Alexander Schramm
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View article: A computational model elucidates the effects of oncogene-induced expression alterations on the energy metabolism of neuroblastoma
A computational model elucidates the effects of oncogene-induced expression alterations on the energy metabolism of neuroblastoma Open
Alterations in energy metabolism are recognized as a hallmark of cancer. Experimental evidence shows that oncogenes play a key role in the reprogramming of metabolism. In neuroblastoma, the oncogene MYCN, a main risk factor of poor prognos…
View article: One-plate versus two-plate fixation in the treatment of mandibular angle fractures: a retrospective two-centre comparative study
One-plate versus two-plate fixation in the treatment of mandibular angle fractures: a retrospective two-centre comparative study Open
Background The treatment of mandibular angle fractures remains controversial, particularly regarding the method of fixation. The primary aim of this study was to compare surgical outcomes following treatment with 1-plate versus 2-plate fix…
View article: Stratifying Skin Cancer Patients and Guiding Treatment Decisions Through Combined p53 and p63 Expression Analysis
Stratifying Skin Cancer Patients and Guiding Treatment Decisions Through Combined p53 and p63 Expression Analysis Open
Distinct expression patterns of p53 and p63 suggest stage-specific roles in skin carcinogenesis. Elevated p53 in early lesions supports its tumor-suppressive function, while p63 may contribute to tumor maintenance in advanced stages. These…
View article: Datavzrd: Rapid programming- and maintenance-free interactive visualization and communication of tabular data
Datavzrd: Rapid programming- and maintenance-free interactive visualization and communication of tabular data Open
Tabular data, often scattered across multiple tables, is the primary output of data analyses in virtually all scientific fields. Exchange and communication of tabular data is therefore a central challenge. We present Datavzrd , a tool for …
View article: Retrospective evaluation of ocular injuries in fractures of the zygomaticoorbital complex in a level I trauma center: is primary specialized ophthalmologic examination always necessary?
Retrospective evaluation of ocular injuries in fractures of the zygomaticoorbital complex in a level I trauma center: is primary specialized ophthalmologic examination always necessary? Open
Purpose The necessity of a specialized ophthalmological assessment following fractures of the zygomaticoorbital (ZMO) complex in an emergency setting is still debated in resource-limited health systems. The primary aim of this study was to…
View article: Datavzrd: Rapid programming- and maintenance-free interactive visualization and communication of tabular data
Datavzrd: Rapid programming- and maintenance-free interactive visualization and communication of tabular data Open
Tabular data, often scattered across multiple tables, is the primary output of data analyses in virtually all scientific fields. Exchange and communication of tabular data is therefore a central challenge. We present Datavzrd , a tool for …
View article: NeoTRACK trial: Neoadjuvant TiRagolumab, Atezolizumab and Chemotherapy – dissection of IO- efficacy in NSCLC by longitudinal tracKing – protocol of a non-randomised, open-label, single-arm, phase II study
NeoTRACK trial: Neoadjuvant TiRagolumab, Atezolizumab and Chemotherapy – dissection of IO- efficacy in NSCLC by longitudinal tracKing – protocol of a non-randomised, open-label, single-arm, phase II study Open
Background Immunotherapies targeting the programmed death receptor-1/programmed death ligand-1(PD-1/PD-L1) checkpoint have a major impact on the treatment of both resectable and advanced non-small cell lung cancer (NSCLC). Additional block…
View article: A computational model elucidates the effect of oncogene induced expression alterations on the energy metabolism of neuroblastoma
A computational model elucidates the effect of oncogene induced expression alterations on the energy metabolism of neuroblastoma Open
An altered energy metabolism is recognized as a hallmark of cancer. Experimental evidence shows that oncogenes play a key role in the reprogramming of metabolism. In neuroblastoma the oncogene MYCN, a main risk factor of poor prognosis, ha…
View article: A MYCN-driven de-differentiation profile identifies a subgroup of aggressive retinoblastoma
A MYCN-driven de-differentiation profile identifies a subgroup of aggressive retinoblastoma Open
Retinoblastoma are childhood eye tumors arising from retinal precursor cells. Two distinct retinoblastoma subtypes with different clinical behavior have been described based on gene expression and methylation profiling. Using consensus clu…
View article: Assessment of anxiety in children during the COVID‐19 pandemic
Assessment of anxiety in children during the COVID‐19 pandemic Open
Objective This study assessed anxiety levels in children during the COVID‐19 pandemic and explored how factors related to COVID‐19 may have affected the prevalence of anxiety disorders among the pediatric population. Methods Childhood anxi…
View article: Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer: a randomized phase 2 trial
Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer: a randomized phase 2 trial Open
Antibodies targeting the immune checkpoint molecules PD-1, PD-L1 and CTLA-4, administered alone or in combination with chemotherapy, are the standard of care in most patients with metastatic non-small-cell lung cancers. When given before c…
View article: Influence of analytical procedures on miRNA expression analyses in saliva samples
Influence of analytical procedures on miRNA expression analyses in saliva samples Open
Aim of this study was to demonstrate the influence of different analytical procedures and techniques on the resulting miRNA expression profile in healthy control subjects and tumor patients using the oral squamous cell carcinoma (OSCC) mod…
View article: Evaluation of Five-year Overall Survival Rates Among 18,331 Head and Neck Cancer Patients Exposed to Different Targeted Therapies Through Real-world Data in a Case-controlled Study
Evaluation of Five-year Overall Survival Rates Among 18,331 Head and Neck Cancer Patients Exposed to Different Targeted Therapies Through Real-world Data in a Case-controlled Study Open
EGFR inhibitors are one of the most frequently used targeted therapies in HNC. However, in the present analysis, a survival advantage of patients treated with c-MET inhibitors or VEGF inhibitors was observed compared to those treated with …
View article: Extracranial Hypoglossal Schwannoma: Case Report and Literature Review
Extracranial Hypoglossal Schwannoma: Case Report and Literature Review Open
Accurate diagnosis of this rare clinical entity requires comprehensive diagnostics. The optimal therapeutic strategy is nerve-sparing surgical excision, although it can be challenging.
View article: Successful Desensitization with Imlifidase and Daratumumab in a Highly Immunized, Crossmatch Positive, Blood Group-Incompatible Living-Donor Re-Transplant Recipient with Systemic Lupus Erythematosus and Antiphospholipid Syndrome
Successful Desensitization with Imlifidase and Daratumumab in a Highly Immunized, Crossmatch Positive, Blood Group-Incompatible Living-Donor Re-Transplant Recipient with Systemic Lupus Erythematosus and Antiphospholipid Syndrome Open
Introduction: The transplantation of highly sensitized patients remains a major obstacle. Immunized patients wait longer for a transplant if not prioritized, and if transplanted, their transplant outcome is worse. Case Presentation: We rep…
View article: Elevating Precision Oncology: Unraveling the Role of microRNA Analysis in the Comprehensive Staging of Oral Cavity Carcinoma
Elevating Precision Oncology: Unraveling the Role of microRNA Analysis in the Comprehensive Staging of Oral Cavity Carcinoma Open
This letter emphasizes the potential of microRNA (miRNA) analysis in the staging of oral cavity carcinoma. It highlights the role of miRNA analysis in predicting critical aspects, such as lymphonodular recurrence, preoperative tumor gradin…
View article: Comprehensive pan-cancer analysis of cfDNA methylation marks in tumors reveals complex epigenetic regulatory circuits and diagnostic biomarkers
Comprehensive pan-cancer analysis of cfDNA methylation marks in tumors reveals complex epigenetic regulatory circuits and diagnostic biomarkers Open
DNA methylation is an extensively studied, stable, and fundamental epigenetic alteration in most cancer types 1 . Single-base-pair resolution analyses of DNA methylation is currently feasible 2 . Analysis of DNA methylation, in liquid biop…
View article: The Multifaceted Roles of Lamins in Lung Cancer and DNA Damage Response
The Multifaceted Roles of Lamins in Lung Cancer and DNA Damage Response Open
Emerging evidence suggests that lamin functions are not limited to maintaining the structural integrity of the nucleus in eukaryotic cells but that these functions affect many facets of cancer biology. An increasing number of reports sugge…
View article: Comparison of the Effective Radiation Dose in the Region of the Facial Skull Between Multidetector CT, Dental Conebeam CT and Intraoperative 3D C-Arms
Comparison of the Effective Radiation Dose in the Region of the Facial Skull Between Multidetector CT, Dental Conebeam CT and Intraoperative 3D C-Arms Open
Study Design Experimental single-centre study of X-ray absorption using a phantom skull. Objective This experimental study aimed to compare the radiation doses of different 3D imaging devices used in maxillofacial surgery, including one Mu…
View article: Chernobyl’s Aftermath: Multiple Manifestations of Basalioma in a Patient after Radioactive Contamination in 1986
Chernobyl’s Aftermath: Multiple Manifestations of Basalioma in a Patient after Radioactive Contamination in 1986 Open
Background: The Chernobyl nuclear disaster is still considered the worst nuclear accident in history. The particles were dispersed over the former USSR and large parts of Western Europe, leading to radioactive exposure to more than 10 mill…
View article: Prosthetically guided oral implant surgery. A retrospective cohort study evaluating the 5-year surgical outcome
Prosthetically guided oral implant surgery. A retrospective cohort study evaluating the 5-year surgical outcome Open
Purpose: This study primarily evaluated the 5-year implant survival and success rate of prosthetically guided inserted implants. The secondary aim was to evaluate the impact of clinical variables on the development of mucositis, peri-impla…
View article: Accuracy Analysis of Computer-Assisted and Guided Dental Implantology by Comparing 3D Planning Data and Actual Implant Placement in a Mandibular Training Model: A Monocentric Comparison between Dental Students and Trained Implantologists
Accuracy Analysis of Computer-Assisted and Guided Dental Implantology by Comparing 3D Planning Data and Actual Implant Placement in a Mandibular Training Model: A Monocentric Comparison between Dental Students and Trained Implantologists Open
The aim of this study was to investigate how precisely implantation can be realized by participants on a phantom head according to preliminary planning. Of particular interest here was the influence of participants’ previous knowledge and …
View article: Surface Chemistry and Specific Surface Area Rule the Efficiency of Gold Nanoparticle Sensitizers in Proton Therapy
Surface Chemistry and Specific Surface Area Rule the Efficiency of Gold Nanoparticle Sensitizers in Proton Therapy Open
Gold nanoparticles (AuNPs) are currently the most studied radiosensitizers in proton therapy (PT) applicable for the treatment of solid tumors, where they amplify production of reactive oxygen species (ROS). However, it is underexplored ho…
View article: Comparison of Anatomical Preformed Titanium Implants and Patient-Specific CAD/CAM Implants in the Primary Reconstruction of Isolated Orbital Fractures—A Retrospective Study
Comparison of Anatomical Preformed Titanium Implants and Patient-Specific CAD/CAM Implants in the Primary Reconstruction of Isolated Orbital Fractures—A Retrospective Study Open
Background/Aim: Reconstruction of the fractured orbit remains a challenge. The aim of this study was to compare anatomical preformed titanium orbital implants with patient-specific CAD/CAM implants for precision and intraoperative applicab…
View article: Dental Root Injuries Caused by Osteosynthesis Screws in Orthognathic Surgery—Comparison of Conventional Osteosynthesis and Osteosynthesis by CAD/CAM Drill Guides and Patient-Specific Implants
Dental Root Injuries Caused by Osteosynthesis Screws in Orthognathic Surgery—Comparison of Conventional Osteosynthesis and Osteosynthesis by CAD/CAM Drill Guides and Patient-Specific Implants Open
Background/Aim: The primary aim was to evaluate the prevalence and localisation of dental injuries caused by osteosynthesis screws during orthognathic surgery, comparing two different CAD/CAM planning/surgical approaches through retrospect…