Anna Veiga
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View article: Efficacy of Stromal Vascular Fraction Treatment for Knee Osteoarthritis: A Single-Arm Experimental Trial
Efficacy of Stromal Vascular Fraction Treatment for Knee Osteoarthritis: A Single-Arm Experimental Trial Open
Background/Objectives: Knee osteoarthritis (KOA) is a common pathology characterized by impaired joint cartilage. Mesenchymal stromal cell (MSC)-based treatments, such as stromal vascular fraction (SVF), are increasingly being used for the…
View article: Traction force and mechanosensitivity mediate species-specific implantation patterns in human and mouse embryos
Traction force and mechanosensitivity mediate species-specific implantation patterns in human and mouse embryos Open
The invasion of human embryos in the uterus overcoming the maternal tissue barrier is a crucial step in embryo implantation and subsequent development. Although tissue invasion is fundamentally a mechanical process, most studies have focus…
View article: Epithelial cells provide immunocompetence to the early embryo for bacterial clearance
Epithelial cells provide immunocompetence to the early embryo for bacterial clearance Open
Early embryos are exposed to environmental perturbations that may influence their development, including bacteria. Despite lacking a proper immune system, the surface epithelium of early embryos (trophectoderm in mammals) can phagocytose d…
View article: Desterritorialização, tanatologia e mudança climática: uma leitura de Capitalismo e esquizofrenia para um mundo em ruínas
Desterritorialização, tanatologia e mudança climática: uma leitura de Capitalismo e esquizofrenia para um mundo em ruínas Open
This article seeks to mobilize the theoretical framework developed in the two volumes of Capitalism and Schizophrenia by Deleuze and Guattari in the face of the ongoing climate crisis. We aim to mobilize the conceptualization of capitalism…
View article: Efficacy of Short vs. Long Dog-Assisted Therapy Programs in Children and Adolescents with Fetal Alcohol Spectrum Disorder: A Randomized Controlled Trial
Efficacy of Short vs. Long Dog-Assisted Therapy Programs in Children and Adolescents with Fetal Alcohol Spectrum Disorder: A Randomized Controlled Trial Open
The objective of this study was to compare the efficacy of a shorter (8 sessions) and longer (16 sessions) Dog-Assisted Therapy (DAT) program for children and adolescents with Fetal Alcohol Spectrum Disorder (FASD). We evaluated the impact…
View article: Generation of the CTRL EiPS J9 mR6F-8 iPSC line derived from healthy human outgrowth blood endothelial cells (BOECs) using mRNA reprogramming methodology
Generation of the CTRL EiPS J9 mR6F-8 iPSC line derived from healthy human outgrowth blood endothelial cells (BOECs) using mRNA reprogramming methodology Open
mRNA reprogramming is a technology for generating iPSCs with high efficiency and safety. However, it is not suitable for reprogramming non-adherent cells, the primary cell type in blood. An alternative is to obtain adherent cells from bloo…
View article: Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene
Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene Open
Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a life-threatening disease caused by the abnormal production of misfolded TTR protein by liver cells, which is then released systemically. Its amyloid deposition in the heart is linke…
View article: Generation of a bank of clinical-grade, HLA homozygous iPSC lines with high coverage of the Spanish population
Generation of a bank of clinical-grade, HLA homozygous iPSC lines with high coverage of the Spanish population Open
Background: Induced Pluripotent Stem Cells (iPSC) derived cell therapies are an interesting new area in the field of regenerative medicine. One of the approaches to decrease costs of iPSC derived therapies is the use of allogenic homozygou…
View article: O-237 Metabolic classification of embryos and oocytes based on hyperspectral imaging and machine learning
O-237 Metabolic classification of embryos and oocytes based on hyperspectral imaging and machine learning Open
Study question To classify embryos according to their metabolic fingerprint with a robust, non-invasive methodology Summary answer Our Hyperspectral (HS) phasor analysis coupled to artificial intelligence simultaneously detects 6+ metaboli…
View article: MERLIN-DEFICIENT iPSCs AS AN<i>IN VITRO</i>MODEL SYSTEM FOR STUDIYNG<i>NF2</i>PATHOGENESIS
MERLIN-DEFICIENT iPSCs AS AN<i>IN VITRO</i>MODEL SYSTEM FOR STUDIYNG<i>NF2</i>PATHOGENESIS Open
NF2-related schwannomatosis is an autosomal dominant syndrome that predisposes to the development of benign tumors of the nervous system. Schwannomas, particularly bilateral vestibular schwannomas (VS), are the most characteristic features…
View article: SARS-CoV-2, fertility and assisted reproduction
SARS-CoV-2, fertility and assisted reproduction Open
BACKGROUND In 2020, SARS-CoV-2 and the COVID-19 pandemic had a huge impact on the access to and provision of ART treatments. Gradually, knowledge of the virus and its transmission has become available, allowing ART activities to resume. St…
View article: P-412 3D live-imaging reconstruction of the human embryo implantation ex vivo
P-412 3D live-imaging reconstruction of the human embryo implantation ex vivo Open
Study question How do human embryos implant in physiological conditions and develop beyond blastocyst stage? Summary answer Human embryos apply forces during invasion of the matrix, the mural trophectoderm undergoes a quick compaction lead…
View article: O-053 ART treatment and pregnancy during covid 19 pandemia: what we learned
O-053 ART treatment and pregnancy during covid 19 pandemia: what we learned Open
In 2020, SARS-CoV-2 and the COVID-19 pandemic had a huge impact on the access to and provision of ART treatments. Gradually, knowledge about the virus and its transmission has become available and has allowed ART activities to resume with …
View article: Public Cord Blood Banks as a source of starting material for clinical grade HLA-homozygous induced pluripotent stem cells.
Public Cord Blood Banks as a source of starting material for clinical grade HLA-homozygous induced pluripotent stem cells. Open
Background: The increasing number of clinical trials for induced pluripotent stem cell (iPSC)-derived cell therapy products makes the production on clinical grade iPSC more and more relevant and necessary. Cord blood banks (CBB) are an ide…
View article: ESHRE certification of ART centres for good laboratory and clinical practice
ESHRE certification of ART centres for good laboratory and clinical practice Open
STUDY QUESTION Three years after the start of the ESHRE ART Centre Certification (ARTCC) programme, what is the current state of the system, in terms of the interest expressed in it and experiences during the assessment of ART services? SU…
View article: Stromal vascular fraction therapy for knee osteoarthritis: a systematic review
Stromal vascular fraction therapy for knee osteoarthritis: a systematic review Open
Background: Regenerative cell therapies, such as adipose-derived stromal vascular fraction (SVF), have been postulated as potential treatments for knee osteoarthritis (KOA). Objectives: To assess the efficacy and safety of SVF treatment ag…
View article: Transplantation of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium in a Swine Model of Geographic Atrophy
Transplantation of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium in a Swine Model of Geographic Atrophy Open
Background: The aim of this study was to test the feasibility and safety of subretinal transplantation of human induced pluripotent stem cell (hiPSC)-derived retinal pigment epithelium (RPE) cells into the healthy margins and within areas …
View article: Multi-ocular Organoids from Human iPS Cells Displayed Retina, Cornea, and RPE Lineages
Multi-ocular Organoids from Human iPS Cells Displayed Retina, Cornea, and RPE Lineages Open
Background: The mammalian eye is a complex organ, comprising different highly specialized tissues derived from various cell linages, including neural ectoderm, surface ectoderm, neural crest and the periocular mesenchyme. Great efforts hav…
View article: Outcomes of SARS-CoV-2 infected pregnancies after medically assisted reproduction
Outcomes of SARS-CoV-2 infected pregnancies after medically assisted reproduction Open
STUDY QUESTION What is the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the outcome of a pregnancy after medically assisted reproduction (MAR)? SUMMARY ANSWER Our results suggest that MAR pregnancies …
View article: Repopulation of decellularized retinas with hiPSC-derived retinal pigment epithelial and ocular progenitor cells shows cell engraftment, organization and differentiation
Repopulation of decellularized retinas with hiPSC-derived retinal pigment epithelial and ocular progenitor cells shows cell engraftment, organization and differentiation Open
The retinal extracellular matrix (ECM) provides architectural support, adhesion and signal guidance that controls retinal development. Decellularization of the ECM affords great potential to tissue engineering; however, how structural reti…
View article: Joint IFFS/ESHRE statement on COVID-19 vaccination for pregnant women and those considering pregnancy
Joint IFFS/ESHRE statement on COVID-19 vaccination for pregnant women and those considering pregnancy Open
Over the course of 1 year, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2: COVID-19) infection increased to more than 103 million cases with more than 2.2 million deaths reported worldwide by February 1, 20211. While increasin…
View article: Additional file 4 of Evaluation of the Spanish population coverage of a prospective HLA haplobank of induced pluripotent stem cells
Additional file 4 of Evaluation of the Spanish population coverage of a prospective HLA haplobank of induced pluripotent stem cells Open
Additional file 4.