Explanipedia

A Case of Solitary Para-Aortic Lymph Node Metastasis of Hepatocellular Carcinoma Treated with Single Resection Open

Hiromichi Yamai, Takahiro Yoshida, Jyuniti Seike, Jyunko Honda, Takanori Miyoshi , et al. · 2008

肝細胞癌の孤立性大動脈周囲リンパ節転移に対し, 切除を行い良好な経過を得た症例を経験したので報告する. 症例は60歳代の男性で, C型肝炎を経過観察中の2005年に腹部超音波検査で肝内腫瘤を指摘され当院紹介となった. CTで肝内に4cmと4.5cmの肝細胞癌を2個認め, 大動脈周囲に2.8cmの孤立性腫瘤を認めた. 大動脈周囲の孤立性腫瘤はリンパ節転移を疑ったが, 鑑別診断に難渋したため, 肝内病変の治療を先行し, 経皮的局所療法を施行した. 2月の経過観察中に大動脈周囲の…

A Case of Gastric Lipoma with Hemorrhagic Ulcer, which Grew Up during Two Years Follow Up Period Open

Hiromichi Yamai, Nobumasa Hamaguchi, Youta Yamamoto, Kazuhisa Onishi, Nobuyuki Tanida , et al. · 2007

症例は55歳の男性で, 胃集団検診での異常陰影を指摘され当院受診した. 胃内視鏡検査で胃体下部前壁に弾性軟の直径3cmの亜有茎性粘膜下腫瘍を認めた. 超音波内視鏡検査では第3層に限局する境界明瞭な高エコー像を認め, 胃脂肪腫と診断した. その後患者の受診はなかったが, 2年後, 労作時呼吸困難を自覚し当院受診した. 血液検査でヘモグロビン8.2g/dlと貧血を認めた. 胃内視鏡検査を行ったところ, 胃体下部前壁の脂肪腫が直径5cmに増大し, 先端部には凝血塊の付着を伴った潰…

A Case of Adenocarcinoma Arising from the Gastric Ectopic Pancreas Open

Takahiro Yoshida, Atsushi Umemoto, Hiromichi Yamai, Junichi Seike, Junko Honda , et al. · 2007

非常にまれな胃異所性膵から発生した腺癌の1例を報告する. 症例は64歳の男性で, 胸膜炎の経過観察中に, 胸部CTにて胃幽門部大彎側に径3.0cmの腫瘤を偶然に指摘された. 上部消化管内視鏡検査, 超音波内視鏡検査を施行したところ, 幽門前庭部になだらかな隆起性病変を認め, 筋層を主座とする粘膜下腫瘍を認めた. Retrospectiveには2年前のCTでも存在しており, 腫瘍径にほとんど変化を認めなかった. しかし, 幽門狭窄症状を来したため, 胃gastrointest…

Proteomic alteration in gastic adenocarcinomas from Japanese patients Open

Takahiro Yoshihara, Yoshito Kadota, Yoshiyuki Yoshimura, Yutaka Tatano, Naohiro Takeuchi , et al. · 2006

Antiestrogens and the Formation of DNA Damage in Rats: A Comparison Open

Sung Yeon Kim, Naomi Suzuki, Y. R. Santosh Laxmi, Atsushi Umemoto, Tomonari Matsuda , et al. · 2006

Tamoxifen (TAM) has been used as an agent for the treatment and prevention of breast cancer. However, long-term treatment of TAM in women increases the risk of developing endometrial cancer. The secondary cancer may be due to the genotoxic…

A case of early relapsed multiple lung metastases after esophagectomy successfully treated with S-1/cisplatin therapy after docetaxel/5-fluorouracil/cisplatin therapy Open

Junichi Seike, Takahiro Yoshida, Junko Honda, Takanori Miyoshi, Atsushi Umemoto , et al. · 2006

A 55-year-old-male patient underwent subtotal esophagectomy for esophageal cancer (pT1b, N0, M0, stage II) in April 2005. The patient received postoperative chemotherapy (docetaxel 40 mg/body, 5-fluorouracil 750 mg/body, cisplatin 10mg/bod…

TOC Open

K Peifer, Yoshihito Nakanishi, Shujiro Yazumi, Daisuke Ikeuchi, A Matsumoto , et al. · 2005

INDUCTION OF TP AND DPD EXPRESSION BY DOCETAXEL AND DOXIFLURIDINE (5'-DFUR) IN GASTRIC CANCER Open

Hiroshi Okitsu, Atsushi Umemoto, Junko Honda, Natsu Okitsu, Junichi Seike , et al. · 2004

Doxifluridine (5'-DFUR)が効率良く5-FUに変換されるためにはthymidine phosphorylase (TP)の発現が誘導される必要がある.進行胃癌を対象にDocetaxel (TXT)および5'-DFURによるTP・dihydropyrimidine dehydrogenase (DPD)の発現誘導を検討した.研究1 (n=11)はTXT 20mg投与前および1週後の癌および正常粘膜のTP, DPD量を測定した.研究2 (n=14)は5'-D…

TWO CASES OF A GASTROINTESTINAL STROMAL TUMOR OF THE SMALL INTESTINE WITH SEVERE MELENA Open

Natsu Okitsu, Hiroshi Okitsu, Jyunichi Seike, Jyunko Honda, Atsushi Umemoto , et al. · 2004

今回われわれは輸血を要する大量下血を呈した小腸GISTの2例を経験したので文献的考察を加え報告する.症例1は64歳,男性.ショック状態での来院時, Hb 2.1g/dlにて赤血球濃厚液20単位を輸血した. CTで右下腹部に8×6cm大の分葉状の腫瘤,肝S8に2cm大の腫瘤を認めた.肝病変の針生検ではGISTの転移であった.手術は回腸切除,播種腹膜切除,肝部分切除を行った.術後STI571を投与中で術後15カ月の現在,再発なく経過観察中である.症例2は67歳,女性. 1年前に…

A CASE REPORT OF A GIANT SPLENIC CYST IN A YOUNG WOMAN. Open

Yasuhiro Yuasa, Hiroshi Okitsu, Junko Honda, Atsushi Umemoto, Yasumasa Monden · 2003

症例は18歳,女性.主訴は腹部膨満感.既往歴に特記事項なし.平成13年, 11月に腹部正中に約5cm大の腫瘤を自覚するも放置していた.平成14年に入り急速に増大傾向認め,画像上脾嚢胞疑いにて当院産婦人科より当科紹介となった.腹部所見として,下腹部を中心に可動性のある弾性硬の巨大な腫瘤を触知した.血液一般検査に異常なく,腫瘍マーカーはCA125が44U/mlと軽度上昇を認めた.嚢胞は下極に限局し,径約14×15×7cmであった.以上より3月腹腔鏡下用手的手術(以下HALS)に…

A Case of Transverse Colon Cancer with Idiopathic Thrombocytopenic Purpura. Open

Yasuhiro Yuasa, Hiroshi Okitsu, Kou Uyama, Hisashi Matsuoka, Natsu Okitsu , et al. · 2003

症例は73歳の男性で, 主訴は下血. 既往歴として2か月前より, 肺線維症にてプレドニゾロン (以下, PSL) 5mg/日内服中であった. 下血および血液検査上著明な汎血球減少 (WBC2.5×103/mm3, Hb 5.9g/dl, 血小板1.0×103/mm3)がみられ当院内科に緊急入院した. 精査の結果, 特発性血小板減少性紫斑病 (idiopathic thrombocytopenic purpura: 以下, ITP) を合併した横行結腸癌と診断した. ステロイ…

Identification of hepatic tamoxifen–DNA adducts in mice: α-(N2-deoxyguanosinyl)tamoxifen and α-(N2-deoxyguanosinyl)tamoxifen N-oxide Open

Atsushi Umemoto, Yasumasa Monden, Masato Suwa, Yoshikazu Kanno, Masanobu Suzuki , et al. · 2000

Tamoxifen-DNA adducts detected in the liver of mice treated with tamoxifen have not yet been identified. In the present study a new type of tamoxifen-DNA adduct, four stereoisomers of alpha-(N:(2)-deoxyguanosinyl)tamoxifen N:-oxide 3'-mono…

A SUCCESSFUL COVERAGE USING INTERCOSTAL MUSCLE WITH VASCULAR PEDICLE FOR ANASTOMOTIC LEAKAGE OF INTRATHORACIC ESOPHAGOJEJUNOSTOMY AFTER A TOTAL GASTRECTOMY -REPORT OF A CASE- Open

Megumi SOGAMA, Atsushi Umemoto, Aiichiro Kajikawa, Yasumasa Monden · 1998

We successfully conducted reanastomosis and coverage using intercostal muscle with vascular pedicle for a wide raning anastomotic leakage of intrathoracic esophagojejunostomy after a total gastrectomy. As the intrathoracic pressure is nega…

A CLINICAL STUDY OF FREE JEJUNAL TRANSFER FOR ESOPHAGEAL RECONSTRUCTION Open

Hiroshi Okitsu, Katsuhiro Tanaka, Aiichirou KAJIKAWA, Hiroyuki Inoue, Hitoshi Miki , et al. · 1996

Seventee cases of free jejunal transfer for esophageal reconstruction were subjected to a study comparing for resection and reconstruction procedures, postoperative complications, and prognosis. In eight cases of carcinoma involving the ph…

A CASE REPORT OF SPONTANEOUS EXTERNAL BILIARY FISTULA OF THE GALLBLADDER WITH A CARCINOMA OF THE GALLBLADDER Open

Yoshifumi Takehisa, Aiichiro Kajikawa, Megumi Sogame, Atsushi Umemoto, Tadashi Uyama , et al. · 1995

A 72-year-old female was seen at the hospital because of a right hypochondralgia, fistula with purulent discharge, and painful mass at the right upper quadrant of the abdomen. Fistulography revealed the fistula from the gallbladder, and fi…

A CASE OF RESECTION OF SYNCHRONOUS TRIPLE CANCER OF THE ESOPHAGUS, STOMACH AND COLON Open

Shinji Kondoh, Toshikatsu Taniki, Atsushi Umemoto, Aiichiroh KAJIKAWA, Megumi Sogame , et al. · 1995

A 61-year-old man with synchronous triple cancer involving the esophagus, stomach and colon underwent attempted curative resection. Surgical resection was performed for the thoracic esophageal cancer and gastric cancer, and the colon cance…

Metabolic aspects of pyrolysis mutagens in food. Open

Sitiro Sato, Chie Negishi, Atsushi Umemoto, Takashi Sügimura · 1986

The first step in metabolic activation of mutagenic and carcinogenic heterocyclic amines has been elucidated to be N-hydroxylation by cytochrome P-448. N-Hydroxyamino compounds are further activated to form N-O-acyl derivatives that readil…

Metabolic Aspects of Pyrolysis Mutagens in Food Open

Shigeaki Sato, Chie Negishi, Atsushi Umemoto, Takashi Sügimura · 1986

The first step in metabolic activation of mutagenic and carcinogenic heterocyclic amines has been elucidated to be N-hydroxylation by cytochrome P-448. N-Hydroxyamino compounds are further activated to form N-O-acyl derivatives that readil…

Binding of orally given 2-amino-6-methyldipyrido (1,2-a:3',2'-d) imidazole, a carcinogen, to rat hemoglobin. Open

Atsushi Umemoto, Chie Negishi, Shigeaki Sato, Takashi Sügimura · 1986

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