Anke H. Maitland‐van der Zee
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View article: Pulmonary Sequelae of Severe Acute COVID‐19 and Multisystem Inflammatory Syndrome (MIS‐C) in Dutch Children
Pulmonary Sequelae of Severe Acute COVID‐19 and Multisystem Inflammatory Syndrome (MIS‐C) in Dutch Children Open
Background Although rare, COVID‐19 in children may lead to hospitalization due to severe respiratory symptoms, or a hyperinflammatory state called Multisystem Inflammatory Syndrome in Children (MIS‐C). This study examined respiratory morbi…
View article: Metagenomics approach to predict antibiotic resistance genes in sputum samples of adult people with cystic fibrosis: a pilot study
Metagenomics approach to predict antibiotic resistance genes in sputum samples of adult people with cystic fibrosis: a pilot study Open
Lung infections in people with cystic fibrosis (CF) cause lung damage, which is the leading factor in the morbidity and mortality of CF. Prescription of antibiotics to treat these infections is essential to maintain a higher quality of lif…
View article: Multidrug-resistant <i>Haemophilus influenzae</i> cluster of severe asthma from sputum bacteriome-resistome
Multidrug-resistant <i>Haemophilus influenzae</i> cluster of severe asthma from sputum bacteriome-resistome Open
Background Severe asthma encompasses heterogeneous inflammatory phenotypes and airway bacteriome diversity but the state of its airway resistome remains understudied. We therefore evaluated the link between the airway microbiome and the an…
View article: Socioeconomic inequalities in severe childhood asthma: results of a nationwide cohort
Socioeconomic inequalities in severe childhood asthma: results of a nationwide cohort Open
Objectives Emerging evidence shows that health disparities contribute to an increased risk of severe asthma. Therefore, the study objectives were to explore how socioeconomic disparities influence the risk of severe paediatric asthma in th…
View article: Maternal Smoking and CC-16: Implications for Lung Development and COPD Across the Lifespan
Maternal Smoking and CC-16: Implications for Lung Development and COPD Across the Lifespan Open
Maternal smoking was linked to reduced circulating and airway CC16 in COPD patients, controls, and a preclinical murine COPD model. In human adults, lower CC16 correlated with accelerated lung function decline and emphysema progression, wh…
View article: Impact of air pollution on COVID-19 severity: a systematic review of underlying biological mechanisms
Impact of air pollution on COVID-19 severity: a systematic review of underlying biological mechanisms Open
Background Our recent systematic review highlighted key associations between ambient air pollution (AAP) exposure and COVID-19 severity. This systematic review aims to summarise toxicological studies on the biological mechanisms underlying…
View article: Barrier dysfunction in nasal epithelium contributes to persistent inflammation in long COVID
Barrier dysfunction in nasal epithelium contributes to persistent inflammation in long COVID Open
While multiple organ systems are implicated in LC, our findings identified nasal epithelial dysfunction in a subgroup of LC patients and chronic activation as potential contributors to systemic immune dysregulation. The IL-1β-IFN-γ axis re…
View article: Measurement variability in residential PM2.5: an evaluation of a low-cost sensor in the Netherlands
Measurement variability in residential PM2.5: an evaluation of a low-cost sensor in the Netherlands Open
Accurate residential air quality assessment is crucial for studying health risks, evaluating local mitigation measures, and empowering citizens. Low-cost-sensors (LCS) have gained popularity for enhancing monitoring coverage and providing …
View article: Defining a long COVID ‘expotype’ within the P4O2 COVID-19 study
Defining a long COVID ‘expotype’ within the P4O2 COVID-19 study Open
The external exposome could be associated with fatigue severity and QoL in long COVID patients, however these associations were not found in the horseshoe model. Prevention strategies and urban planning could take these associations into a…
View article: Air pollution and long COVID: association with pulmonary function and radiological abnormalities 3–15 months post-COVID
Air pollution and long COVID: association with pulmonary function and radiological abnormalities 3–15 months post-COVID Open
While studies have examined associations between air pollution and subjective long COVID outcomes such as fatigue and symptoms, no studies have focused on objective lung health measures. This study aimed to assess the impact of air polluti…
View article: Estimated glomerular filtration rate in post COVID-19 patients at 3–6 months and 12–18 months after infection
Estimated glomerular filtration rate in post COVID-19 patients at 3–6 months and 12–18 months after infection Open
Previous COVID-19 infection was associated with a reduced eGFR up to 18 months after infection with higher age and CVD/hypertension increasing this likelihood.
View article: Complementary Predictors for Asthma Attack Prediction in Children: Salivary Microbiome, Serum Inflammatory Mediators, and Past Attack History
Complementary Predictors for Asthma Attack Prediction in Children: Salivary Microbiome, Serum Inflammatory Mediators, and Past Attack History Open
Background Early identification of children at risk of asthma attacks is important for optimizing treatment strategies. We aimed to integrate salivary microbiome and serum inflammatory mediator profiles with asthma attacks history to devel…
View article: Real‐world population pharmacokinetics of tezacaftor‐ivacaftor in children with cystic fibrosis: The SYM‐CF study
Real‐world population pharmacokinetics of tezacaftor‐ivacaftor in children with cystic fibrosis: The SYM‐CF study Open
Aims The clinical effectiveness of tezacaftor‐ivacaftor in children with cystic fibrosis (cwCF) varies; some patients respond while others do not or have adverse effects. The pharmacokinetics (PK) of tezacaftor‐ivacaftor are inadequately p…
View article: Toward precision medicine: Inflammatory nasal epithelial transcriptomic profiles in long COVID
Toward precision medicine: Inflammatory nasal epithelial transcriptomic profiles in long COVID Open
Nasal epithelium in LC exhibits persistent inflammatory states. SMURF1 upregulation potentially contributes to an exacerbated inflammatory state in nasal epithelium of patients with radiological abnormalities. This study demonstrates the i…
View article: Chromosome 21 variants tied to severe asthma exacerbations: A genome-wide association study in a Brazilian population
Chromosome 21 variants tied to severe asthma exacerbations: A genome-wide association study in a Brazilian population Open
The CXADR is highlighted as a potential novel susceptibility locus for asthma exacerbations, possibly tied to viral respiratory infections. Further replication and validation are needed.
View article: <scp> <i>ADRB2</i> </scp> genotype‐guided treatment for childhood asthma: Cost analysis of the <scp>PUFFIN</scp> and <scp>PACT</scp> trials
<span> <i>ADRB2</i> </span> genotype‐guided treatment for childhood asthma: Cost analysis of the <span>PUFFIN</span> and <span>PACT</span> trials Open
Background Long‐acting β2‐agonists (LABA) are commonly used to treat asthma. Some children do not respond well to LABA, which may be due to +46G>A−/rs1042713 (Arg16 amino acid) in the ADRB2 gene encoding the β2 receptor. Arg16Gly ADRB2 gen…
View article: Uncovering Non-Invasive Biomarkers in Paediatric Severe Acute Asthma Using Targeted Exhaled Breath Analysis
Uncovering Non-Invasive Biomarkers in Paediatric Severe Acute Asthma Using Targeted Exhaled Breath Analysis Open
Background: Severe acute asthma (SAA) in children can be life-threatening. There has been a significant rise in paediatric intensive care unit (PICU) admissions due to SAA over the past two decades. While asthma is a heterogeneous disease,…
View article: Prognostic biomarkers for the development of progressive pulmonary fibrosis in hypersensitivity pneumonitis: a systematic review
Prognostic biomarkers for the development of progressive pulmonary fibrosis in hypersensitivity pneumonitis: a systematic review Open
Background In fibrotic hypersensitivity pneumonitis (fHP) an ongoing immune response triggers pulmonary inflammation and concurrent fibrotic pathways, leading to irreversible disease progression. Patients with the progressive pulmonary fib…
View article: The Omics Landscape of Long <scp>COVID</scp>—A Comprehensive Systematic Review to Advance Biomarker, Target and Drug Discovery
The Omics Landscape of Long <span>COVID</span>—A Comprehensive Systematic Review to Advance Biomarker, Target and Drug Discovery Open
An estimated 10% of coronavirus disease (COVID‐19) survivors suffer from persisting symptoms referred to as long COVID (LC), a condition for which approved treatment options are still lacking. This systematic review (PROSPERO: CRD420244992…
View article: Real-world pharmacokinetics of elexacaftor-tezacaftor-ivacaftor in children with cystic fibrosis: a prospective observational study
Real-world pharmacokinetics of elexacaftor-tezacaftor-ivacaftor in children with cystic fibrosis: a prospective observational study Open
This study is the first analysis of ETI popPK in cwCF. The developed popPK models may be used to further study the exposure-response relationship and its variability within cwCF, as a basis for more personalized dosing.
View article: Exhaled volatile organic compounds associated with chronic obstructive pulmonary disease exacerbations—a systematic review and validation
Exhaled volatile organic compounds associated with chronic obstructive pulmonary disease exacerbations—a systematic review and validation Open
Chronic obstructive pulmonary disease (COPD) exacerbations significantly contribute to disease progression, hospitalizations, and decreased quality of life. Early detection of exacerbations through non-invasive methods, such as exhaled vol…
View article: Exploring Heterogeneity of Fecal Microbiome in Long COVID Patients at 3 to 6 Months After Infection
Exploring Heterogeneity of Fecal Microbiome in Long COVID Patients at 3 to 6 Months After Infection Open
An estimated 10% of COVID-19 survivors have been reported to suffer from complaints after at least three months. The intestinal microbiome has been shown to impact long COVID through the gut–lung axis and impact the severity. We aimed to i…
View article: Epigenome‐Wide Association Study of Asthma Exacerbations in Europeans
Epigenome‐Wide Association Study of Asthma Exacerbations in Europeans Open
Background Asthma exacerbations (AEs) represent the major contributor to the global asthma burden. Although genetic and environmental factors have been associated with AEs, the role of epigenetics remains uncovered. Objective This study ai…
View article: A data management system for precision medicine
A data management system for precision medicine Open
Precision, or personalised medicine has advanced requirements for medical data management systems (MedDMSs). MedDMS for precision medicine should be able to process hundreds of parameters from multiple sites, be adaptable while remaining i…