Roger A. Sunde
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Effect of graded levels of selenium supplementation as selenite on expression of selenosugars, selenocysteine, and other selenometabolites in rat liver Open
Using high pressure liquid chromatography (HPLC) coupled with selenium-specific inductively coupled plasma mass spectrometry (ICP–MS) and molecule specific (Orbitrap MS/MS) detection, we previously found that far more selenium (Se) is pres…
Selenomethionine supplementation and expression of selenosugars, selenocysteine, and other selenometabolites in rat liver Open
Selenomethionine (SeMet) as a methionine analog can be incorporated into protein. In turkeys, we recently found that selenium (Se) as selenite is not metabolized to SeMet but rather to selenosugars (seleno-N-acetyl galactosamine) bound to …
Metabolism of Tracer 75Se Selenium From Inorganic and Organic Selenocompounds Into Selenoproteins in Rats, and the Missing 75Se Metabolites Open
We now know much about selenium (Se) incorporation into selenoproteins, and there is considerable interest in the optimum form of Se for supplementation and prevention of cancer. To study the flux of 75 Se into selenoprotein, rats were fed…
GSEA of liver transcripts in turkeys fed 2 or 1 μg Se/g vs. 0.4 μg Se/g. Open
Shown are resulting enrichment plots (left) and fold-change heat maps (right) for resulting leading-edge genes. (A) KEGG ribosome gene set for 2 μg Se/g; (B) KEGG glyoxylate and dicarboxylate gene set for 2 μg Se/g; (C) KEGG tight junction…
The hepatic transcriptome of the turkey poult (Meleagris gallopavo) is minimally altered by high inorganic dietary selenium Open
There is interest in supplementing animals and humans with selenium (Se) above Se-adequate levels, but the only good biomarker for toxicity is tissue Se. We targeted liver because turkeys fed 5 μg Se/g have hepatic Se concentrations 6-fold…
GSEA of liver transcripts in high-Se turkeys fed 5 μg Se/g vs. 0.4 μg Se/g. Open
Shown are resulting enrichment plots (left) and fold-change heat maps (right) for resulting leading-edge genes. (A) Hallmark cholesterol homeostasis gene set; (B) Hallmark pancreatic β-cell gene set; (C) Hallmark fatty acid metabolism gene…
Correction: Identification and determination of selenocysteine, selenosugar, and other selenometabolites in turkey liver Open
Correction for ‘Identification and determination of selenocysteine, selenosugar, and other selenometabolites in turkey liver’ by Katarzyna Bierla et al., Metallomics, 2020, DOI: 10.1039/d0mt00040j.
Identification and determination of selenocysteine, selenosugar, and other selenometabolites in turkey liver Open
Liver and other tissues accumulate selenium (Se) when animals are supplemented with high dietary Se as inorganic Se. To further study selenometabolites in Se-deficient, Se-adequate, and high-Se liver, turkey poults were fed 0, 0.4, and 5 μ…
PSIII-24 Selenium requirement of turkeys based on tissue selenium concentration and selenoprotein activity and transcript expression Open
Selenium (Se) is an essential and toxic trace mineral in animal diets. The current NRC turkey Se requirement is 0.2 µg Se/g diet for all life stages, higher than the published rat and mouse requirements. The studies that form the basis for…
High dietary inorganic selenium has minimal effects on turkeys and selenium status biomarkers Open
The current NRC turkey Se requirement is 0.2 μg Se/g diet. Recent studies evaluating tissue Se, glutathione peroxidase (GPX) activities, and selenoprotein transcript expression concluded that the dietary Se requirement of the turkey poult …
Selenium regulation of selenoprotein enzyme activity and transcripts in a pilot study with Founder strains from the Collaborative Cross Open
Rodents and humans have 24-25 selenoproteins, and these proteins contain the 21st amino acid, selenocysteine, incorporated co-translationally into the peptide backbone in a series of reactions dependent on at least 6 unique gene products. …
Selenium requirements based on muscle and kidney selenoprotein enzyme activity and transcript expression in the turkey poult (Meleagris gallopavo) Open
The current NRC selenium (Se) requirement for turkeys is 0.2 μg Se/g diet. We previously fed turkey poults a Se-deficient diet (0.005 μg Se/g) supplemented with 10 graded levels of Se (0, 0.025, 0.05, 0.1, 0.2, 0.3, 0.4, 0.5, 0.75, 1.0 μg …
Selenoprotein Transcript Level and Enzyme Activity as Biomarkers for Selenium Status and Selenium Requirements of Chickens (Gallus gallus) Open
The NRC selenium (Se) requirement for broiler chicks is 0.15 μg Se/g diet, based primarily on weight gain and feed intake studies reported in 1986. To determine Se requirements in todayâs rapidly growing broiler chick, day-old male chic…
Selenoprotein Transcript Level and Enzyme Activity as Biomarkers for Selenium Status and Selenium Requirements in the Turkey (Meleagris gallopavo) Open
The current National Research Council (NRC) selenium (Se) requirement for the turkey is 0.2 μg Se/g diet. The sequencing of the turkey selenoproteome offers additional molecular biomarkers for assessment of Se status. To determine dietary …