A. V. Ryabova
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View article: The Aptamer bi-(AID-1-T) Synergizes with Radiation to Inhibit Proliferation of Human Glioma Cells
The Aptamer bi-(AID-1-T) Synergizes with Radiation to Inhibit Proliferation of Human Glioma Cells Open
Background: High-grade gliomas are treatment-resistant and prone to aggressive recurrence. Although radiation therapy is a fundamental treatment, it often fails to eradicate tumors and can enhance the migratory potential of surviving cells…
View article: Multimodal Detection of Magnetically and Fluorescently Dual-Labeled Murine Macrophages After Intravenous Administration
Multimodal Detection of Magnetically and Fluorescently Dual-Labeled Murine Macrophages After Intravenous Administration Open
A variety of cells can be applied as vectors for the targeted delivery of chemotherapeutic or gene therapeutic agents to neoplasms. Macrophages are regarded as promising candidates for cell-based therapy. Accurate assessments of the effica…
View article: Combined Photodynamic Therapy and Chemotherapy Using Local Intra-Arterial Intratumoral Administration of Chlorin e6 and Cisplatin: First Clinical Observations
Combined Photodynamic Therapy and Chemotherapy Using Local Intra-Arterial Intratumoral Administration of Chlorin e6 and Cisplatin: First Clinical Observations Open
Despite advances in cancer treatment, head and neck squamous cell carcinoma (HNSCC) remains a serious clinical problem due to tumor aggressiveness, tumor resistance to therapy, and treatment toxicity. The combination of photodynamic therap…
View article: Molecular Cloning,<i>In Silico</i>Analysis and Expression of plasma membrane-associated NAR2 Protein, SaNAR2.2, from Euhalophyte<i>Suaeda altissima</i>
Molecular Cloning,<i>In Silico</i>Analysis and Expression of plasma membrane-associated NAR2 Protein, SaNAR2.2, from Euhalophyte<i>Suaeda altissima</i> Open
Plasma membrane-associated proteins of NAR2 family are involved in the uptake of nitrate by plant roots as partners of NRT2 family proteins, which carry out high- affinity nitrate transport across membranes of plant cells. In this study, t…
View article: DIFFICULTIES AND THE POSSIBILITY OF INTRAOPERATIVE ARREST OF EROSIVE BLEEDING FROM A POSTNECROTIC PANCREATIC CYST
DIFFICULTIES AND THE POSSIBILITY OF INTRAOPERATIVE ARREST OF EROSIVE BLEEDING FROM A POSTNECROTIC PANCREATIC CYST Open
Arrosive bleeding of pancreatonecrosis is a rare, however, life-threatening condition due to the lack of a clear arteriographic localization of the source. Most bleeding occurs against the background of infected pancreatic necrosis, as wel…
View article: Simultaneous Application of Methylene Blue and Chlorin e6 Photosensitizers: Investigation on a Cell Culture
Simultaneous Application of Methylene Blue and Chlorin e6 Photosensitizers: Investigation on a Cell Culture Open
The co-accumulation of MB with chlorin e6 prevents MB reduction to a colorless leucoform, decreasing the oxygen uptake by the cells and making it possible to use simultaneously type I and II photodynamic reactions.
View article: Spectroscopic Study of Methylene Blue Interaction with Coenzymes and Its Effect on Tumor Metabolism
Spectroscopic Study of Methylene Blue Interaction with Coenzymes and Its Effect on Tumor Metabolism Open
The possibility of using MB for the tumor metabolism correction and growth rate reduction has been demonstrated, however, the time of therapy and MB concentration should be optimized to obtain more pronounced therapeutic effect.
View article: Test system customization for genotyping the BMP-2 gene 4:28632407 A/G polymorphism in aquacultured rainbow trout
Test system customization for genotyping the BMP-2 gene 4:28632407 A/G polymorphism in aquacultured rainbow trout Open
The application of genomic selection in rainbow trout breeding is becoming more feasible with the advent of recent advances in molecular genetics. However, there are significant challenges in the field of aquaculture, as genomic and marker…
View article: Unite and Conquer: Association of Two G-Quadruplex Aptamers Provides Antiproliferative and Antimigration Activity for Cells from High-Grade Glioma Patients
Unite and Conquer: Association of Two G-Quadruplex Aptamers Provides Antiproliferative and Antimigration Activity for Cells from High-Grade Glioma Patients Open
Background: High-grade gliomas remain a virtually incurable form of brain cancer. Current therapies are unable to completely eradicate the tumor, and the tumor cells that survive chemotherapy or radiation therapy often become more aggressi…
View article: GQIcombi application to subdue glioma via differentiation therapy
GQIcombi application to subdue glioma via differentiation therapy Open
Current therapy protocols fail to cure high-grade gliomas and prevent recurrence. Therefore, novel approaches need to be developed. A re-programing of glioma cell fate is an alternative attractive way to stop tumor growth. The two-step pro…
View article: Experimental modelling of heating and local field enhancement by iron oxide nanoparticles upon laser excitation
Experimental modelling of heating and local field enhancement by iron oxide nanoparticles upon laser excitation Open
Local determination of the iron oxide nanoparticles (IONPs) temperature during laser heating is important in the aspect of laser phototherapy. We have carried out theoretical modeling of local EM field enhancement and heating under the las…
View article: Application of fluorescent-tagged antiscalants for mitigation of membrane scaling by calcium carbonate and calcium phosphate in electrodialysis stack
Application of fluorescent-tagged antiscalants for mitigation of membrane scaling by calcium carbonate and calcium phosphate in electrodialysis stack Open
Wide application of electrodialysis, which is proven to be highly effective in waste waters treatment and in a broad spectrum of other technologies, is restrained by membrane fouling.The present study is dedicated to the application of flu…
View article: The use of methylene blue to control the tumor oxygenation level
The use of methylene blue to control the tumor oxygenation level Open
Administration of MB at 10 mg/kg shown to increase tumor oxygenation level, potentially leading to more effective antitumor therapy. However, at higher doses (20 mg/kg), MB may cause long-term decrease in oxygenation.
View article: The use of peripheral venous catheter in chickens
The use of peripheral venous catheter in chickens Open
Among the methods that make it possible to obtain and evaluate biochemical indicators that characterize the direction of metabolism, the state of health and the course of the pathological process in the body, the blood examination occupies…
View article: The Bi-(AID-1-T) G-Quadruplex Has a Janus Effect on Primary and Recurrent Gliomas: Anti-Proliferation and Pro-Migration
The Bi-(AID-1-T) G-Quadruplex Has a Janus Effect on Primary and Recurrent Gliomas: Anti-Proliferation and Pro-Migration Open
High-grade gliomas are considered an incurable disease. Despite all the various therapy options available, patient survival remains low, and the tumor usually returns. Tumor resistance to conventional therapy and stimulation of the migrato…
View article: NaGdF4:Yb, Er, Tm Upconversion Nanoparticles for Bioimaging in Shortwave-Infrared Range: Study of Energy Transfer Processes and Composition Optimization
NaGdF4:Yb, Er, Tm Upconversion Nanoparticles for Bioimaging in Shortwave-Infrared Range: Study of Energy Transfer Processes and Composition Optimization Open
Upconversion nanoparticles are promising for many applications. For triple-doped nanoparticles (NPs), the luminescence intensity shows a non-linear dependence on the rare-earth ion concentration, making it difficult to obtain bright phosph…
View article: Fluorescent-tagged antiscalants as a tool of homogeneous membrane scaling mitigation and inhibition mechanism investigation in electrodialysis processing of solutions prone to calcium sulfate precipitation
Fluorescent-tagged antiscalants as a tool of homogeneous membrane scaling mitigation and inhibition mechanism investigation in electrodialysis processing of solutions prone to calcium sulfate precipitation Open
The application of antiscalants (ASs) is a widely used method for scale inhibition in various water treatment technologies, being economically sound and rather simple in terms of technical implementation.However, despite its advantages, th…
View article: Molecular Cloning, Expression and Transport Activity of SaNPF6.3/SaNRT1.1, a Novel Protein of the Low-Affinity Nitrate Transporter Family from the Euhalophyte Suaeda altissima (L.) Pall.
Molecular Cloning, Expression and Transport Activity of SaNPF6.3/SaNRT1.1, a Novel Protein of the Low-Affinity Nitrate Transporter Family from the Euhalophyte Suaeda altissima (L.) Pall. Open
The SaNPF6.3 gene, a putative ortholog of the dual-affinity nitrate (NO3−) transporter gene AtNPF6.3/AtNRT1.1 from Arabidopsis thaliana, was cloned from the euhalophyte Suaeda altissima. The nitrate transporting activity of SaNPF6.3 was st…
View article: Concentrated milk model systems: quality changes during low-temperature storage All-Russian Dairy Research Institute
Concentrated milk model systems: quality changes during low-temperature storage All-Russian Dairy Research Institute Open
One of the ways to solve the problem of low storability of raw milk is the use of frozen milk concentrates. A comprehensive understanding of the impact of negative temperatures on the stability and properties of dairy systems during long-t…
View article: Spectroscopic study of methylene blue photophysical properties in biological media
Spectroscopic study of methylene blue photophysical properties in biological media Open
A spectroscopic study of the photophysical properties of methylene blue (MB) in aqueous solutions was carried out. Absorption and fluorescence spectra as well as fluorescence lifetime were recorded. The concentration dependence of the inte…
View article: Fluorescent Microscopy of Hot Spots Induced by Laser Heating of Iron Oxide Nanoparticles
Fluorescent Microscopy of Hot Spots Induced by Laser Heating of Iron Oxide Nanoparticles Open
Determination of the iron oxide nanoparticles (IONPs) local temperature during laser heating is important in the aspect of laser phototherapy. We have carried out theoretical modeling of IONPs local electromagnetic (EM) field enhancement a…
View article: Glass enamel coatings for transmission protection of equipment and pipelines in oil and fluid environments with a high content of H2S and CO2
Glass enamel coatings for transmission protection of equipment and pipelines in oil and fluid environments with a high content of H2S and CO2 Open
The main forms of corrosion in the oil and gas industry are carbon dioxide corrosion, acid corrosion and erosive corrosion. Various methods for protecting pipelines in oil and other liquid media from corrosion are considered. It has been e…
View article: Spectroscopic study of methylene blue in vivo: effects on tissue oxygenation and tumor metabolism
Spectroscopic study of methylene blue in vivo: effects on tissue oxygenation and tumor metabolism Open
Methylene blue (MB) is a promising photosensitizer (PS) for the treatment of pathological neoplasms, since it has both photodynamic activity (under laser irradiation) and redox and catalytic properties (in the absence of light). In the fra…
View article: Calcium Sulfate Crystallization in Presence of Fluorecent-Tagged Polyacrylate and Some Refinement of Scale Inhibition Mechanism
Calcium Sulfate Crystallization in Presence of Fluorecent-Tagged Polyacrylate and Some Refinement of Scale Inhibition Mechanism Open
Deposits of calcium sulfate scale on the surfaces of industrial equipment in distillation facilities, reverse osmosis desalination plants, in oil and gas industries lead to significant clogging of pipes and membranes and to a serious incre…
View article: Fluorescent-Tagged Antiscalants—The New Materials for Scale Inhibition Mechanism Studies, Antiscalant Traceability and Antiscaling Efficacy Optimization during CaCO3 and CaSO4·2H2O Scale Formation
Fluorescent-Tagged Antiscalants—The New Materials for Scale Inhibition Mechanism Studies, Antiscalant Traceability and Antiscaling Efficacy Optimization during CaCO3 and CaSO4·2H2O Scale Formation Open
Equipment scaling leads to reduced production efficiency in a wide range of industrial applications worldwide. Various antiscaling agents are currently commonly used to mitigate this problem. However, irrespective of their long and success…
View article: Detection of Changes in Macrophage Polarization as a Result of 5-Aminolevulinic Acid Photodynamic Therapy Using Fluorescence-Lifetime Imaging Microscopy
Detection of Changes in Macrophage Polarization as a Result of 5-Aminolevulinic Acid Photodynamic Therapy Using Fluorescence-Lifetime Imaging Microscopy Open
Non-invasive detection of polarized macrophages in tumors is an urgent task in terms of combined antitumor therapy. By analyzing the fluorescence lifetime of the metabolic cofactors—the reduced form of nicotinamide adenine dinucleotide (NA…
View article: Application and Visualization of Fluorescent-Tagged Antiscalants in Electrodialysis Processing of Aqueous Solutions Prone to Gypsum Scale Deposition
Application and Visualization of Fluorescent-Tagged Antiscalants in Electrodialysis Processing of Aqueous Solutions Prone to Gypsum Scale Deposition Open
Membrane scaling is a serious problem in electrodialysis. A widely used technique for controlling scale deposition in water treatment technologies is the application of antiscalants (AS). The present study reports on gypsum scale inhibitio…
View article: Phase Transitions of Sweetened Condensed Milk in Extended Storage Temperature Ranges
Phase Transitions of Sweetened Condensed Milk in Extended Storage Temperature Ranges Open
Sweetened condensed milk is a popular food in various climatic zones, including those regions where average winter temperature falls below –30°C. Such low temperatures can trigger crystallization because they disrupt the native structure o…
View article: A Case Study of Calcium Carbonate Crystallization during Reverse Osmosis Water Desalination in Presence of Novel Fluorescent-Tagged Antiscalants
A Case Study of Calcium Carbonate Crystallization during Reverse Osmosis Water Desalination in Presence of Novel Fluorescent-Tagged Antiscalants Open
Calcium carbonate scaling in reverse osmosis (RO) desalination process is studied in the presence of two novel fluorescent-tagged scale inhibitors 1,8-naphthalimide-tagged polyacrylate (PAA-F1) and 1-hydroxy-7-(6-methoxy-1,3-dioxo-1H-benzo…