmental conditions is critical for viability. Transcription regulatory proteins, or transcription factors (TFs) sense environmental signals to change gene expression. However, …
View article: Halofilins as emerging bactofilin families of archaeal cell shape plasticity orchestrators
Halofilins as emerging bactofilin families of archaeal cell shape plasticity orchestrators Open
Bactofilins are rigid, nonpolar bacterial cytoskeletal filaments that link cellular processes to specific curvatures of the cytoplasmic membrane. Although homologs of bactofilins have been identified in archaea and eukaryotes, functional s…
View article: Genomic re-sequencing reveals mutational divergence across genetically engineered strains of model archaea
Genomic re-sequencing reveals mutational divergence across genetically engineered strains of model archaea Open
Because archaea are the evolutionary ancestors of eukaryotes, archaeal molecular biology has been a topic of intense recent research. The hypersaline adapted archaeal species Halobacterium salinarum and Haloferax volcanii serve as importan…
View article: A conserved transcription factor controls gluconeogenesis via distinct targets in hypersaline-adapted archaea with diverse metabolic capabilities
A conserved transcription factor controls gluconeogenesis via distinct targets in hypersaline-adapted archaea with diverse metabolic capabilities Open
Timely regulation of carbon metabolic pathways is essential for cellular processes and to prevent futile cycling of intracellular metabolites. In Halobacterium salinarum , a hypersaline adapted archaeon, a sugar-sensing TrmB family protein…
View article: <scp>TbsP</scp> and <scp>TrmB</scp> jointly regulate <i>gapII</i> to influence cell development phenotypes in the archaeon <i>Haloferax volcanii</i>
<span>TbsP</span> and <span>TrmB</span> jointly regulate <i>gapII</i> to influence cell development phenotypes in the archaeon <i>Haloferax volcanii</i> Open
Microbial cells must continually adapt their physiology in the face of changing environmental conditions. Archaea living in extreme conditions, such as saturated salinity, represent important examples of such resilience. The model salt‐lov…