Anne Spang
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View article: A multichaperone condensate enhances protein folding in the endoplasmic reticulum
A multichaperone condensate enhances protein folding in the endoplasmic reticulum Open
Protein folding in the endoplasmic reticulum (ER) relies on a network of molecular chaperones that facilitates the folding and maturation of client proteins. How the ER chaperones organize in a supramolecular manner to exert their cooperat…
View article: A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis
A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis Open
Clathrin-mediated endocytosis (CME) is crucial for regulating G protein-coupled receptors (GPCRs) via phosphorylation-dependent arrestin interactions. Despite detailed structural knowledge on the arrestin interactions with phosphorylated t…
View article: A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis
A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis Open
Clathrin-mediated endocytosis (CME) is crucial for regulating G protein-coupled receptors (GPCRs) via phosphorylation-dependent arrestin interactions. Despite detailed structural knowledge on the arrestin interactions with phosphorylated t…
View article: Arrestin recognizes GPCRs independently of the receptor state
Arrestin recognizes GPCRs independently of the receptor state Open
Only two nonvisual arrestins recognize many hundreds of different, intracellularly phosphorylated G protein-coupled receptors (GPCRs). Due to the highly dynamic nature of GPCR•arrestin complexes, the critical determinants of GPCR–arrestin …
View article: ESCRTing the RABs through conversion
ESCRTing the RABs through conversion Open
The endosomal system is essential for the intra- and intercellular communication in cells and multicellular organisms. It is involved in the secretion of signaling factors and serves as a venue for signaling receptors from the plasma membr…
View article: Nonstop mutations cause loss of renal tumor suppressor proteins <i>VHL</i> and <i>BAP1</i> and affect multiple stages of protein translation
Nonstop mutations cause loss of renal tumor suppressor proteins <i>VHL</i> and <i>BAP1</i> and affect multiple stages of protein translation Open
Nonstop extension or stop-loss mutations lead to the extension of a protein at its carboxyl terminus. Recently, nonstop mutations in the tumor suppressor SMAD Family Member 4 ( SMAD4 ) have been discovered to lead to proteasomal SMAD4 degr…
View article: A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis
A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis Open
Clathrin-mediated endocytosis (CME) is crucial for regulating G protein-coupled receptors (GPCRs) via phosphorylation-dependent arrestin interactions. Despite detailed structural knowledge on the arrestin interactions with phosphorylated t…
View article: Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis
Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis Open
Deleterious mutations in the lipopolysaccharide responsive beige-like anchor protein (LRBA) gene cause severe childhood immune dysregulation. The complexity of the symptoms involving multiple organs and the broad range of unpredictable cli…
View article: A functional chaperone condensate in the endoplasmic reticulum
A functional chaperone condensate in the endoplasmic reticulum Open
One third of eukaryotic proteins are processed within the endoplasmic reticulum (ER) to obtain their correct structure1-3. This function is ensured by a network of molecular chaperones that recognizes client proteins and assists their fold…
View article: Ribosomal protein RPL39L is an efficiency factor in the cotranslational folding of a subset of proteins with alpha helical domains
Ribosomal protein RPL39L is an efficiency factor in the cotranslational folding of a subset of proteins with alpha helical domains Open
Increasingly many studies reveal how ribosome composition can be tuned to optimally translate the transcriptome of individual cell types. In this study, we investigated the expression pattern, structure within the ribosome and effect on pr…
View article: Arrestin recognizes GPCRs independently of the receptor state
Arrestin recognizes GPCRs independently of the receptor state Open
Only two non-visual arrestins recognize many hundreds of different, intracellularly phosphorylated G protein-coupled receptors (GPCRs). Due to the highly dynamic nature of GPCR•arrestin complexes, the critical determinants of GPCR-arrestin…
View article: Coordination between ESCRT function and Rab conversion during endosome maturation
Coordination between ESCRT function and Rab conversion during endosome maturation Open
The endosomal pathway is essential for regulating cell signaling and cellular homeostasis. Rab5-positive early endosomes receive proteins from the plasma membrane. Dependent on a ubiquitin mark on the protein, they will be either recycled …
View article: Bacterial RNA promotes proteostasis through inter-tissue communication in<i>C. elegans</i>
Bacterial RNA promotes proteostasis through inter-tissue communication in<i>C. elegans</i> Open
Life expectancy has been increasing over the last decades, which is not matched by an increase in healthspan. Besides genetic composition, environmental and nutritional factors influence both health- and lifespan. Diet is thought to be a m…
View article: Endosomal LRBA regulates the endo-lysosomal pathway
Endosomal LRBA regulates the endo-lysosomal pathway Open
Deleterious mutations in the LRBA (Lipopolysaccharide Responsive Beige-like Anchor protein) gene cause severe childhood immune dysregulation. The clinical manifestations of LRBA deficiency syndrome are highly variable. Thus, the complexity…
View article: The protein tyrosine phosphatase <scp>PPH</scp> ‐7 is required for fertility and embryonic development in <i>C. elegans</i> at elevated temperatures
The protein tyrosine phosphatase <span>PPH</span> ‐7 is required for fertility and embryonic development in <i>C. elegans</i> at elevated temperatures Open
Post‐translational modifications are key in the regulation of activity, structure, localization, and stability of most proteins in eukaryotes. Phosphorylation is potentially the most studied post‐translational modification, also due to its…
View article: Functional interplay of lipid droplets and mitochondria
Functional interplay of lipid droplets and mitochondria Open
Our body stores energy mostly in form of fatty acids (FAs) in lipid droplets (LDs). From there the FAs can be mobilized and transferred to peroxisomes and mitochondria. This transfer is dependent on close opposition of LDs and mitochondria…
View article: The ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria
The ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria Open
Most mitochondrial proteins are synthesized on cytosolic ribosomes and imported into mitochondria in a post-translational reaction. Mitochondrial precursor proteins which use the ER-SURF pathway employ the surface of the endoplasmic reticu…
View article: Arf1 coordinates fatty acid metabolism and mitochondrial homeostasis
Arf1 coordinates fatty acid metabolism and mitochondrial homeostasis Open
Lipid mobilization through fatty acid β-oxidation is a central process essential for energy production during nutrient shortage. In yeast, this catabolic process starts in the peroxisome from where β-oxidation products enter mitochondria a…
View article: Ribosomal protein RPL39L is an efficiency factor in the cotranslational folding of proteins with alpha helical domains
Ribosomal protein RPL39L is an efficiency factor in the cotranslational folding of proteins with alpha helical domains Open
Supplementary materials for the paper "Ribosomal protein RPL39L is an efficiency factor in the cotranslational folding of proteins with alpha helical domains". Analysis of public RNA-seq data The files named "RPL39L_public_rna_seq*" are re…
View article: Ribosomal protein RPL39L is an efficiency factor in the cotranslational folding of proteins with alpha helical domains
Ribosomal protein RPL39L is an efficiency factor in the cotranslational folding of proteins with alpha helical domains Open
Increasingly many studies reveal how ribosome composition can be tuned to optimally translate the transcriptome of individual cell types. In this study, we investigated the expression pattern, structure within the ribosome and effect on pr…
View article: Genetic analysis of<i>rab7</i>mutants in zebrafish
Genetic analysis of<i>rab7</i>mutants in zebrafish Open
Vascular network formation requires the fusion of newly formed blood vessels and the emergence of a patent lumen between the newly established connections so that blood flow can start. Lumen formation has been shown to depend on the late e…
View article: Membrane tethers at a glance
Membrane tethers at a glance Open
Cargo delivery from one compartment to the next relies on the fusion of vesicles with different cellular organelles in a process that requires the concerted action of tethering factors. Although all tethers act to bridge vesicle membranes …
View article: Protein sorting from endosomes to the TGN
Protein sorting from endosomes to the TGN Open
Retrograde transport from endosomes to the trans-Golgi network is essential for recycling of protein and lipid cargoes to counterbalance anterograde membrane traffic. Protein cargo subjected to retrograde traffic include lysosomal acid-hyd…
View article: Sorting of cargo in the tubular endosomal network
Sorting of cargo in the tubular endosomal network Open
Intercellular communication is an essential process in all multicellular organisms. During this process, molecules secreted by one cell will bind to a receptor on the cognate cell leading to the subsequent uptake of the receptor‐ligand com…
View article: FERARI and cargo adaptors coordinate cargo flow through sorting endosomes
FERARI and cargo adaptors coordinate cargo flow through sorting endosomes Open
Cellular organization, compartmentalization and cell-to-cell communication are crucially dependent on endosomal pathways. Sorting endosomes provide a transit point for various trafficking pathways and decide the fate of proteins: recycling…