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View article: Mutagenesis and functional analysis of the varicella-zoster virus portal protein
Mutagenesis and functional analysis of the varicella-zoster virus portal protein Open
Herpesviruses replicate by cleaving concatemeric dsDNA into single genomic units that are packaged through an oligomeric portal present in preformed procapsids. In contrast to what is known about phage portal proteins, details concerning h…
View article: Abstract 3791: Understanding the function of LMP1 CTAR3 in EBV-associated cancers
Abstract 3791: Understanding the function of LMP1 CTAR3 in EBV-associated cancers Open
Background: Over 90% of the human population is infected with Epstein-Barr virus (EBV), which has been linked to cancers such as Hodgkin's lymphoma and nasopharyngeal carcinoma. The principal oncoprotein responsible for cellular proliferat…
View article: Intermolecular Complementation between Two Varicella-Zoster Virus pORF30 Terminase Domains Essential for DNA Encapsidation
Intermolecular Complementation between Two Varicella-Zoster Virus pORF30 Terminase Domains Essential for DNA Encapsidation Open
The herpesviral terminase complex is part of the intricate machinery that delivers a single viral genome into empty preformed capsids (encapsidation). The varicella-zoster virus (VZV) terminase components (pORF25, pORF30, and pORF45/42) ha…