Emina A. Stojković
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View article: Ultrafast, remote-controlled protonation reaction enables structural changes in a phytochrome
Ultrafast, remote-controlled protonation reaction enables structural changes in a phytochrome Open
In photoactive proteins, coupling between the chromophore and protein matrix is exquisitely tuned. Proton transfer reactions can mediate this coupling, as in proton-coupled electron transfer and excited-state proton transfer. Additional me…
View article: Photoactivation in Myxobacterial Phytochrome: Early Events
Photoactivation in Myxobacterial Phytochrome: Early Events Open
Myxobacteria are non-photosynthetic, soil bacteria distinguished by a multicellular stage in their life cycle known as fruiting bodies. Stimulated by light, fruiting bodies from myxobacteria may rely on phytochrome function as protein phot…
View article: Milestones in the development of <i>Myxococcus xanthus</i> as a model multicellular bacterium
Milestones in the development of <i>Myxococcus xanthus</i> as a model multicellular bacterium Open
From the humblest of beginnings (i.e. a pile of dry cow dung) over 80 years ago, the Gram-negative bacterium Myxococcus xanthus has emerged as a premier model system for studying diverse fields of bacteriology, including multicellular deve…
View article: Observation of early events in the photoactivation of Myxobacterial phytochrome using time-resolved serial femtosecond crystallography
Observation of early events in the photoactivation of Myxobacterial phytochrome using time-resolved serial femtosecond crystallography Open
Myxobacteria are non-photosynthetic, soil-dwelling bacteria distinguished by a multicellular stage in their life cycle known as fruiting bodies that are stimulated by light. Myxobacterial phytochromes are candidates for the perception of r…
View article: Structures of myxobacterial phytochrome revealed by cryo-EM using the Spotiton technique and with x-ray crystallography
Structures of myxobacterial phytochrome revealed by cryo-EM using the Spotiton technique and with x-ray crystallography Open
Phytochromes are red-light photoreceptors first identified in plants, with homologs found in bacteria and fungi, that regulate a variety of critical physiological processes. They undergo a reversible photocycle between two distinct states:…
View article: Exploiting fourth-generation synchrotron radiation for enzyme and photoreceptor characterization
Exploiting fourth-generation synchrotron radiation for enzyme and photoreceptor characterization Open
The upgrade of the European Synchrotron Radiation Facility (ESRF) in Grenoble, France to an Extremely Brilliant Source (EBS) is expected to enable time-resolved synchrotron serial crystallography (SSX) experiments with sub-millisecond time…
View article: Photomorphogenesis of Myxococcus macrosporus: new insights for light-regulation of cell development
Photomorphogenesis of Myxococcus macrosporus: new insights for light-regulation of cell development Open
Myxobacteria are non-photosynthetic bacteria distinguished among prokaryotes by a multicellular stage in their life cycle known as fruiting bodies that are formed in response to nutrient deprivation and stimulated by light. Here, we report…
View article: Photoreception and signaling in bacterial phytochrome revealed by single-particle cryo-EM
Photoreception and signaling in bacterial phytochrome revealed by single-particle cryo-EM Open
Phytochromes are red-light photoreceptors discovered in plants with homologs in bacteria and fungi that regulate a variety of physiological responses. They display a reversible photocycle between two distinct states: a red-light–absorbing …
View article: Directed ultrafast conformational changes accompany electron transfer in a photolyase as resolved by serial crystallography
Directed ultrafast conformational changes accompany electron transfer in a photolyase as resolved by serial crystallography Open
Charge-transfer reactions in proteins are important for life, such as in photolyases which repair DNA, but the role of structural dynamics remains unclear. Here, using femtosecond X-ray crystallography, we report the structural changes tha…
View article: Blue and red in the protein world: Photoactive yellow protein and phytochromes as revealed by time-resolved crystallography
Blue and red in the protein world: Photoactive yellow protein and phytochromes as revealed by time-resolved crystallography Open
Time-resolved crystallography (TRX) is a method designed to investigate functional motions of biological macromolecules on all time scales. Originally a synchrotron-based method, TRX is enabled by the development of TR Laue crystallography…
View article: Signal Transduction in an Enzymatic Photoreceptor Revealed by Cryo-Electron Microscopy
Signal Transduction in an Enzymatic Photoreceptor Revealed by Cryo-Electron Microscopy Open
Phytochromes are essential photoreceptor proteins in plants with homologs in bacteria and fungi that regulate a variety of important environmental responses. They display a reversible photocycle between two distinct states, the red-light a…
View article: Two-photon Absorption and Photoionization of a Bacterial Phytochrome
Two-photon Absorption and Photoionization of a Bacterial Phytochrome Open
Phytochromes constitute a family of photosensory proteins that are utilized by various organisms to regulate several physiological processes. Phytochromes bind a bilin pigment that switches its isomeric state upon absorption of red or far-…
View article: Heterogeneity in the M. tuberculosis β-Lactamase Inhibition by Sulbactam
Heterogeneity in the M. tuberculosis β-Lactamase Inhibition by Sulbactam Open
For decades, researchers have been determined to elucidate essential enzymatic functions on the atomic lengths scale by tracing atomic positions in real time. Our work builds on new possibilities unleashed by mix-and-inject serial crystall…
View article: Heterogeneity in the<i>M. tuberculosis</i>β-lactamase inhibition by Sulbactam
Heterogeneity in the<i>M. tuberculosis</i>β-lactamase inhibition by Sulbactam Open
For decades, researchers have been determined to elucidate essential enzymatic functions on the atomic lengths scale by tracing atomic positions in real time. Our work builds on new possibilities unleashed by mix-and-inject serial crystall…
View article: On the Role of the Conserved Histidine at the Chromophore Isomerization Site in Phytochromes
On the Role of the Conserved Histidine at the Chromophore Isomerization Site in Phytochromes Open
Phytochromes are sensory photoreceptors that use light to drive protein structural changes, which in turn trigger physiological reaction cascades. The process starts with a double-bond photoisomerization of the linear methine-bridged tetra…
View article: The three-dimensional structure of <i>Drosophila melanogaster</i> (6–4) photolyase at room temperature
The three-dimensional structure of <i>Drosophila melanogaster</i> (6–4) photolyase at room temperature Open
(6–4) photolyases are flavoproteins that belong to the photolyase/cryptochrome family. Their function is to repair DNA lesions using visible light. Here, crystal structures of Drosophila melanogaster (6–4) photolyase [ Dm (6–4)photolyase] …
View article: A Unifying Framework for Understanding Biological Structures and Functions Across Levels of Biological Organization
A Unifying Framework for Understanding Biological Structures and Functions Across Levels of Biological Organization Open
The relationship between structure and function is a major constituent of the rules of life. Structures and functions occur across all levels of biological organization. Current efforts to integrate conceptual frameworks and approaches to …
View article: Vitamin C Binds to SARS Coronavirus-2 Main Protease Essential for Viral Replication
Vitamin C Binds to SARS Coronavirus-2 Main Protease Essential for Viral Replication Open
There is an urgent need for anti-viral agents that treat and/or prevent Covid-19 caused by SARS-Coronavirus (CoV-2) infections. The replication of the SARS CoV-2 is dependent on the activity of two cysteine proteases, a papain-like proteas…
View article: High-resolution Crystal Structures of Transient Intermediates in the Phytochrome Photocycle
High-resolution Crystal Structures of Transient Intermediates in the Phytochrome Photocycle Open
Phytochromes are red/far-red light photoreceptors in bacteria to plants, which elicit a variety of important physiological responses. They display a reversible photocycle between the resting (dark) Pr state and the light activated Pfr stat…
View article: Ebselen Reacts with SARS Coronavirus-2 Main Protease Crystals
Ebselen Reacts with SARS Coronavirus-2 Main Protease Crystals Open
The SARS coronavirus 2 main protease 3CLpro tailor cuts various essential virus proteins out of long poly-protein translated from the virus RNA. If the 3CLpro is inhibited, the functional virus proteins cannot form and the virus cannot rep…
View article: The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser
The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser Open
Phytochrome proteins control the growth, reproduction, and photosynthesis of plants, fungi, and bacteria. Light is detected by a bilin cofactor, but it remains elusive how this leads to activation of the protein through structural changes.…
View article: Author response: The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser
Author response: The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Phytochrome proteins control …
View article: The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser
The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser Open
Phytochrome proteins control the growth, reproduction, and photosynthesis of plants, fungi, and bacteria. Light is detected by a bilin cofactor, but it remains elusive how this leads to activation of the protein through structural changes.…
View article: High-resolution crystal structures of a myxobacterial phytochrome at cryo and room temperatures
High-resolution crystal structures of a myxobacterial phytochrome at cryo and room temperatures Open
Phytochromes (PHYs) are photoreceptor proteins first discovered in plants, where they control a variety of photomorphogenesis events. PHYs as photochromic proteins can reversibly switch between two distinct states: a red light (Pr) and a f…