A. Yu. Polushin
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View article: LINE-1 methylation status in multiple sclerosis patients is associated with changes in folate metabolism
LINE-1 methylation status in multiple sclerosis patients is associated with changes in folate metabolism Open
The disruption of epigenetic regulation and the development of abnormal DNA methylation patterns are crucial steps in the pathogenesis of neurodegenerative diseases. Methylation alterations in multiple sclerosis (MS) patients may contribut…
View article: Wernicke encephalopathy in the bone marrow transplantation clinic: diagnostic and therapeutic aspects for hematologists, neurologists, nutritionists
Wernicke encephalopathy in the bone marrow transplantation clinic: diagnostic and therapeutic aspects for hematologists, neurologists, nutritionists Open
Introduction. Hematopoietic stem cell transplantation (HSCT) is a complex method characterized by high-dose chemotherapy exposure, a long period of pancytopenia and the use of immunosuppressants, which can cause undesirable complications, …
View article: Cardiovascular system response to intravenous administration of physiologic sodium chloride solution in healthy subjects
Cardiovascular system response to intravenous administration of physiologic sodium chloride solution in healthy subjects Open
Introduction . Infusion therapy, despite all its advantages, is not fully understood regarding its impact on the cardiovascular system when large volumes of fluid are used. Objective . To assess the response of the cardiovascular system to…
View article: LEPTOMENINGEAL METASTASES IN A REAL-LIFE SETTING OF AN ONCOLOGY CENTER – CLINICAL PRESENTATION AND NEUROIMAGING FEATURES
LEPTOMENINGEAL METASTASES IN A REAL-LIFE SETTING OF AN ONCOLOGY CENTER – CLINICAL PRESENTATION AND NEUROIMAGING FEATURES Open
neoplastic meningitis, leptomeningeal metastases, secondary leptomeningeal lesions.
View article: The successful treatment of refractory Crohn's disease by high-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation: a clinical case
The successful treatment of refractory Crohn's disease by high-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation: a clinical case Open
Despite the available novel drug treatments for inflammatory bowel diseases, the number of patients with treatment resistance has been growing. These patients might need more aggressive treatment strategies, as the lack of control over the…
View article: Resting state functional magnetic resonance imaging in patients with multiple sclerosis before and after high-dose immunosuppressive therapy and autologous hemopoietic stem cell transplantation
Resting state functional magnetic resonance imaging in patients with multiple sclerosis before and after high-dose immunosuppressive therapy and autologous hemopoietic stem cell transplantation Open
BACKGROUND: Multiple sclerosis is a chronic autoimmune disease characterized by multifocal foci of demyelination in the central nervous system, usually affecting people of working age. The disease causes damage to the blood-brain barrier, …
View article: Analysis of the quality of life in patients with multiple sclerosis within 3 years after high-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation
Analysis of the quality of life in patients with multiple sclerosis within 3 years after high-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation Open
Introduction. To date, data have been accumulated indicating the high effectiveness of the HDIT-AHSCT and the possibility of preserving and improving the quality of life of patients after its application. The objective was to analyze the d…
View article: High-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation in crohn disease: literature review
High-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation in crohn disease: literature review Open
The literature review presents the current status of the method of high-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation in the treatment of Crohn’s disease.In recent decades, there has been an increas…
View article: CNS manifestations in acute and chronic graft-versus-host disease
CNS manifestations in acute and chronic graft-versus-host disease Open
Despite the growing evidence supporting the existence of CNS involvement in acute and chronic graft-versus-host disease (CNS-GvHD), the characteristics and course of the disease are still largely unknown. In this multicentre retrospective …
View article: High-dose immunosuppressive therapy followed by haematopoietic stem cell transplantation as a method for the treatment of refractory forms of neuromyelitis optica spectrum disorder in children
High-dose immunosuppressive therapy followed by haematopoietic stem cell transplantation as a method for the treatment of refractory forms of neuromyelitis optica spectrum disorder in children Open
Neuromyelitis optica spectrum disorders (NMOSD) is a general term for immune-mediated diseases of the central nervous system whose phenotype includes affection of the optic nerve, brainstem encephalitis and myelitis. NMOSD is most commonly…
View article: Autologous hematopoietic stem cell transplantation as a method of immune prevention of type 1 diabetes mellitus: possibilities and prospects
Autologous hematopoietic stem cell transplantation as a method of immune prevention of type 1 diabetes mellitus: possibilities and prospects Open
Type 1 diabetes mellitus (DM) is one of the most common autoimmune disease that is treated with lifelong insulin therapy. Non-target indicators of glycemic control, which are observed in 71% of patients, lead to the formation and progressi…
View article: Lipoprotein(a) as a risk factor for cardiovascular diseases - focus on ischemic stroke (a position paper)
Lipoprotein(a) as a risk factor for cardiovascular diseases - focus on ischemic stroke (a position paper) Open
High lipoprotein(a) (LP(a)) level contributes as an independent risk factor to the development of cardiovascular diseases of atherosclerotic origin. The article contains data on the structural features of this particle, the genetic determi…
View article: A central vein sign in the magnetic resonance diagnosing of multiple sclerosis
A central vein sign in the magnetic resonance diagnosing of multiple sclerosis Open
Background . Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease, which is characterized by the inevitable disability of patients in the long term, which determines the relevance of this problem. Currently, active improve…
View article: Stroke before hematopoietic stem cell transplantation is a possible risk factor for post-transplant adverse outcomes
Stroke before hematopoietic stem cell transplantation is a possible risk factor for post-transplant adverse outcomes Open
More than 50,000 hematopoietic stem cell transplants (HSCT) are performed annually in the world for blood malignancies, solid tumors, aplastic anemia, primary immunodeficiency, autoimmune and metabolic diseases.Stroke occurs in 3% of patie…
View article: Quality of life of patients with multiple sclerosis after high-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation
Quality of life of patients with multiple sclerosis after high-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation Open
Introduction. Multiple sclerosis (MS) is a chronic autoimmune and neurodegenerative disease of the central nervous system (CNS). High-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation (HDIT–AHSCT) is th…
View article: Trends in Outcome of Hematopoietic Stem Cell Transplantation: 5000 Transplantations and 30 Years of Single-Center Experience
Trends in Outcome of Hematopoietic Stem Cell Transplantation: 5000 Transplantations and 30 Years of Single-Center Experience Open
In this single-center analysis, we evaluated the trends in 5185 hematopoietic cell transplantations performed between 1990 and 2022. The study group comprised 3237 allogeneic (alloHCT) and 1948 autologous (autoHCT) hematopoietic cell trans…
View article: Basal ganglia atrophy as a marker of multiple sclerosis progression
Basal ganglia atrophy as a marker of multiple sclerosis progression Open
This study presents the findings of the magnetic resonance morphometric analysis of brain subcortical structures in patients with remitting relapsing multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS) phenotypes …
View article: Mechanisms of central nervous system damage in COVID-19
Mechanisms of central nervous system damage in COVID-19 Open
The issues of diagnosis and treatment of nervous system damage in the new coronavirus infection (COVID-19) remain relevant, regardless of information and experience in treating such patients, accumulated nowadays. The review contains updat…
View article: Opsoclonus-myoclonus-ataxia syndrome as a complication of pembrolizumab treatment in an adult patient (a case report and literature review)
Opsoclonus-myoclonus-ataxia syndrome as a complication of pembrolizumab treatment in an adult patient (a case report and literature review) Open
Background. Opsoclonus-myoclonus-ataxia syndrome (OMAS) in adults is an extremely rare condition, often leading to rapidly deteriorated neurological performance. The majority of published cases are considered as being of post-infectious, p…
View article: Cerebrovascular complications of hematopoetic stem cell transplantation in patients with hematologic malignancies
Cerebrovascular complications of hematopoetic stem cell transplantation in patients with hematologic malignancies Open
Introduction. Modern transplantation and biological therapy methods are associated with a wide range of adverse events and complications. Incidence and variety of neurological complications mostly depend on myelo- and immunosuppression sev…
View article: Identification of the pathogenesis features of various phenotypes of multiple sclerosis based on the study of the morphological functional connectivity of subcortical gray matter structures
Identification of the pathogenesis features of various phenotypes of multiple sclerosis based on the study of the morphological functional connectivity of subcortical gray matter structures Open
Objective. The aim of study: to investigate the functional changes in the thalamus, amygdala, and hippocampal region using functional MRI at rest and determine their clinical significance in various types of MS. Materials and methods. 68 p…
View article: Endocrine complications in the treatment of autoimmune diseases by high-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation
Endocrine complications in the treatment of autoimmune diseases by high-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation Open
View article: Asthenia correction in a patient with acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation (case report)
Asthenia correction in a patient with acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation (case report) Open
Asthenic syndrome is one of the most common conditions in the clinical practice of medical specialists having various therapeutic spheres The genesis of asthenic disorder is diverse and can be represented by cerebrovascular pathology, meta…
View article: High-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation in multiple sclerosis: side effects and the tools of their reduction
High-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation in multiple sclerosis: side effects and the tools of their reduction Open
High-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation (HDIT-AHSCT) is a promising and effective method of treatment of autoimmune diseases, including multiple sclerosis.Over the past 20 years, the freq…
View article: High-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation in multiple sclerosis: preliminary clinical results of approbation of the method
High-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation in multiple sclerosis: preliminary clinical results of approbation of the method Open
Introduction. In 2018–2020, a study was conducted in the Russian Federation on the efficacy and safety of highdose immunosuppressive therapy with autologous hematopoietic stem cell transplantation (HDIT-AHSCT) in multiple sclerosis (MS). T…
View article: High-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation in multiple sclerosis: approaches to risk management
High-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation in multiple sclerosis: approaches to risk management Open
Introduction. High-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation (HDIT/AHSCT) is a promising and effective method for treating immune disorders, including multiple sclerosis (MS). The frequency and …
View article: Headache in bone marrow donors and oncohematological patients, who taking granulocyte colony-stimulating factor: incidence and clinical features
Headache in bone marrow donors and oncohematological patients, who taking granulocyte colony-stimulating factor: incidence and clinical features Open
The aim of the study was to assess the incidence and clinical features of headache associated with the use of granulocyte colony-stimulating factor (G-CSF) for stem cell mobilization or neutropenia treatment among oncohematological patient…
View article: Anti-MuSK myasthenia after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia
Anti-MuSK myasthenia after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia Open
Anti-MuSK myasthenia is a chronic autoimmune disease caused by violation of the function of the agrin-MuSK-Lrp4 complex, accompanied by the development of pathological muscle fatigue and often muscle atrophy. The disease can be a primary, …
View article: High-dose immunosuppressive therapy with autologous hematopoietic stem cells transplantation for multiple sclerosis: Current view
High-dose immunosuppressive therapy with autologous hematopoietic stem cells transplantation for multiple sclerosis: Current view Open
Autologous hematopoietic stem cells transplantation (aHSCT) followed by high-dose immunosuppressive therapy is a promising and effective method of treating autoimmune diseases, including multiple sclerosis (MS).Over the past 15-20 years, f…
View article: Application of Machine Learning Methods for Epilepsy Risk Ranking in Patients with Hematopoietic Malignancies Using
Application of Machine Learning Methods for Epilepsy Risk Ranking in Patients with Hematopoietic Malignancies Using Open
Machine learning methods to predict the risk of epilepsy, including vascular epilepsy, in oncohematological patients are currently considered promising. These methods are used in research to predict pharmacoresistant epilepsy and surgical …