M. Á. Toro
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View article: Maintenance of genetic diversity in subdivided populations using genomic coancestry matrices
Maintenance of genetic diversity in subdivided populations using genomic coancestry matrices Open
For both undivided and subdivided populations, the consensus method to maintain genetic diversity is the Optimal Contribution (OC) method. For subdivided populations, this method determines the optimal contribution of each candidate to eac…
View article: A comparison of marker-based estimators of inbreeding and inbreeding depression
A comparison of marker-based estimators of inbreeding and inbreeding depression Open
Background The availability of genome-wide marker data allows estimation of inbreeding coefficients ( F , the probability of identity-by-descent, IBD) and, in turn, estimation of the rate of inbreeding depression (ΔID). We investigated, by…
View article: Putative Degradation of Non-Stored Sperm in the Female Reproductive Tract of the Dengue Vector Mosquito Aedes aegypti
Putative Degradation of Non-Stored Sperm in the Female Reproductive Tract of the Dengue Vector Mosquito Aedes aegypti Open
In insect vectors of disease, male and female molecules that mediate reproductive processes are promising targets to suppress fertility of these populations. One process, the storage of sperm in the female reproductive tract, is essential …
View article: Changes in Allele Frequencies When Different Genomic Coancestry Matrices Are Used for Maintaining Genetic Diversity
Changes in Allele Frequencies When Different Genomic Coancestry Matrices Are Used for Maintaining Genetic Diversity Open
A main objective in conservation programs is to maintain genetic variability. This can be achieved using the Optimal Contributions (OC) method that optimizes the contributions of candidates to the next generation by minimizing the global c…
View article: Emerging issues in genomic selection
Emerging issues in genomic selection Open
Genomic selection (GS) is now practiced successfully across many species. However, many questions remain, such as long-term effects, estimations of genomic parameters, robustness of genome-wide association study (GWAS) with small and large…
View article: The concept of effective population size loses its meaning in the context of optimal management of diversity using molecular markers
The concept of effective population size loses its meaning in the context of optimal management of diversity using molecular markers Open
Effective population size is a key parameter in conservation genetics. In the management of conservation programs using pedigree information, there is a consensus that the optimal method for maximizing effective population size is to calcu…
View article: Imperfect Linkage Disequilibrium Generates Phantom Epistasis (& Perils of Big Data)
Imperfect Linkage Disequilibrium Generates Phantom Epistasis (& Perils of Big Data) Open
The genetic architecture of complex human traits and diseases is affected by large number of possibly interacting genes, but detecting epistatic interactions can be challenging. In the last decade, several studies have alluded to problems …
View article: Imperfect Linkage Disequilibrium Generates Phantom Epistasis (& Perils of Big Data)
Imperfect Linkage Disequilibrium Generates Phantom Epistasis (& Perils of Big Data) Open
The genetic architecture of complex human traits and diseases is affected by large number of possibly interacting genes, but detecting epistatic interactions can be challenging. In the last decade, several studies have alluded to problems …
View article: Some intriguing questions on Fisher's ideas about dominance
Some intriguing questions on Fisher's ideas about dominance Open
The basic hypothesis held by Fisher (1930, The Genetical Theory of Natural Selection. Clarendon Press, Oxford) on evolution was that a large panmictic population would offer the best chance for advantageous genes to spread through a popula…
View article: Non-additive Effects in Genomic Selection
Non-additive Effects in Genomic Selection Open
In the last decade, genomic selection has become a standard in the genetic evaluation of livestock populations. However, most procedures for the implementation of genomic selection only consider the additive effects associated with SNP (Si…
View article: 216 Genomic regions and pathways associated with resistance to gastrointestinal parasites in tropical sheep breed
216 Genomic regions and pathways associated with resistance to gastrointestinal parasites in tropical sheep breed Open
The aim of this study was to estimate variance components and to identify genomic regions and pathways associated with resistance to gastrointestinal parasites, particularly Haemonchus contortus, in Santa Inês sheep, a Brazilian breed adap…
View article: Orthogonal Estimates of Variances for Additive, Dominance, and Epistatic Effects in Populations
Orthogonal Estimates of Variances for Additive, Dominance, and Epistatic Effects in Populations Open
Genomic prediction methods based on multiple markers have potential to include nonadditive effects in prediction and analysis of complex traits. However, most developments assume a Hardy–Weinberg equilibrium (HWE). Statistical approaches f…
View article: Feed efficiency of Rainbow trout (<i>Onchorynchus mykiss</i>) kept at high and low stocking density
Feed efficiency of Rainbow trout (<i>Onchorynchus mykiss</i>) kept at high and low stocking density Open
Feed efficiency is a trait of high economic importance in fish production, and is highly related to feeding regimes employed and stocking density. However, feed efficiency is difficult to estimate because measurements of individual feed in…
View article: Accuracy of genomic within‐family selection in aquaculture breeding programmes
Accuracy of genomic within‐family selection in aquaculture breeding programmes Open
Summary In aquaculture breeding programmes, selection within families cannot be applied for traits that cannot be recorded on the candidates (e.g., disease resistance or fillet quality). However, this problem can be overcome if genomic eva…
View article: Additional file 2: Table S11. of Genomic regions and pathways associated with gastrointestinal parasites resistance in Santa Inês breed adapted to tropical climate
Additional file 2: Table S11. of Genomic regions and pathways associated with gastrointestinal parasites resistance in Santa Inês breed adapted to tropical climate Open
KEGG pathways (P
View article: Additional file 1: Table S4. of Genomic regions and pathways associated with gastrointestinal parasites resistance in Santa Inês breed adapted to tropical climate
Additional file 1: Table S4. of Genomic regions and pathways associated with gastrointestinal parasites resistance in Santa Inês breed adapted to tropical climate Open
Genomic regions associated with egg counts per gram of feces (EPGlog) in Santa Inês sheep; Table S5. Genomic regions associated with famacha (FAM) in Santa Inês sheep; Table S6. Genomic regions associated with blood cell count (WBC) in San…
View article: Response: Commentary: Past, present and future of epigenetics applied to livestock breeding
Response: Commentary: Past, present and future of epigenetics applied to livestock breeding Open
Following our recent Review article (González-Recio et al., 2015), we received correspondence by Steele (2016). We thank Dr. Steele for his comments, which provide a thorough review of his work on human immunology, which has persuaded him …
View article: The use of genomic information can enhance the efficiency of conservation programs
The use of genomic information can enhance the efficiency of conservation programs Open
• The development of genomic tools allows for more accurate estimates of genetic relationships between animals (genomic coancestry coefficients) than those obtained with pedigree data (pedigree-based coancestry coefficients) and thus permi…