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View article: Dapagliflozin treatment ameliorates oxidative stress, apoptosis and inflammation in tenofovir-induced nephrotoxicity in rats
Dapagliflozin treatment ameliorates oxidative stress, apoptosis and inflammation in tenofovir-induced nephrotoxicity in rats Open
Tenofovir disoproxil fumarate is a widely prescribed component in antiretroviral therapy regimes frequently associated with nephrotoxicity. Dapagliflozin, an SGLT2 inhibitor, is primarily used as a hypoglycemic agent but is increasingly re…
View article: Hypovitaminosis D Does Not Aggravate the Progression of Gentamicin-Induced Kidney Injury in Rats
Hypovitaminosis D Does Not Aggravate the Progression of Gentamicin-Induced Kidney Injury in Rats Open
Background/Objectives: Gentamicin is one of the most effective and widely used antibiotics to treat serious infections. In addition to its bactericidal properties, gentamicin has a nephrotoxic effect that results in acute kidney injury (AK…
View article: Canagliflozin prevents acute kidney Injury in euglycemics rats
Canagliflozin prevents acute kidney Injury in euglycemics rats Open
Introduction: The aim of this study was to investigate the impact of canagliflozin on AKI caused by ischemia-reperfusion injury (IRI) in non-diabetic rats. Methods: Male Wistar rats weighing 250-300g were randomized into four groups: SHAM …
View article: The anti-inflammatory properties of green tea extract protect against gentamicin-induced kidney injury
The anti-inflammatory properties of green tea extract protect against gentamicin-induced kidney injury Open
We assessed in vivo the protective effects and underlying antioxidant and anti-inflammatory properties of dry green tee extract (GTE) on glomerular and tubular kidney function and structure in an experimental model of gentamicin (GEN)-indu…
View article: Amazonia Phytotherapy Reduces Ischemia and Reperfusion Injury in the Kidneys
Amazonia Phytotherapy Reduces Ischemia and Reperfusion Injury in the Kidneys Open
Acute kidney injury (AKI) is defined as a sudden decrease in kidney function. Phytomedicines have shown positive effects in the treatment of AKI worldwide. The aim of this study was to evaluate the effect of Abuta grandifolia on the renal …
View article: Administration of a single dose of lithium ameliorates rhabdomyolysis-associated acute kidney injury in rats
Administration of a single dose of lithium ameliorates rhabdomyolysis-associated acute kidney injury in rats Open
Rhabdomyolysis is characterized by muscle damage and leads to acute kidney injury (AKI). Clinical and experimental studies suggest that glycogen synthase kinase 3β (GSK3β) inhibition protects against AKI basically through its critical role…
View article: The association between obesity and vitamin D deficiency modifies the progression of kidney disease after ischemia/reperfusion injury
The association between obesity and vitamin D deficiency modifies the progression of kidney disease after ischemia/reperfusion injury Open
Acute kidney injury (AKI) alters renal hemodynamics, leading to tubular injury, activating pathways of inflammation, proliferation, and cell death. The initial damage caused to renal tissue after an ischemia/reperfusion (I/R) injury exerts…
View article: Treatment with β-blocker nebivolol ameliorates oxidative stress and endothelial dysfunction in tenofovir-induced nephrotoxicity in rats
Treatment with β-blocker nebivolol ameliorates oxidative stress and endothelial dysfunction in tenofovir-induced nephrotoxicity in rats Open
Background Tenofovir disoproxil fumarate (TDF), a widely prescribed component in antiretroviral regimens, has been associated with nephrotoxicity. Nebivolol is a third generation selective β-1 adrenergic receptor blocker and may protect re…
View article: Renoprotective effect of N-acetylcysteine depends upon the severity of the ischemia reperfusion injury
Renoprotective effect of N-acetylcysteine depends upon the severity of the ischemia reperfusion injury Open
Acute kidney injury (AKI) is a common complication in seriously ill patients, while renal ischemia-reperfusion (I/R) injury is the most frequent event in this oxidative renal injury. N-acetylcysteine (NAC) is a small molecule containing a …
View article: The Restoration of Vitamin D Levels Slows the Progression of Renal Ischemic Injury in Rats Previously Deficient in Vitamin D
The Restoration of Vitamin D Levels Slows the Progression of Renal Ischemic Injury in Rats Previously Deficient in Vitamin D Open
Chronic kidney disease (CKD) remains a global public health problem. The initial damage after ischemia/reperfusion (I/R) injury plays an important role in the pathogenesis of acute kidney injury (AKI) and predisposition to CKD. Several stu…
View article: The Blockade of TACE-Dependent EGF Receptor Activation by Losartan-Erlotinib Combination Attenuates Renal Fibrosis Formation in 5/6-Nephrectomized Rats Under Vitamin D Deficiency
The Blockade of TACE-Dependent EGF Receptor Activation by Losartan-Erlotinib Combination Attenuates Renal Fibrosis Formation in 5/6-Nephrectomized Rats Under Vitamin D Deficiency Open
Chronic kidney disease (CKD) has been considered a major public health issue. In addition to cardiovascular diseases and infections, hypovitaminosis D has been considered a non-traditional aggravating factor for CKD progression. Interstiti…
View article: Cathelicidin protects mice from Rhabdomyolysis-induced Acute Kidney Injury
Cathelicidin protects mice from Rhabdomyolysis-induced Acute Kidney Injury Open
Background: Cathelicidins are ancient and well-conserved antimicrobial peptides (AMPs) with intriguing immunomodulatory properties in both infectious and non-infectious inflammatory diseases. In addition to direct antimicrobial activity, c…
View article: Renoprotective effect of N-acetylcysteine depends upon the severity of the ischemia reperfusion injury
Renoprotective effect of N-acetylcysteine depends upon the severity of the ischemia reperfusion injury Open
Acute kidney injury (AKI) is a common complication in seriously ill patients, while renal ischemia-reperfusion (I/R) injury is the most frequent event in this oxidative renal injury. N-acetylcysteine (NAC) is a small molecule containing a …
View article: Gut Microbiota and Intestinal Epithelial Myd88 Signaling Are Crucial for Renal Injury in UUO Mice
Gut Microbiota and Intestinal Epithelial Myd88 Signaling Are Crucial for Renal Injury in UUO Mice Open
Increasing evidence shows the essential participation of gut microbiota in human health and diseases by shaping local and systemic immunity. Despite an accumulating body of studies showing that chronic kidney disease (CKD) is closely assoc…
View article: Pathogenic role of innate immunity in a model of chronic NO inhibition associated with salt overload
Pathogenic role of innate immunity in a model of chronic NO inhibition associated with salt overload Open
Nitric oxide inhibition with N ω -nitro-l-arginine methyl ester (l-NAME), along with salt overload, leads to hypertension, albuminuria, glomerulosclerosis, glomerular ischemia, and interstitial fibrosis, characterizing a chronic kidney dis…
View article: Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic‐ and GPR109a‐mediated mechanisms
Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic‐ and GPR109a‐mediated mechanisms Open
Butyrate is a short‐chain fatty acid derived from the metabolism of indigestible carbohydrates by the gut microbiota. Butyrate contributes to gut homeostasis, but it may also control inflammatory responses and host physiology in other tiss…
View article: Vitamin D deficiency is a potential risk factor for lipid Amphotericin B nephrotoxicity
Vitamin D deficiency is a potential risk factor for lipid Amphotericin B nephrotoxicity Open
Invasive fungal infections (IFI) is a worldwide serious health problem and Amphotericin B (AmB) has been considered the drug of choice for IFI treatment. Despite its efficacy, clinical use of AmB has been associated with renal toxicity. So…
View article: Preventive effect of exercise training on diabetic kidney disease in ovariectomized rats with type 1 diabetes
Preventive effect of exercise training on diabetic kidney disease in ovariectomized rats with type 1 diabetes Open
This study evaluated the effects of moderate regular physical exercise on lipid peroxidation, inflammation and renal function and structure in streptozotocin (STZ)-induced ovariectomized diabetic rats. Twenty-four Wistar rats were anesthet…
View article: Th17/Treg imbalance in COPD progression: A temporal analysis using a CS-induced model
Th17/Treg imbalance in COPD progression: A temporal analysis using a CS-induced model Open
Our results showed that the microenvironmental stimuli produced by the release of cytokines during COPD progression lead to a Th17/Treg imbalance.
View article: Vitamin D Deficiency Aggravates the Renal Features of Moderate Chronic Kidney Disease in 5/6 Nephrectomized Rats
Vitamin D Deficiency Aggravates the Renal Features of Moderate Chronic Kidney Disease in 5/6 Nephrectomized Rats Open
The pathogenesis of chronic kidney disease (CKD) involves a very complex interaction between hemodynamic and inflammatory processes, leading to glomerular/vascular sclerosis, and fibrosis formation with subsequent evolution to end-stage of…
View article: Simultaneous activation of innate and adaptive immunity participates in the development of renal injury in a model of heavy proteinuria
Simultaneous activation of innate and adaptive immunity participates in the development of renal injury in a model of heavy proteinuria Open
Protein overload of proximal tubular cells (PTCs) can promote interstitial injury by unclear mechanisms that may involve activation of innate immunity. We investigated whether prolonged exposure of tubular cells to high protein concentrati…
View article: Previous Exercise Training Reduces Markers of Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Female Rats
Previous Exercise Training Reduces Markers of Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Female Rats Open
The aim of this study is to evaluate the effects of regular moderate exercise training initiated previously or after induction of diabetes mellitus on renal oxidative stress and inflammation in STZ-induced diabetic female rats. For this pu…
View article: Allopurinol attenuates acute kidney injury following Bothrops jararaca envenomation
Allopurinol attenuates acute kidney injury following Bothrops jararaca envenomation Open
Snakebites have been recognized as a neglected public health problem in several tropical and subtropical countries. Bothrops snakebites frequently complicate with acute kidney injury (AKI) with relevant morbidity and mortality. To date, th…
View article: Human umbilical cord-derived mesenchymal stromal cells protect against premature renal senescence resulting from oxidative stress in rats with acute kidney injury
Human umbilical cord-derived mesenchymal stromal cells protect against premature renal senescence resulting from oxidative stress in rats with acute kidney injury Open
Our data demonstrate that huMSCs attenuate the inflammatory and oxidative stress responses occurring in AKI, as well as reducing the expression of senescence-related proteins and microRNAs. Our findings broaden perspectives for the treatme…
View article: The Role of β-Adrenergic Overstimulation in the Early Stages of Renal Injury
The Role of β-Adrenergic Overstimulation in the Early Stages of Renal Injury Open
Background/Aims: To assess the possible contribution of the β-adrenergic overstimulation in early stages of renal injury, the present study evaluated, in rats, the effects of the β-adrenoceptor agonist isoproterenol (ISO) on renal function…
View article: Maternal Hypercholesterolemia Associated with Nicotine Exposure in Adulthood May Induce Kidney Injury in Male Rats if Hypomagnesemia Occurs
Maternal Hypercholesterolemia Associated with Nicotine Exposure in Adulthood May Induce Kidney Injury in Male Rats if Hypomagnesemia Occurs Open
Background/Aims: Maternal hypercholesterolemia is a risk factor to renal injury in rat pups at adulthood, especially if they feed a cholesterol-enriched diet after weaning. However, the renal function of male pups of dams with hypercholest…
View article: N-acetylcysteine protects against star fruit-induced acute kidney injury
N-acetylcysteine protects against star fruit-induced acute kidney injury Open
Our data show that therapeutic NAC attenuates renal dysfunction in a model of acute oxalate nephropathy following SF ingestion by reducing oxidative stress, oxaluria, and inflammation. This might represent a novel indication of NAC for the…
View article: Vasopressin analog terlipressin attenuates kidney injury in hemorrhagic shock
Vasopressin analog terlipressin attenuates kidney injury in hemorrhagic shock Open
Background In hemorrhagic shock (HS), volume replacement with crystalloid solution can restore the hemodynamic status and decrease mortality. However, it can also lead to tissue edema and pulmonary congestion, as well as increasing vascula…
View article: Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring
Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring Open
The influence of sleep restriction (SR) during pregnancy on blood pressure and renal function among female adult offspring was investigated. Pregnant Wistar rats were distributed into control and SR groups. The SR was performed between the…