Alice L. Yu
YOU?
Author Swipe
Valuation of the EQ-5D-Y-5L Using DCE Methods That Account for Nonlinear Time Preferences Open
Objectives Discrete choice experiment (DCE) methods that account for nonlinear time preferences have been tested in adult EQ-5D instruments but have yet to be tested for the valuation of EQ-5D-Y instruments. The aims of this study were to …
383 Adamantinoma-Like Ewing Sarcoma Mimicking Poorly Differentiated Squamous Cell Carcinoma in the Larynx: A Diagnostic Pitfall and Literature Review Open
Introduction/Objective ALES is a recently recognized, rare subtype of Ewing sarcoma that shows overlapping features with basaloid carcinomas, particularly in the head and neck region. It is defined by EWSR1 gene rearrangements and complex …
View article: Landscape of paediatric oncology clinical trials in Asia
Landscape of paediatric oncology clinical trials in Asia Open
In this second paper of a Series on childhood cancer in Asia, we provide an overview on the Paediatric Oncology Clinical Trials in Asia. Asia with a population of 4.7 billion constitutes about 60% of the world's population. The continent a…
View article: YULINK deficiency promotes cell death under glucose restriction in HCC cells in association with GLUT1-mediated glycolysis
YULINK deficiency promotes cell death under glucose restriction in HCC cells in association with GLUT1-mediated glycolysis Open
Background Through evolutionary genomics analysis, we identified Yulink (MIOS, Entrez Gene: 54,468), a highly conserved gene encoding an 875 amino acid protein with diverse functions in humans. Given the importance of accelerated glycolysi…
View article: Prevalence of vasculitis, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, idiopathic inflammatory myopathies and spondyloarthritis in <scp>Australia</scp> : a systematic review and meta‐analysis
Prevalence of vasculitis, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, idiopathic inflammatory myopathies and spondyloarthritis in <span>Australia</span> : a systematic review and meta‐analysis Open
Background Systemic autoimmune rheumatic diseases (SARDs), including vasculitis, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), idiopathic inflammatory myopathies (IIM), spondyloarthritis (SpA), Sj…
How Do Different Health States Impact Preferences for Social-Care-Related Quality of Life: An Exploration of EQ-5D-5L and Adult Social Care Outcomes Toolkit Using a Vignette Approach Open
This study found limited influence of health context on valuation of social-care-related quality-of-life dimensions, providing evidence supporting development of ASCOT value sets independent of context.
Robotic radical cystectomy, bilateral pelvic lymph node dissection and creation of intracorporeal ileal conduit in a woman with severe obesity Open
OBJECTIVES: Some patients undergoing radical cystectomy may benefit more than others from robot-assisted surgery. In overweight patients, open cystectomy can be particularly challenging, and these cases may be better suited for a robotic a…
Tumor‐Associated Glycan Exploits Adenosine Receptor 2A Signaling to Facilitate Immune Evasion Open
Adenosine signaling is a crucial immunosuppressive pathway within the tumor microenvironment, making it a promising target for cancer therapy. In this study, it is demonstrated that Globo H ceramide (GHCer), the most prevalent tumor‐associ…
ST3GAL1 regulates cancer cell migration through crosstalk between EGFR and neuropilin-1 signaling Open
Metastasis is a major cause of cancer-related morbidity and mortality. The overexpression of the sialyltransferase ST3GAL1 in breast cancer correlates with metastasis. However, the molecular mechanisms underlying the effect of ST3GAL1 on c…
View article: Racial and Ethnic Survival Disparities Among Children With High-Risk Neuroblastoma
Racial and Ethnic Survival Disparities Among Children With High-Risk Neuroblastoma Open
Importance Whether population-based racial and ethnic survival disparities for children with high-risk neuroblastoma persist in the clinical trial setting is unknown. Objective To investigate racial and ethnic survival disparities among ch…
Bioactivities and Anti-Cancer Activities of NKT-Stimulatory Phenyl-Glycolipid Formulated with a PEGylated Lipid Nanocarrier Open
These findings demonstrate that the newly formulated PLN-C34 retains NKT-stimulatory activity and anti-cancer efficacy of C34, supporting the potential of PLN as a solvent for C34 for further development in cancer therapy.
Effective suppression of tumor growth and hepatic metastasis of neuroblastoma by NKT-stimulatory phenyl glycolipid Open
Invariant natural killer T cell (iNKT) cells produce large amounts of cytokines in response to α-Galactosylceramide (α-GalCer) stimulation. An analog containing two phenyl rings on the acyl chain, C34, was previously found to be more Th1-b…
View article: Current Challenges of Asian National Children's Cancer Study Groups on Behalf of Asian Pediatric Hematology and Oncology Group
Current Challenges of Asian National Children's Cancer Study Groups on Behalf of Asian Pediatric Hematology and Oncology Group Open
In Asia, a few countries have a long and established history of collaborative clinical trials successfully formed national children's cancer study groups, but many still do not have such groups. The process of forming national children's c…
Whole genomic analysis reveals atypical non-homologous off-target large structural variants induced by CRISPR-Cas9-mediated genome editing Open
CRISPR-Cas9 genome editing has promising therapeutic potential for genetic diseases and cancers, but safety could be a concern. Here we use whole genomic analysis by 10x linked-read sequencing and optical genome mapping to interrogate the …
View article: Impact of diagnostic and end‐of‐induction Curie scores with tandem high‐dose chemotherapy and autologous transplants for metastatic high‐risk neuroblastoma: A report from the Children's Oncology Group
Impact of diagnostic and end‐of‐induction Curie scores with tandem high‐dose chemotherapy and autologous transplants for metastatic high‐risk neuroblastoma: A report from the Children's Oncology Group Open
Background Diagnostic mIBG (meta‐iodobenzylguanidine) scans are an integral component of response assessment in children with high‐risk neuroblastoma. The role of end‐of‐induction (EOI) Curie scores (CS) was previously described in patient…
View article: Data from Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer
Data from Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer Open
Altered glycosylations, which are associated with expression and activities of glycosyltransferases, can dramatically affect the function of glycoproteins and modify the behavior of tumor cells. ST3GAL1 is a sialyltransferase that adds sia…
View article: Data from Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer
Data from Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer Open
Altered glycosylations, which are associated with expression and activities of glycosyltransferases, can dramatically affect the function of glycoproteins and modify the behavior of tumor cells. ST3GAL1 is a sialyltransferase that adds sia…
View article: Supplementary Figures from Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer
Supplementary Figures from Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer Open
Supplementary figure S1-S5
View article: Supplementary Figures from Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer
Supplementary Figures from Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer Open
Supplementary figure S1-S5
View article: De-identified ID of the patients included in the RG cohort from <i>GFPT2</i>-Expressing Cancer-Associated Fibroblasts Mediate Metabolic Reprogramming in Human Lung Adenocarcinoma
De-identified ID of the patients included in the RG cohort from <i>GFPT2</i>-Expressing Cancer-Associated Fibroblasts Mediate Metabolic Reprogramming in Human Lung Adenocarcinoma Open
This supplement file contains a list of de-identified IDs of the patients included in the RG cohort data available online.
View article: Supplementary Information from Long-Term Follow-up of a Phase III Study of ch14.18 (Dinutuximab) + Cytokine Immunotherapy in Children with High-Risk Neuroblastoma: COG Study ANBL0032
Supplementary Information from Long-Term Follow-up of a Phase III Study of ch14.18 (Dinutuximab) + Cytokine Immunotherapy in Children with High-Risk Neuroblastoma: COG Study ANBL0032 Open
Figure S1a, Figure S1b; Supplementary Tables S1-S7