Ava Kwong
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View article: Does Yoga Therapy Improve Range of Motion in Shoulders of Women Recovering from Breast Cancer Surgery? A Randomised Controlled Trial
Does Yoga Therapy Improve Range of Motion in Shoulders of Women Recovering from Breast Cancer Surgery? A Randomised Controlled Trial Open
HKU Clinical Trials Registry, HKUCTR-1600. Registered 25 May 2013, https://www.hkuctr.com/Study/Show/36d8e3e8d051473b9c2e69bc8ee35dd1 .
View article: Overextended Messengers: Insights Into the Government Public Health Communications Workforce From the 2024 PH WINS
Overextended Messengers: Insights Into the Government Public Health Communications Workforce From the 2024 PH WINS Open
Amid escalating public health challenges, the communications workforce plays a vital but under-resourced role in government public health. Using 2024 Public Health Workforce Interests and Needs Survey data, we provide the first national pr…
View article: Threshold-Based Overlap of Breast Cancer High-Risk Classification Using Family History, Polygenic Risk Scores, and Traditional Risk Models in 180,398 Women
Threshold-Based Overlap of Breast Cancer High-Risk Classification Using Family History, Polygenic Risk Scores, and Traditional Risk Models in 180,398 Women Open
Background: Breast cancer polygenic risk scores (PRS) and traditional risk models (e.g., the Gail model [Gail]) are known to contribute largely independent information, but it is unclear how the overlap varies by ancestry, age, disease typ…
View article: Polygenic risk score for breast cancer risk prediction in Asian BRCA1 and BRCA2 pathogenic variants carriers
Polygenic risk score for breast cancer risk prediction in Asian BRCA1 and BRCA2 pathogenic variants carriers Open
Polygenic risk scores (PRS) have been shown to be predictive of breast cancer (BC) risk in European BRCA1 and BRCA2 pathogenic variant (PV) carriers, but their utility in Asian populations has not been evaluated. In this study, we evaluate…
View article: ConquerFear-HK: A Randomized Controlled Trial of a Metacognition-Based, Manualized Intervention for Fear of Cancer Recurrence among Chinese Cancer Survivors
ConquerFear-HK: A Randomized Controlled Trial of a Metacognition-Based, Manualized Intervention for Fear of Cancer Recurrence among Chinese Cancer Survivors Open
Introduction: Fear of cancer recurrence (FCR) is a prominent clinical issue among cancer survivors. This study evaluated the effectiveness of the culturally adapted ConquerFear-HK intervention in reducing FCR among Chinese cancer survivors…
View article: Germline BARD1 Mutation in High-Risk Chinese Breast and Ovarian Cancer Patients
Germline BARD1 Mutation in High-Risk Chinese Breast and Ovarian Cancer Patients Open
Background: The prevalence of BARD1 mutations in breast and ovarian cancers varies across different ethnic groups. Evaluating the cancer risk and clinical significance of BARD1 mutations in the local Chinese patients with breast cancer, ov…
View article: Massively parallel immunopeptidome by DNA sequencing provides insights into cancer antigen presentation
Massively parallel immunopeptidome by DNA sequencing provides insights into cancer antigen presentation Open
Human leukocyte antigens (HLAs) are encoded by the most polymorphic genes in the human genome. HLA class I alleles control antigen presentation for T cell recognition, which is pivotal for autoimmunity, infectious diseases and cancer. Curr…
View article: Different strategies in de-escalation of axillary surgery in node-positive breast cancer following neoadjuvant treatment: a systematic review and meta-analysis of long-term outcomes
Different strategies in de-escalation of axillary surgery in node-positive breast cancer following neoadjuvant treatment: a systematic review and meta-analysis of long-term outcomes Open
Purpose Different surgical options existed in the management of axilla among breast cancer patients who were initially node-positive and were converted node-negative after neoadjuvant systemic treatment (NST). De-escalation of axillary sur…
View article: How do the preferences of older Chinese women with operable breast cancer differ from their younger counterparts?
How do the preferences of older Chinese women with operable breast cancer differ from their younger counterparts? Open
Introduction This study aims to investigate how the preferences of older women are different from their young counterparts. Methods Female patients with operable breast cancer diagnosed between September 2009 and August 2015 were recruited…
View article: Overlap of high-risk individuals across family history, genetic & non-genetic breast cancer risk models: Analysis of 180,398 women from European & Asian ancestries
Overlap of high-risk individuals across family history, genetic & non-genetic breast cancer risk models: Analysis of 180,398 women from European & Asian ancestries Open
Background Breast cancer is multifactorial. Focusing on limited risk factors may miss high-risk individuals. Methods We assessed the performance and overlap of various risk factors in identifying high-risk individuals for invasive breast c…
View article: Adipogenesis biomarkers as the independent predictive factors for breast cancer recurrence: a systematic review and meta-analysis
Adipogenesis biomarkers as the independent predictive factors for breast cancer recurrence: a systematic review and meta-analysis Open
Background Comprehensive analysis of clinical evidence for breast cancer adipogenesis with prognosis is lacking. This study aims to consolidate the latest evidence on the relationship between adipogenesis and breast cancer outcomes. Data s…
View article: Results from the randomized KEYNOTE-355 study of pembrolizumab plus chemotherapy for Asian patients with advanced TNBC
Results from the randomized KEYNOTE-355 study of pembrolizumab plus chemotherapy for Asian patients with advanced TNBC Open
In the phase 3 KEYNOTE-355 study (NCT02819518), pembrolizumab plus chemotherapy demonstrated statistically significant and clinically meaningful improvements in progression-free survival (PFS) and overall survival (OS) versus placebo plus …
View article: Mutation Spectrum Comparison between Benign Breast Lesion Cohort, Unselected Cancer Cohort and High-Risk Breast Cancer Cohort
Mutation Spectrum Comparison between Benign Breast Lesion Cohort, Unselected Cancer Cohort and High-Risk Breast Cancer Cohort Open
Mutation study for high-risk breast and ovarian cancer (HBOC) has been extensively studied in patients of different ethnicities. Here we compared the germline mutation rate and mutation spectrum of patients (n = 4341) with benign breast di…
View article: Clinical Application of Large Language Models for Breast Conditions: A Systematic Review
Clinical Application of Large Language Models for Breast Conditions: A Systematic Review Open
Background The application of artificial intelligence (AI) like Large Language Models (LLM) into the healthcare system has been a frequently discussed topic in recent years. Materials and Methods We conducted a systemic review on primary s…
View article: Germline RAD51C and RAD51D Mutations in High-Risk Chinese Breast and/or Ovarian Cancer Patients and Families
Germline RAD51C and RAD51D Mutations in High-Risk Chinese Breast and/or Ovarian Cancer Patients and Families Open
Background: RAD51C and RAD51D are crucial in homologous recombination (HR) DNA repair. The prevalence of the RAD51C and RAD51D mutations in breast cancer varies across ethnic groups. Associations of RAD51C and RAD51D germline pathogenic va…
View article: Cost-effectiveness of Pembrolizumab in Combination with Chemotherapy as Neoadjuvant Treatment and Continued as a Single Agent Adjuvant Treatment for High-Risk Early-Stage Triple-Negative Breast Cancer in Hong Kong
Cost-effectiveness of Pembrolizumab in Combination with Chemotherapy as Neoadjuvant Treatment and Continued as a Single Agent Adjuvant Treatment for High-Risk Early-Stage Triple-Negative Breast Cancer in Hong Kong Open
On the basis of the analysis conducted for a 56-year-old cohort with high-risk eTNBC and assumptions in the model, pembrolizumab + chemotherapy represents a cost-effective proposition (as the ICER is approximately 35% of the GDP per capita…
View article: Double Heterozygosity for Germline Mutations in Chinese Breast Cancer Patients
Double Heterozygosity for Germline Mutations in Chinese Breast Cancer Patients Open
Double pathogenic mutations occurring in an individual are considered a rare event. The introduction of a multiple-gene panel at Hong Kong Hereditary Breast Cancer Family Registry has allowed the identification of pathogenic variants in mu…
View article: Current practices and challenges in genetic testing and counseling for women with breast and ovarian cancer in Asia
Current practices and challenges in genetic testing and counseling for women with breast and ovarian cancer in Asia Open
Aim This study assesses current practices and challenges in genetic testing and counseling (GT and C) for breast cancer gene ( BRCA )1/2 mutations in Asia, considering the increased risk of ovarian cancer (OC) and breast cancer (BC) in wom…
View article: Evolution of localization methods for non-palpable breast lesions: a literature review from a translational medicine perspective
Evolution of localization methods for non-palpable breast lesions: a literature review from a translational medicine perspective Open
The evolution of breast lesion localization methods has progressed to more patient-friendly techniques, each with its unique advantages and limitations. Future research on patient-reported outcomes, cosmetic outcomes, breast biopsy markers…
View article: Comparison of clinical characteristics between ACOSOG Z0011–eligible cohort and sentinel lymph node–positive breast cancer patients in Hong Kong
Comparison of clinical characteristics between ACOSOG Z0011–eligible cohort and sentinel lymph node–positive breast cancer patients in Hong Kong Open
This study demonstrated that clinicopathological features were comparable between SLN-positive breast cancer patients undergoing mastectomy and those undergoing breast-conserving treatment. Low-risk SLN-positive mastectomy patients may saf…