Vinitha Jacob
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View article: Dabigatran prevents lipopolysaccharide mediated apoptosis in zebrafish through a thrombin independent mechanism
Dabigatran prevents lipopolysaccharide mediated apoptosis in zebrafish through a thrombin independent mechanism Open
Endotoxemia is a feature of sepsis pathogenesis and has also been found to mediate the pathophysiology of multiple inflammatory conditions. In this work, we use a lipopolysaccharide (LPS) induced endotoxemia model in zebrafish to identify …
View article: Multiomic molecular patterns of lipid dysregulation in a subphenotype of sepsis with higher shock incidence and mortality
Multiomic molecular patterns of lipid dysregulation in a subphenotype of sepsis with higher shock incidence and mortality Open
Background Lipids play a critical role in defense against sepsis. We sought to investigate gene expression and lipidomic patterns of lipid dysregulation in sepsis. Methods Data from four adult sepsis studies were analyzed and findings were…
View article: DHCR7 Expression Predicts Poor Outcomes and Mortality From Sepsis
DHCR7 Expression Predicts Poor Outcomes and Mortality From Sepsis Open
IMPORTANCE: This is a study of lipid metabolic gene expression patterns to discover precision medicine for sepsis. OBJECTIVES: Sepsis patients experience poor outcomes including chronic critical illness (CCI) or early death (within 14 d). …
View article: DHCR7 Expression Predicts Poor Outcomes and Mortality from Sepsis
DHCR7 Expression Predicts Poor Outcomes and Mortality from Sepsis Open
Objective: Sepsis patients experience poor outcomes including chronic critical illness (CCI) or early death (within 14 days). We investigated lipid metabolic gene expression differences by outcome to discover therapeutic targets. Design: S…
View article: The diagnosis and management of Paget-Schroetter syndrome (primary effort thrombosis) in the emergency department
The diagnosis and management of Paget-Schroetter syndrome (primary effort thrombosis) in the emergency department Open
Introduction: Paget-Schroetter syndrome, also known as primary effort thrombosis, is a subtype of deep venous thrombosis in the subclavian vein at the costoclavicular junction. If recognized and treated appropriately, this condition has fe…
View article: The Decline of Basic Science Publications in Major Emergency Medicine Journals and Research Conferences
The Decline of Basic Science Publications in Major Emergency Medicine Journals and Research Conferences Open
A recent publication reported on the decline of basic science publications in major medical journals in the past 20 years, making reference to the growing disconnect between basic science and clinical medicine.1 Story Landis, former direct…
View article: Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling
Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling Open
Complex cytoplasmic nucleotide-sensing mechanisms can recognize foreign DNA based on a lack of methylation and initiate an immune response to clear the infection. Zebrafish embryos with global DNA hypomethylation caused by mutations in the…