Alberto Villani
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View article: Whole-Genome Sequencing of Adenovirus Genotypes and Clinical Implications in Pediatric Patients
Whole-Genome Sequencing of Adenovirus Genotypes and Clinical Implications in Pediatric Patients Open
Human adenoviruses (HAdV) comprise more than 100 genotypes with species-specific differences in tropism and immune response and can cause severe infections in immunocompromised patients. This study aimed to characterise the HAdV species in…
View article: Antibody response after pneumococcal vaccination in a large cohort of Italian children and adolescents with Down syndrome
Antibody response after pneumococcal vaccination in a large cohort of Italian children and adolescents with Down syndrome Open
Introduction: Pneumococcal vaccination has significantly decreased the burden of invasive pneumococcal disease in the general population, however studies on effectiveness in Down syndrome (DS) are heterogeneous. In this cross-sectional stu…
View article: When Conventional Methods Fail: First Detection of a <i>Candida viswanathii</i> Outbreak in Europe in a Paediatric Hospital Revealed by Whole Genome Sequencing and FT-IR Spectroscopy
When Conventional Methods Fail: First Detection of a <i>Candida viswanathii</i> Outbreak in Europe in a Paediatric Hospital Revealed by Whole Genome Sequencing and FT-IR Spectroscopy Open
Objectives Candida viswanathii has been sporadically reported in Asia and South America but never in Europe. This study reports the first European outbreak of C. viswanathii in a paediatric hospital, outlining diagnostic challenges and con…
View article: Clinical manifestations and severity of COVID-19 caused by Omicron among paediatric patients aged 0–17 years in Italy
Clinical manifestations and severity of COVID-19 caused by Omicron among paediatric patients aged 0–17 years in Italy Open
View article: Point-of-care lung ultrasound to differentiate bacterial and viral lower respiratory tract infections in pediatric age: a multicenter prospective observational study
Point-of-care lung ultrasound to differentiate bacterial and viral lower respiratory tract infections in pediatric age: a multicenter prospective observational study Open
View article: Viral Burden of Respiratory Syncytial Virus and Viral Coinfections as Factors Regulating Paediatric Disease Severity
Viral Burden of Respiratory Syncytial Virus and Viral Coinfections as Factors Regulating Paediatric Disease Severity Open
Background: Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infections (ARIs) in children. However, the clinical impact of RSV co-infection with other respiratory viruses remains unclear. This study investigates t…
View article: The protective role of steroids on coronary arteries in the acute phase of Kawasaki disease for high risk patients: a retrospective study
The protective role of steroids on coronary arteries in the acute phase of Kawasaki disease for high risk patients: a retrospective study Open
Purpose The incidence of coronary artery aneurysms in Kawasaki disease has been increasing for reasons that remain unclear. Recently the use of corticosteroids in KD has been reconsidered for high-risk patients. To evaluate their effective…
View article: Factors Predicting Readmission to the Emergency Department After a Diagnosis of Acute Respiratory Infection: A Two-year Experience at a Pediatric Tertiary Care Hospital in Italy
Factors Predicting Readmission to the Emergency Department After a Diagnosis of Acute Respiratory Infection: A Two-year Experience at a Pediatric Tertiary Care Hospital in Italy Open
Background: Acute respiratory infections (ARI) are among the leading causes of pediatric emergency department (ED) visits. The rate of unplanned returns to pediatric ED is an important quality indicator, and it is associated with factors s…
View article: A core curriculum for pediatric lung ultrasound: an expert consensus
A core curriculum for pediatric lung ultrasound: an expert consensus Open
The proposed core curriculum offers a structured educational platform to promote the systematic acquisition of lung ultrasound skills among pediatricians. Addressing the identified barriers is essential for the successful integration of lu…
View article: Lifestyle Intervention Improves Metabolic Dysfunction-Associated Steatotic Liver Disease in Children with Down Syndrome
Lifestyle Intervention Improves Metabolic Dysfunction-Associated Steatotic Liver Disease in Children with Down Syndrome Open
Background/Objectives: We evaluated the efficacy of a good lifestyle intervention on the severity of metabolic dysfunction-associated steatotic liver disease (MASLD) in children with Down syndrome (DS). Methods: This retrospective longitud…
View article: Parvovirus B19 Rebound
Parvovirus B19 Rebound Open
Human parvovirus B19 (B19V) is responsible for a wide clinical spectrum ranging from asymptomatic infection, through mild disease, up to life‐threatening one. Outbreaks are registered every 3–4 years, and a recent international alert for a…
View article: Strategies to increase influenza vaccination coverage in the Italian pediatric population: a literature review and expert opinion
Strategies to increase influenza vaccination coverage in the Italian pediatric population: a literature review and expert opinion Open
School-based interventions should be deeply implemented in Italy by offering a cost-effective and safe approach to vaccination and successfully overcoming socio-economic and cultural challenges. Scheduled educational programs and instituti…
View article: Severe Outcomes From Suspected Human Parvovirus B19 Infection in Immunocompetent Children: The Need for Timely Recognition
Severe Outcomes From Suspected Human Parvovirus B19 Infection in Immunocompetent Children: The Need for Timely Recognition Open
We reported a cluster of 13 previously healthy children who, over a short time frame, received care at a Level III Pediatric Hospital following emergency department (ED) presentations with severe outcomes from suspected human Parvovirus B1…
View article: Effect of Early Administration of Clarithromycin or Azithromycin on Symptoms of Pertussis in Infants
Effect of Early Administration of Clarithromycin or Azithromycin on Symptoms of Pertussis in Infants Open
Background: A resurgence of pertussis has been observed in several geographic areas in the post-COVID-19 era. Macrolides are the first-choice antibiotics for the treatment of pertussis. Limited data exist on the impact of the early adminis…
View article: An Evaluation of a Syndromic Molecular Panel in Optimising the Microbiological Diagnosis and Antimicrobial Therapy of Suspected Osteoarticular Infections in Paediatric Patients
An Evaluation of a Syndromic Molecular Panel in Optimising the Microbiological Diagnosis and Antimicrobial Therapy of Suspected Osteoarticular Infections in Paediatric Patients Open
Background/Objectives: Paediatric osteoarticular infections (POAIs) present unique diagnostic and therapeutic challenges. Microbiological culture (MC) is typically time-consuming and lacks sensitivity, especially when patients have receive…
View article: Antibiotic treatment of acute and recurrent otitis media in children: an Italian intersociety Consensus
Antibiotic treatment of acute and recurrent otitis media in children: an Italian intersociety Consensus Open
Acute Otitis Media (AOM) typically affects previously healthy children and can be recurrent. This inter-society consensus aims to provide evidence-based recommendations for the antibiotic therapy of mild, severe and recurrent otitis media …
View article: Multicenter Retrospective Analysis of 702 Pediatric Cases of Bone and Joint Infections: Definition of Clinical and Biological Features to Discriminate K. kingae, S. aureus, and Other Bacterial Infections
Multicenter Retrospective Analysis of 702 Pediatric Cases of Bone and Joint Infections: Definition of Clinical and Biological Features to Discriminate K. kingae, S. aureus, and Other Bacterial Infections Open
This study aimed to identify key differences between K. kingae infections and those caused by S. aureus or other pathogens. Differentiating these infections is crucial due to their nonspecific clinical presentations and overlapping laborat…
View article: A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease
A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease Open
View article: Predisposing Potential Risk Factors for Severe Anorexia Nervosa in Adolescents
Predisposing Potential Risk Factors for Severe Anorexia Nervosa in Adolescents Open
Background: Anorexia nervosa is a serious eating disorder that mainly affects children and adolescents. Most patients present with extreme body dissatisfaction and an obsessive focus on body weight and food. Anorexia nervosa is a complex a…
View article: Integrating Diagnostic Approaches in Infant Bacterial Meningitis Caused by a Non-K1 Escherichia coli: A Case Report
Integrating Diagnostic Approaches in Infant Bacterial Meningitis Caused by a Non-K1 Escherichia coli: A Case Report Open
Background: Infant meningitis, particularly caused by Escherichia coli, remains a life-threatening condition, especially in premature and low-weight infants. Infections of the central nervous system can be fatal, necessitating prompt diagn…
View article: High‐flow nasal cannulas versus standard oxygen therapy for moderate bronchiolitis: a quasi‐experimental analysis
High‐flow nasal cannulas versus standard oxygen therapy for moderate bronchiolitis: a quasi‐experimental analysis Open
Background In the last decades none of the medical therapies investigated have shown clear efficacy in the treatment of bronchiolitis, and literature agrees on a general de‐implementation of pharmacological therapies, recognizing an effect…
View article: Helmet Continuous Positive Airway Pressure for Acute Bronchiolitis Respiratory Failure in a Pediatric Ward: Is It a Replicable Experience?
Helmet Continuous Positive Airway Pressure for Acute Bronchiolitis Respiratory Failure in a Pediatric Ward: Is It a Replicable Experience? Open
(1) Background: Helmet Continuous Positive Airway Pressure (H-CPAP) has primarily been used in intensive care settings to treat moderate-to-severe bronchiolitis in infants. We aim to report on the feasibility of H-CPAP for selected infants…
View article: Multi-modal immune dynamics of pre-COVID-19 Kawasaki Disease following intravenous immunoglobulin
Multi-modal immune dynamics of pre-COVID-19 Kawasaki Disease following intravenous immunoglobulin Open
View article: Use of Lung Ultrasound in Cystic Fibrosis: Is It a Valuable Tool?
Use of Lung Ultrasound in Cystic Fibrosis: Is It a Valuable Tool? Open
Cystic fibrosis (CF) is a multisystem disorder characterized by progressive respiratory deterioration, significantly impacting both quality of life and survival. Over the years, lung ultrasound (LUS) has emerged as a promising tool in pedi…
View article: First Evidence of Streptococcus pyogenes M1UK Clone in Pediatric Invasive Infections in Italy by Molecular Surveillance
First Evidence of Streptococcus pyogenes M1UK Clone in Pediatric Invasive Infections in Italy by Molecular Surveillance Open
Invasive group A streptococci infections are increasing worldwide, mainly due to the emm1 lineage M1 UK emergence. Although this variant has recently been described in adult Italian patients, its circulation in children has not yet been es…
View article: Mapping and ranking outcomes for the evaluation of seasonal influenza vaccine efficacy and effectiveness: a delphi study
Mapping and ranking outcomes for the evaluation of seasonal influenza vaccine efficacy and effectiveness: a delphi study Open
Rather than focusing on laboratory-confirmed infection per se, experimental and observational VE studies should include more severe influenza-related outcomes because they are expected to exercise a greater impact on decision-making.
View article: Pediatric ultrasound practice in Italy: an exploratory survey
Pediatric ultrasound practice in Italy: an exploratory survey Open
View article: Impact of SARS‐CoV‐2 Pandemic on Emergency Hospitalizations for Acute Respiratory Infections: The Experience of a Paediatric Tertiary Care Hospital in Italy
Impact of SARS‐CoV‐2 Pandemic on Emergency Hospitalizations for Acute Respiratory Infections: The Experience of a Paediatric Tertiary Care Hospital in Italy Open
Background Acute respiratory infections (ARIs) are a major healthcare issue in children. The SARS‐CoV‐2 pandemic changed the epidemiology of ARIs; the aims of this study are to characterize the epidemiological trend of ARI emergency hospit…
View article: Whooping Cough Cases Increase in Central Italy after COVID-19 Pandemic
Whooping Cough Cases Increase in Central Italy after COVID-19 Pandemic Open
Pertussis continues to be a highly contagious respiratory infection, especially in children, with cyclical peaks of disease spread every three to five years. Here, we report relevant cases of B. pertussis infection between August 2023 and …
View article: Online Minimization of the Robot Silhouette Viewed From Eye-to-Hand Camera
Online Minimization of the Robot Silhouette Viewed From Eye-to-Hand Camera Open
Redundant robots have the potential to perform internal joints motion without modifying the pose of the end-effector by exploiting the null-space of the Jacobian matrix. Capitalizing on that feature, we developed a control technique for mi…