Valentin A. Stonik
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View article: Anticancer activity of triterpene glycosides from the sea star Solaster pacificus
Anticancer activity of triterpene glycosides from the sea star Solaster pacificus Open
Marine triterpene glycosides are known to exhibit significant anticancer activity. We investigated pacificusoside C and cucumariosides C 1 and C 2 isolated from a sea star Solaster pacificus in prostate cancer models with varying drug resi…
View article: Anticancer activity of triterpene glycosides from the sea star Solaster pacificus
Anticancer activity of triterpene glycosides from the sea star Solaster pacificus Open
Marine triterpene glycosides are known to exhibit significant anticancer activity. We investigated pacificusoside C and cucumariosides C1 and C2 isolated from a sea star Solaster pacificus in prostate cancer models with varying drug resist…
View article: Structure Diversity and Properties of Some Bola-like Natural Products
Structure Diversity and Properties of Some Bola-like Natural Products Open
In their shapes, molecules of some bipolar metabolites resemble the so-called bola, a hunting weapon of the South American inhabitants, consisting of two heavy balls connected to each other by a long flexible cord. Herein, we discuss the s…
View article: Evaluation of the cardiotoxicity of Echinochrome A using human induced pluripotent stem cell-derived cardiac organoids
Evaluation of the cardiotoxicity of Echinochrome A using human induced pluripotent stem cell-derived cardiac organoids Open
Echinochrome A (EchA), a marine-derived natural product, has shown promise in treating cardiovascular and inflammatory diseases due to its antioxidant and anti-inflammatory properties. However, its cardiac safety remains underexplored. In …
View article: Structure of Genes Encoding Oxidosqualene Cyclases—Key Enzymes of Triterpenoid Biosynthesis from Sea Cucumber Eupentacta fraudatrix
Structure of Genes Encoding Oxidosqualene Cyclases—Key Enzymes of Triterpenoid Biosynthesis from Sea Cucumber Eupentacta fraudatrix Open
Oxidosqualene cyclases (OSCs) are enzymes responsible for converting linear triterpenes into tetracyclic ones, which are known as precursors of other important and bioactive metabolites. Two OSCs genes encoding parkeol synthase and lanosta…
View article: Structure of Genes Encoding Oxidosqualene Cyclases – Key Enzymes of Triterpenoid Biosynthesis from Sea Cucumber Eupentacta fraudatrix
Structure of Genes Encoding Oxidosqualene Cyclases – Key Enzymes of Triterpenoid Biosynthesis from Sea Cucumber Eupentacta fraudatrix Open
Oxidosqualene cyclases (OSCs), enzymes are responsible for converting linear triterpenes into teracyclic ones, which known as precursors of other important and bioactive metabolites. Two OSCs genes encoding parkeol synthase and lanostadien…
View article: Stichoposide C and Rhizochalin as Potential Aquaglyceroporin Modulators
Stichoposide C and Rhizochalin as Potential Aquaglyceroporin Modulators Open
Aquaporins (AQPs) are a family of integral membrane proteins that selectively transport water and glycerol across the cell membrane. Because AQPs are involved in a wide range of physiological functions and pathophysiological conditions, AQ…
View article: Stichoposide C and Rhizochalin as Potential Aquaglyceroporin Modulators
Stichoposide C and Rhizochalin as Potential Aquaglyceroporin Modulators Open
Aquaporins (AQPs) are a family of integral membrane proteins that selectively transport water and glycerol across the cell membrane. Because AQPs are involved in a wide range of physiological functions and pathophysiological conditions, AQ…
View article: Sulfated Polyhydroxysteroid Glycosides from the Sea of Okhotsk Starfish Henricia leviuscula spiculifera and Potential Mechanisms for Their Observed Anti-Cancer Activity against Several Types of Human Cancer Cells
Sulfated Polyhydroxysteroid Glycosides from the Sea of Okhotsk Starfish Henricia leviuscula spiculifera and Potential Mechanisms for Their Observed Anti-Cancer Activity against Several Types of Human Cancer Cells Open
Three new monosulfated polyhydroxysteroid glycosides, spiculiferosides A (1), B (2), and C (3), along with new related unsulfated monoglycoside, spiculiferoside D (4), were isolated from an ethanolic extract of the starfish Henricia levius…
View article: New Rare Triterpene Glycosides from Pacific Sun Star, Solaster pacificus, and Their Anticancer Activity
New Rare Triterpene Glycosides from Pacific Sun Star, Solaster pacificus, and Their Anticancer Activity Open
Six previously unknown triterpene glycosides, pacificusosides L–Q (1–6), and two previously known triterpene glycosides, cucumariosides B1 (7) and A5 (8), were isolated from an alcoholic extract of Pacific sun star, Solaster pacificus. The…
View article: Fucosylated Chondroitin Sulfates with Rare Disaccharide Branches from the Sea Cucumbers Psolus peronii and Holothuria nobilis: Structures and Influence on Hematopoiesis
Fucosylated Chondroitin Sulfates with Rare Disaccharide Branches from the Sea Cucumbers Psolus peronii and Holothuria nobilis: Structures and Influence on Hematopoiesis Open
Two fucosylated chondroitin sulfates were isolated from the sea cucumbers Psolus peronii and Holothuria nobilis using a conventional extraction procedure in the presence of papain, followed by anion-exchange chromatography on DEAE-Sephacel…
View article: Carbohydrate-Containing Low Molecular Weight Metabolites of Microalgae
Carbohydrate-Containing Low Molecular Weight Metabolites of Microalgae Open
Microalgae are abundant components of the biosphere rich in low molecular weight carbohydrate-containing natural products (glycoconjugates). Glycoconjugates take part in the processes of photosynthesis, provide producers with important bio…
View article: Djakonoviosides A, A1, A2, B1–B4 — Triterpene Monosulfated Tetra- and Pentaosides from the Sea Cucumber Cucumaria djakonovi: The First Finding of a Hemiketal Fragment in the Aglycones; Activity against Human Breast Cancer Cell Lines
Djakonoviosides A, A1, A2, B1–B4 — Triterpene Monosulfated Tetra- and Pentaosides from the Sea Cucumber Cucumaria djakonovi: The First Finding of a Hemiketal Fragment in the Aglycones; Activity against Human Breast Cancer Cell Lines Open
Seven new monosulfated triterpene glycosides, djakonoviosides A (1), A1 (2), A2 (3), and B1–B4 (4–7), along with three known glycosides found earlier in the other Cucumaria species, namely okhotoside A1-1, cucumarioside A0-1, and frondosid…
View article: Carbohydrate-containing Low Molecular Weight Metabolites of Microalgae
Carbohydrate-containing Low Molecular Weight Metabolites of Microalgae Open
Microalgae are abundant components of biosphere rich in low molecular weight carbohy-drate-containing natural products (glycoconjugates). Glycoconjugates take a part in processes of photosynthesis, provide producers with important biologic…
View article: A Mass Spectrometry Database for Sea Cucumber Triterpene Glycosides
A Mass Spectrometry Database for Sea Cucumber Triterpene Glycosides Open
Sea cucumber triterpene glycosides are a class of secondary metabolites that possess distinctive chemical structures and exhibit a variety of biological and pharmacological activities. The application of MS-based approaches for the study o…
View article: Supplementary Figure 1 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity
Supplementary Figure 1 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity Open
PDF file - 2MB, Treatment of HL-60 and human primary leukemia cells with STC leads to generation of ceramide through the activation of Fas, acid SMase and neutral SMase. (A) HL-60 cells were treated with STC (0.3 muM) for 2 h and were then…
View article: Supplementary Figure 6 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity
Supplementary Figure 6 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity Open
PDF file - 1.8MB, Antioxidants inhibit the activation of neutral SMase and BSO enhances the activation of neutral SMase by STC in human leukemic cells. (A to C) HL-60 and K562 cells (1 �~ 105 cells/ well) were incubated with STC in the pre…
View article: Supplementary Figure 5 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity
Supplementary Figure 5 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity Open
PDF file - 1.8MB, GSH inhibits STC-induced neutral SMase activation, but it does not inhibit activation of Fas and acid SMase by STC in human leukemic and colorectal cancer cells. (A) HL-60 cells were treated with STC (0.3 muM) for 2 h in …
View article: Supplementary Figure 1 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity
Supplementary Figure 1 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity Open
PDF file - 2MB, Treatment of HL-60 and human primary leukemia cells with STC leads to generation of ceramide through the activation of Fas, acid SMase and neutral SMase. (A) HL-60 cells were treated with STC (0.3 muM) for 2 h and were then…
View article: Supplementary Figure 4 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity
Supplementary Figure 4 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity Open
PDF file - 1MB, Depletion of GSH and production of ROS may contribute to STC-induced apoptosis in human leukemic and colorectal cancer cells. (A) HL-60, K562, HT-29, and SNU-C4 cells were treated with STC (0.3, 0.5 muM) or STC (1.0, 1.5 mu…
View article: Supplementary Figure 4 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity
Supplementary Figure 4 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity Open
PDF file - 1MB, Depletion of GSH and production of ROS may contribute to STC-induced apoptosis in human leukemic and colorectal cancer cells. (A) HL-60, K562, HT-29, and SNU-C4 cells were treated with STC (0.3, 0.5 muM) or STC (1.0, 1.5 mu…
View article: Supplementary Figure 6 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity
Supplementary Figure 6 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity Open
PDF file - 1.8MB, Antioxidants inhibit the activation of neutral SMase and BSO enhances the activation of neutral SMase by STC in human leukemic cells. (A to C) HL-60 and K562 cells (1 �~ 105 cells/ well) were incubated with STC in the pre…
View article: Supplementary Figure 5 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity
Supplementary Figure 5 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity Open
PDF file - 1.8MB, GSH inhibits STC-induced neutral SMase activation, but it does not inhibit activation of Fas and acid SMase by STC in human leukemic and colorectal cancer cells. (A) HL-60 cells were treated with STC (0.3 muM) for 2 h in …
View article: Physicochemical characterization and phase II metabolic profiling of echinochrome A, a bioactive constituent from sea urchin, and its physiologically based pharmacokinetic modeling in rats and humans
Physicochemical characterization and phase II metabolic profiling of echinochrome A, a bioactive constituent from sea urchin, and its physiologically based pharmacokinetic modeling in rats and humans Open
Echinochrome A, a natural naphthoquinone pigment found in sea urchins, is increasingly being investigated for its nutritional and therapeutic value associated with antioxidant, anticancer, antiviral, antidiabetic, and cardioprotective acti…
View article: Supplementary Figure 3 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity
Supplementary Figure 3 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity Open
PDF file - 2.3MB, Activation of acid and neutral SMase by STC is independent from activation of Fas and caspase-8. (A) HL-60 and K562 cells were incubated with STC (0.3 muM or 0.5 muM, respectively) in the presence or absence of desipramin…
View article: Data from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity
Data from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity Open
Purpose: Marine triterpene glycosides that are physiologically active natural compounds isolated from sea cucumbers (holothurians) and sponges have antifungal, cytotoxic, and antitumor activities, whose specific molecular mechanisms remain…
View article: Supplementary Figure 3 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity
Supplementary Figure 3 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity Open
PDF file - 2.3MB, Activation of acid and neutral SMase by STC is independent from activation of Fas and caspase-8. (A) HL-60 and K562 cells were incubated with STC (0.3 muM or 0.5 muM, respectively) in the presence or absence of desipramin…
View article: Supplementary Figure 2 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity
Supplementary Figure 2 from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity Open
PDF file - 2.3MB, Treatment of colorectal cancer cells with STC leads to generation of ceramide through the activation of acid SMase and neutral SMase. (A and B) CT-26 cells (1 �~ 105 cells/well) were incubated with STC in the presence or …
View article: Data from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity
Data from Stichoposide C Induces Apoptosis through the Generation of Ceramide in Leukemia and Colorectal Cancer Cells and Shows <i>In Vivo</i> Antitumor Activity Open
Purpose: Marine triterpene glycosides that are physiologically active natural compounds isolated from sea cucumbers (holothurians) and sponges have antifungal, cytotoxic, and antitumor activities, whose specific molecular mechanisms remain…