Ann Zeuner
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View article: The <scp>ACCEPTance</scp> of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis
The <span>ACCEPTance</span> of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis Open
Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality, with metastatic CRC (mCRC) posing significant challenges due to tumor heterogeneity and resistance to therapy. Circulating tumor cells (CTC) and circulating hybri…
View article: Detecting Very Weak Signals: A Mixed Strategy to Deal with Biologically Relevant Information
Detecting Very Weak Signals: A Mixed Strategy to Deal with Biologically Relevant Information Open
In many biological investigations, the relevant information does not coincide with the most powerful signals (most elevated eigenvalues, dominant frequencies, most populated clusters...), but very often hides in minor features that are dif…
View article: Network Analysis of miRNA and Cytokine Landscape in Human Hematopoiesis
Network Analysis of miRNA and Cytokine Landscape in Human Hematopoiesis Open
The differentiation/maturation trajectories of different blood cell types stemming from a CD34+ common ancestor takes place in different biologically relevant multidimensional spaces. Here, we generated microRNA and cytokine profiles from …
View article: Anti-Tumor Immunity to Patient-Derived Breast Cancer Cells by Vaccination with Interferon-Alpha-Conditioned Dendritic Cells (IFN-DC)
Anti-Tumor Immunity to Patient-Derived Breast Cancer Cells by Vaccination with Interferon-Alpha-Conditioned Dendritic Cells (IFN-DC) Open
Background: Breast cancer represents one of the leading causes of death among women. Surgery can be effective, but once breast cancer has metastasized, it becomes extremely difficult to treat. Conventional therapies are associated with sub…
View article: Validated LC-MS/MS Assay for the Quantitative Determination of Fenretinide in Plasma and Tumor and Its Application in a Pharmacokinetic Study in Mice of a Novel Oral Nanoformulation of Fenretinide
Validated LC-MS/MS Assay for the Quantitative Determination of Fenretinide in Plasma and Tumor and Its Application in a Pharmacokinetic Study in Mice of a Novel Oral Nanoformulation of Fenretinide Open
We describe the development and validation of a HPLC-MS/MS method to assess the pharmacokinetics and tumor distribution of fenretinide, a synthetic retinoid chemically related to all-trans-retinoic acid, after administration of a novel ora…
View article: Validated Lc-Ms/Ms Assay for the Quantitative Determination of Fenretinide in Plasma and Tumor and Its Application to Pharmacokinetic Study in Mice of a Novel Oral Nanoformulation of Fenretinide
Validated Lc-Ms/Ms Assay for the Quantitative Determination of Fenretinide in Plasma and Tumor and Its Application to Pharmacokinetic Study in Mice of a Novel Oral Nanoformulation of Fenretinide Open
We describe the development and validation of a HPLC-MS/MS method to assess the pharmacokinetics and tumour distribution of fenretinide, a synthetic retinoid chemically related to all-trans-retinoic acid, after administration of a novel or…
View article: Is cancer an intelligent species?
Is cancer an intelligent species? Open
Some relevant emerging properties of intelligent systems are “adaptation to a changing environment,” “reaction to unexpected situations,” “capacity of problem solving,” and “ability to communicate.” Single cells have remarkable abilities t…
View article: Supplementary Figure 1 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary Figure 1 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Immunophenotypic characterization of lymphoid districts populations in WT or tumor-bearing Her2/neu transgenic mice, in the presence or absence of a functional IFN-I system
View article: Supplementary Table 1 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary Table 1 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Expression of putative CSC markers in neuT vs IFNAR-neuT tumors
View article: Data from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Data from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Type I interferon (IFN-I) is a class of antiviral immunomodulatory cytokines involved in many stages of tumor initiation and progression. IFN-I acts directly on tumor cells to inhibit cell growth and indirectly by activating immune cells t…
View article: Supplementary Table 1 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary Table 1 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Expression of putative CSC markers in neuT vs IFNAR-neuT tumors
View article: Supplementary Figure 1 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary Figure 1 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Immunophenotypic characterization of lymphoid districts populations in WT or tumor-bearing Her2/neu transgenic mice, in the presence or absence of a functional IFN-I system
View article: Supplementary figures legend from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary figures legend from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Legends of supplementary figures
View article: Supplementary Figure 2 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary Figure 2 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Kaplan-Meier showing RFS analysis of breast cancer patients divided by subtype according to IFNAR-neuT overexpressed genes
View article: Supplementary Figure 3 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary Figure 3 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Tumor growth of neuT and IFNAR-neuT tumor cells transplanted subcutaneously in NSG mice
View article: Supplementary Figure 2 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary Figure 2 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Kaplan-Meier showing RFS analysis of breast cancer patients divided by subtype according to IFNAR-neuT overexpressed genes
View article: Supplementary Figure 3 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary Figure 3 from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Tumor growth of neuT and IFNAR-neuT tumor cells transplanted subcutaneously in NSG mice
View article: Data from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Data from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Type I interferon (IFN-I) is a class of antiviral immunomodulatory cytokines involved in many stages of tumor initiation and progression. IFN-I acts directly on tumor cells to inhibit cell growth and indirectly by activating immune cells t…
View article: Supplementary figures legend from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells
Supplementary figures legend from Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells Open
Legends of supplementary figures
View article: Data from Prevention of Chemotherapy-Induced Anemia and Thrombocytopenia by Constant Administration of Stem Cell Factor
Data from Prevention of Chemotherapy-Induced Anemia and Thrombocytopenia by Constant Administration of Stem Cell Factor Open
Purpose: Chemotherapy-induced apoptosis of immature hematopoietic cells is a major cause of anemia and thrombocytopenia in cancer patients. Although hematopoietic growth factors such as erythropoietin and colony-stimulating factors cannot …
View article: Supplementary Figure 1 from Prevention of Chemotherapy-Induced Anemia and Thrombocytopenia by Constant Administration of Stem Cell Factor
Supplementary Figure 1 from Prevention of Chemotherapy-Induced Anemia and Thrombocytopenia by Constant Administration of Stem Cell Factor Open
PDF file - 141KB
View article: Supplementary Figure 1 from Prevention of Chemotherapy-Induced Anemia and Thrombocytopenia by Constant Administration of Stem Cell Factor
Supplementary Figure 1 from Prevention of Chemotherapy-Induced Anemia and Thrombocytopenia by Constant Administration of Stem Cell Factor Open
PDF file - 141KB
View article: Data from Prevention of Chemotherapy-Induced Anemia and Thrombocytopenia by Constant Administration of Stem Cell Factor
Data from Prevention of Chemotherapy-Induced Anemia and Thrombocytopenia by Constant Administration of Stem Cell Factor Open
Purpose: Chemotherapy-induced apoptosis of immature hematopoietic cells is a major cause of anemia and thrombocytopenia in cancer patients. Although hematopoietic growth factors such as erythropoietin and colony-stimulating factors cannot …
View article: Supplementary Figure 2 from Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells
Supplementary Figure 2 from Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells Open
Supplementary Figure 2 from Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells
View article: Supplementary Figure 1 from Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells
Supplementary Figure 1 from Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells Open
Supplementary Figure 1 from Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells
View article: Supplementary Methods, Figure Legends 1-2 from Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells
Supplementary Methods, Figure Legends 1-2 from Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells Open
Supplementary Methods, Figure Legends 1-2 from Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells
View article: Supplementary Figure 2 from Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells
Supplementary Figure 2 from Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells Open
Supplementary Figure 2 from Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells
View article: Data from Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells
Data from Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells Open
Colorectal cancer stem cells (CR-CSC) are responsible for the generation and maintenance of intestinal tumors and are highly resistant to conventional chemotherapeutic agents. Aurora-A, a serine-threonine kinase involved in mitosis regulat…
View article: Supplementary Methods, Figure Legends 1-2 from Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells
Supplementary Methods, Figure Legends 1-2 from Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells Open
Supplementary Methods, Figure Legends 1-2 from Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells