Akihide Tanimoto
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View article: 10104-GEN-3Quantitative Methylation Analysis of the Glioblastoma MGMT Promoter by BSAS and Its Clinical Significance
10104-GEN-3Quantitative Methylation Analysis of the Glioblastoma MGMT Promoter by BSAS and Its Clinical Significance Open
Objective In glioblastoma (GBM), methylation of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter is a critical predictive biomarker for temozolomide (TMZ) therapy. Conventional qualitative assessment by methylation-specific …
View article: MUC1 promoter methylation pattern diversity and its association with TET3 expression and prognosis in cholangiocarcinoma
MUC1 promoter methylation pattern diversity and its association with TET3 expression and prognosis in cholangiocarcinoma Open
Cholangiocarcinoma (CC) is a highly lethal malignancy that urgently requires reliable prognostic biomarkers. Although MUC1 expression and promoter methylation have been implicated in CC, the clinical significance of promoter methylation pa…
View article: Single‑center retrospective study of factors associated with early discontinuation of tumor‑treating fields therapy in glioblastoma
Single‑center retrospective study of factors associated with early discontinuation of tumor‑treating fields therapy in glioblastoma Open
Glioblastoma (GBM) is the most aggressive primary malignant tumor of the adult central nervous system with poor survival outcomes despite multimodal standard treatment. Tumor-treating fields (TTFields) therapy prolongs survival in patients…
View article: Effects of Krüppel-like factor 4 mutation on the clinicopathological characteristics and its related protein expressions in intraductal papillary mucinous neoplasm of the pancreas
Effects of Krüppel-like factor 4 mutation on the clinicopathological characteristics and its related protein expressions in intraductal papillary mucinous neoplasm of the pancreas Open
KLF4 mutations might enhance p21 expression, possibly influencing the indolent characteristics of non-invasive IPMNs and providing a new biomarker strategy for risk stratification in patients with IPMNs.
View article: Association between intra-tumoral microbiome and genetic alterations in intraductal papillary mucinous neoplasms of the pancreas
Association between intra-tumoral microbiome and genetic alterations in intraductal papillary mucinous neoplasms of the pancreas Open
This study suggest that the intratumoral microbiome may be linked to the genetic characteristics of IPMNs and potentially contribute to their malignant progression.
View article: Pulmonary metastasis of chondrosarcoma diagnosed by transbronchial lung biopsy after differentiation from organizing pneumonia: A case report
Pulmonary metastasis of chondrosarcoma diagnosed by transbronchial lung biopsy after differentiation from organizing pneumonia: A case report Open
A 49-year-old woman presented with abdominal distention and right leg numbness. Bone biopsy from a huge tumor in her pelvis revealed chondrosarcoma, and proton beam therapy was performed. Although there were no abnormalities at 6 months, d…
View article: Urothelial carcinoma arising in orthotopic ileal neobladder reconstruction: A case report
Urothelial carcinoma arising in orthotopic ileal neobladder reconstruction: A case report Open
BACKGROUND An ileal neobladder is a standardized form of urinary diversion that provides acceptable outcomes in terms of long-term quality of life. Urothelial carcinomas (UCs) arising in the ileal neobladder are extremely rare, and few rep…
View article: Potential biomarkers for predicting the efficacy of a pembrolizumab-containing regimen in advanced cervical cancer: A real-world analysis
Potential biomarkers for predicting the efficacy of a pembrolizumab-containing regimen in advanced cervical cancer: A real-world analysis Open
CPS and TPS showed a modest correlation with progression-free survival and NLR prior to immunotherapy demonstrated the best treatment efficacy for advanced cervical cancer.
View article: Methotrexate Enhances Atherosclerosis Progression <i>via</i> Impairment of Folate Pathway in a Microminipig Model
Methotrexate Enhances Atherosclerosis Progression <i>via</i> Impairment of Folate Pathway in a Microminipig Model Open
MTX exacerbated HFHCD-induced atherosclerosis mediated through reduced blood FA and the subsequent increase of Hcy in μMPs, indicating that the μMP model may advance cardio-oncology research by providing useful experimental approaches. As …
View article: Electroporation Induces Unexpected Alterations in Gene Expression: A Tip for Selection of Optimal Transfection Method
Electroporation Induces Unexpected Alterations in Gene Expression: A Tip for Selection of Optimal Transfection Method Open
Electroporation is an efficient method for nucleotide and protein transfer, and is used for clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein 9 (Cas9)-mediated genome editing. In this study, we investigat…
View article: Comparison of actionable alterations in cancers with kinase fusion, mutation, and copy number alteration
Comparison of actionable alterations in cancers with kinase fusion, mutation, and copy number alteration Open
Kinase-related gene fusion and point mutations play pivotal roles as drivers in cancer, necessitating optimized, targeted therapy against these alterations. The efficacy of molecularly targeted therapeutics varies depending on the specific…
View article: A potential inflammatory biomarker for advanced endometrial cancer treated with lenvatinib plus pembrolizumab
A potential inflammatory biomarker for advanced endometrial cancer treated with lenvatinib plus pembrolizumab Open
Introduction To identify prognostic biomarkers that could predict how well patients will respond to lenvatinib/pembrolizumab (LEN/PEM). The utility of certain inflammatory biomarkers in endometrial liquid‐based cytology (LBC) or peripheral…
View article: 10195- MPC-19 CURRENT STATUS OF MULTICENTER STUDIES USING GLIOMA TAILORED CUSTOM DNA/RNA PANELS
10195- MPC-19 CURRENT STATUS OF MULTICENTER STUDIES USING GLIOMA TAILORED CUSTOM DNA/RNA PANELS Open
INTRODUCTION In 2018, we developed a glioma specific next-generation sequencing NGS panel and analyzed over 500 cases. In April 2023, we have expanded our work to include a custom DNA/RNA panel capable of detecting fusion genes. A multicen…
View article: 10002- MPC-1 HISTOLOGICAL GRADE AND TP53 MUTATIONS STRATIFY PROGNOSIS IN MOLECULAR GLIOBLASTOMA
10002- MPC-1 HISTOLOGICAL GRADE AND TP53 MUTATIONS STRATIFY PROGNOSIS IN MOLECULAR GLIOBLASTOMA Open
BACKGROUND In the 2021 WHO Central Nervous System tumor classification, the Glioblastoma, IDH-wildtype diagnosis has changed markedly. We compared the clinical backgrounds and prognoses of molecular glioblastoma (mGBM) and conventional gli…
View article: Malignant peripheral nerve sheath tumor of the cervix in an adolescent with neurofibromatosis type 1: A case report and review of literature
Malignant peripheral nerve sheath tumor of the cervix in an adolescent with neurofibromatosis type 1: A case report and review of literature Open
Malignant peripheral nerve sheath tumors (MPNSTs) of the cervix are rare, particularly in patients with neurofibromatosis type 1 (NF1). This report describes a cervical MPNST in an 18‐year‐old patient with no history of sexual activity, ab…
View article: Prognosis prediction via histological evaluation of cellular heterogeneity in glioblastoma
Prognosis prediction via histological evaluation of cellular heterogeneity in glioblastoma Open
Glioblastomas (GBMs) are the most aggressive types of central nervous system tumors. Although certain genomic alterations have been identified as prognostic biomarkers of GBMs, the histomorphological features that predict their prognosis r…
View article: All-in-one bimodal DNA and RNA next-generation sequencing panel for integrative diagnosis of glioma
All-in-one bimodal DNA and RNA next-generation sequencing panel for integrative diagnosis of glioma Open
Previously, we constructed a DNA-based next-generation sequencing (NGS) panel for an integrated diagnosis of gliomas according to the 2021 World Health Organization classification system. The aim of the current study was to evaluate the fe…
View article: Comparison of actionable alterations in cancers with kinase fusion, mutation, and amplification
Comparison of actionable alterations in cancers with kinase fusion, mutation, and amplification Open
Kinase-related gene fusion and point mutations play pivotal roles as drivers in cancer, necessitating optimized targeted therapy against these alterations. The efficacy of molecularly targeted therapeutics varies depending on the specific …
View article: Issue Information
Issue Information Open
Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have f…
View article: Issue Information
Issue Information Open
Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have f…
View article: Exercise Suppresses Head and Neck Squamous Cell Carcinoma Growth via Oncostatin M
Exercise Suppresses Head and Neck Squamous Cell Carcinoma Growth via Oncostatin M Open
Major advances have been made in cancer treatment, but the prognosis for elderly cancer patients with sarcopenia and frailty remains poor. Myokines, which are thought to exert preventive effects against sarcopenia, have been reported to be…
View article: Issue Information
Issue Information Open
Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have f…
View article: Issue Information
Issue Information Open
Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have f…
View article: Cervical Cytology Preserves Histologically Detected Surface Epithelial Slackening, Unique to the <i>POLE</i> Mutation-subtype in Endometrial Cancer
Cervical Cytology Preserves Histologically Detected Surface Epithelial Slackening, Unique to the <i>POLE</i> Mutation-subtype in Endometrial Cancer Open
Histologically-detected SES as well as other endometrial cancer features may be preserved in the atypical cell clusters observed in cervical cytology specimens. Cytological detection of SES and of smaller clusters of atypical cells and inf…
View article: Development of a Microminipig Model of Atherosclerosis for the Evaluation of a HMGCR Inhibitor
Development of a Microminipig Model of Atherosclerosis for the Evaluation of a HMGCR Inhibitor Open
A microminipig atherosclerosis model induced by HFLCD can be used in the evaluation of HMGCR inhibitors for the treatment of hypercholesterolemia and atherosclerosis.
View article: Case Report: The leopard sign as a potential characteristic of chronic granulomatous disease-associated colitis, unrelated to colitis severity
Case Report: The leopard sign as a potential characteristic of chronic granulomatous disease-associated colitis, unrelated to colitis severity Open
Background Chronic granulomatous disease (CGD) is an inborn immune disorder in which the phagocytic system cannot eradicate pathogens, and autoinflammation occurs. Approximately half of the patients have associated gastrointestinal symptom…
View article: Differentiating primary central nervous system lymphoma from glioblastoma by time-dependent diffusion using oscillating gradient
Differentiating primary central nervous system lymphoma from glioblastoma by time-dependent diffusion using oscillating gradient Open
Background This study aimed to elucidate the impact of effective diffusion time setting on apparent diffusion coefficient (ADC)-based differentiation between primary central nervous system lymphomas (PCNSLs) and glioblastomas (GBMs) and to…
View article: Pilocytic Astrocytoma Presenting with Spontaneous Cerebellar Hemorrhage: A Case Report
Pilocytic Astrocytoma Presenting with Spontaneous Cerebellar Hemorrhage: A Case Report Open
Hemorrhagic pilocytic astrocytomas (PAs) are rare, accounting for 1.1%-8.0% of all PA cases. They are reported to occur more frequently in older populations, with a male predominance. In this study, we report a case of a 14-year-old boy wh…
View article: Relationship between Delayed Breast Cancer Diagnosis and Behavioral Economic Factors and Personality Characteristics
Relationship between Delayed Breast Cancer Diagnosis and Behavioral Economic Factors and Personality Characteristics Open
Low time preference rate is a characteristic of patients with breast cancer who had a delayed diagnosis.