Aad P. van den Berg
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View article: Effects of interrupting the enterohepatic circulation in amatoxin intoxications
Effects of interrupting the enterohepatic circulation in amatoxin intoxications Open
Treatment with activated charcoal in patients with amatoxin poisoning was associated with a greater chance of a successful outcome. Additionally, activated charcoal was associated with a reduction in markers of liver function, but not mark…
View article: Tacrolimus versus mycophenolate for AutoImmune hepatitis patients with incompLete response On first-line therapy (TAILOR study): a study protocol for a phase III, open-label, multicentre, randomised controlled trial
Tacrolimus versus mycophenolate for AutoImmune hepatitis patients with incompLete response On first-line therapy (TAILOR study): a study protocol for a phase III, open-label, multicentre, randomised controlled trial Open
View article: Prolonged hypothermic machine perfusion enables daytime liver transplantation – an IDEAL stage 2 prospective clinical trial
Prolonged hypothermic machine perfusion enables daytime liver transplantation – an IDEAL stage 2 prospective clinical trial Open
University Medical Center Groningen, the Netherlands.
View article: An open-label randomised-controlled trial of azathioprine vs. mycophenolate mofetil for the induction of remission in treatment-naive autoimmune hepatitis
An open-label randomised-controlled trial of azathioprine vs. mycophenolate mofetil for the induction of remission in treatment-naive autoimmune hepatitis Open
View article: Tacrolimus versus mycophenolate for autoimmune hepatitis patients with incomplete response on first line therapy (TAILOR study): a study protocol for a phase III, open-label, multicentre, randomised controlled trial
Tacrolimus versus mycophenolate for autoimmune hepatitis patients with incomplete response on first line therapy (TAILOR study): a study protocol for a phase III, open-label, multicentre, randomised controlled trial Open
• Background : Autoimmune hepatitis (AIH) is a rare, chronic inflammatory disease of the liver. Treatment goal is reaching complete biochemical response (CR), defined as normalization of aspartate and alanine aminotransferases and immunogl…
View article: Qualifying the suitability of living donor livers for pediatric liver transplantation: are we doing the right thing?
Qualifying the suitability of living donor livers for pediatric liver transplantation: are we doing the right thing? Open
View article: Health-related Quality of Life and Fatigue in Liver Transplant Recipients Receiving Tacrolimus Versus Sirolimus-based Immunosuppression: Results From a Randomized Trial
Health-related Quality of Life and Fatigue in Liver Transplant Recipients Receiving Tacrolimus Versus Sirolimus-based Immunosuppression: Results From a Randomized Trial Open
Background. The impact of different immunosuppression regimes on the health-related quality of life (HRQoL) and the severity of fatigue in liver transplant recipients is largely unknown. We investigated the impact of a sirolimus-based regi…
View article: Randomized Trial of Ciclosporin with 2-h Monitoring vs. Tacrolimus with Trough Monitoring in Liver Transplantation: DELTA Study
Randomized Trial of Ciclosporin with 2-h Monitoring vs. Tacrolimus with Trough Monitoring in Liver Transplantation: DELTA Study Open
In the first year after LT immunosuppression with T0 leads to less tBPAR and better patient-/re-transplant-free survival as compared to C2.
View article: Three-year results of renal function in liver transplant recipients on low-dose sirolimus and tacrolimus: a multicenter randomized, controlled trial
Three-year results of renal function in liver transplant recipients on low-dose sirolimus and tacrolimus: a multicenter randomized, controlled trial Open
The aim of this study was to investigate whether the combination of low-dose sirolimus (SRL) and low-dose extended-release tacrolimus (TAC) compared to normal-dose extended-release TAC results in a difference in the renal function and comp…
View article: Assessing the efficacy and safety of mycophenolate mofetil versus azathioprine in patients with autoimmune hepatitis (CAMARO trial): study protocol for a randomised controlled trial
Assessing the efficacy and safety of mycophenolate mofetil versus azathioprine in patients with autoimmune hepatitis (CAMARO trial): study protocol for a randomised controlled trial Open
Background Currently, the standard therapy for autoimmune hepatitis (AIH) consists of a combination of prednisolone and azathioprine. However, 15% of patients are intolerant to azathioprine which necessitates cessation of azathioprine or c…
View article: Amanitin intoxication: effects of therapies on clinical outcomes – a review of 40 years of reported cases
Amanitin intoxication: effects of therapies on clinical outcomes – a review of 40 years of reported cases Open
Based on data available, no statistical differences could be observed for the effects of NAC, PEN or SIL in proven poisonings with amanitin-containing mushrooms. However, monotherapy with SIL or PEN and combination therapy with NAC/SIL app…
View article: Assessing the efficacy and safety of mycophenolate mofetil versus azathioprine in patients with autoimmune hepatitis (CAMARO trial): study protocol for a randomised controlled trial
Assessing the efficacy and safety of mycophenolate mofetil versus azathioprine in patients with autoimmune hepatitis (CAMARO trial): study protocol for a randomised controlled trial Open
Background: Currently, standard therapy for autoimmune hepatitis (AIH) consists of a combination of prednisolone and azathioprine. However, 15% of patients are intolerant for azathioprine that necessitate cessation of azathioprine or chang…
View article: Waitlist mortality of young patients with biliary atresia: Impact of allocation policy and living donor liver transplantation
Waitlist mortality of young patients with biliary atresia: Impact of allocation policy and living donor liver transplantation Open
Patients with biliary atresia (BA) below 2 years of age in need of a transplantation largely rely on partial grafts from deceased donors (deceased donor liver transplantation [DDLT]) or living donors (living donor liver transplantation [LD…
View article: Calcineurin Inhibitors in the Treatment of Adult Autoimmune Hepatitis: A Systematic Review
Calcineurin Inhibitors in the Treatment of Adult Autoimmune Hepatitis: A Systematic Review Open
CNIs as rescue treatment in adult AIH patients are reasonably effective and safe both with insufficient response or intolerance to previous treatment. Prospective studies are needed.
View article: Sequential hypothermic and normothermic machine perfusion enables safe transplantation of high-risk donor livers
Sequential hypothermic and normothermic machine perfusion enables safe transplantation of high-risk donor livers Open
View article: Protocol for a randomized controlled multicenter trial assessing the efficacy of leuprorelin for severe polycystic liver disease: the AGAINST-PLD study
Protocol for a randomized controlled multicenter trial assessing the efficacy of leuprorelin for severe polycystic liver disease: the AGAINST-PLD study Open
View article: Outcomes after primary and repeat thermal ablation of hepatocellular carcinoma with or without liver transplantation
Outcomes after primary and repeat thermal ablation of hepatocellular carcinoma with or without liver transplantation Open
Objectives Thermal ablation (TA) is an established treatment for early HCC. There is a lack of data on the efficacy of repeated TA for recurrent HCC, resulting in uncertainty whether good oncologic outcomes can be obtained without performi…
View article: Prolonged dual hypothermic oxygenated machine preservation (DHOPE-PRO) in liver transplantation: study protocol for a stage 2, prospective, dual-arm, safety and feasibility clinical trial
Prolonged dual hypothermic oxygenated machine preservation (DHOPE-PRO) in liver transplantation: study protocol for a stage 2, prospective, dual-arm, safety and feasibility clinical trial Open
Introduction End-ischaemic preservation of a donor liver by dual hypothermic oxygenated machine perfusion (DHOPE) for 2 hours prior to transplantation is sufficient to mitigate ischaemia-reperfusion damage and fully restore cellular energy…
View article: Amanitin intoxication: effects of therapies on clinical outcomes – a review of 40 years of reported cases
Amanitin intoxication: effects of therapies on clinical outcomes – a review of 40 years of reported cases Open
Amanita phalloides poisoning causes severe liver damage which may be potentially fatal. Several treatments are available, but their effectiveness has not been systematically evaluated. We performed a systematic review to investigate…
View article: Development and validation of a prognostic score for long‐term transplant‐free survival in autoimmune hepatitis type 1
Development and validation of a prognostic score for long‐term transplant‐free survival in autoimmune hepatitis type 1 Open
Background No prognostic score is currently available for long‐term survival in autoimmune hepatitis (AIH) patients. Objective The aim of this study was to develop and validate such a prognostic score for AIH patients at diagnosis. Methods…
View article: Machine Perfusion of Donation After Circulatory Death Liver and Lungs Before Combined Liver-lung Transplantation
Machine Perfusion of Donation After Circulatory Death Liver and Lungs Before Combined Liver-lung Transplantation Open
Shortage of deceased donor organs for transplantation has led to the increased use of organs from donation after circulatory death (DCD) donors. There are currently no reports describing outcomes after multiorgan transplantation with DCD l…
View article: Maintenance immunosuppressive therapy in autoimmune hepatitis: To stop or not to stop, that is the question.
Maintenance immunosuppressive therapy in autoimmune hepatitis: To stop or not to stop, that is the question. Open
View article: Hypothermic Machine Perfusion in Liver Transplantation — A Randomized Trial
Hypothermic Machine Perfusion in Liver Transplantation — A Randomized Trial Open
Hypothermic oxygenated machine perfusion led to a lower risk of nonanastomotic biliary strictures following the transplantation of livers obtained from donors after circulatory death than conventional static cold storage. (Funded by Fonds …
View article: Controlled DCD Liver Transplantation Is Not Associated With Increased Hyperfibrinolysis and Blood Loss After Graft Reperfusion
Controlled DCD Liver Transplantation Is Not Associated With Increased Hyperfibrinolysis and Blood Loss After Graft Reperfusion Open
Background. The specific effect of donation after circulatory death (DCD) liver grafts on fibrinolysis, blood loss, and transfusion requirements after graft reperfusion is not well known. The aim of this study was to determine whether tran…
View article: Donor diabetes mellitus is a risk factor for diminished outcome after liver transplantation: a nationwide retrospective cohort study
Donor diabetes mellitus is a risk factor for diminished outcome after liver transplantation: a nationwide retrospective cohort study Open
With the growing incidence of diabetes mellitus (DM), an increasing number of organ donors with DM can be expected. We sought to investigate the association between donor DM with early post-transplant outcomes. From a national cohort of ad…
View article: Screening for abnormal glycosylation in a cohort of adult liver disease patients
Screening for abnormal glycosylation in a cohort of adult liver disease patients Open
Congenital disorders of glycosylation (CDG) are a rapidly expanding group of rare genetic defects in glycosylation. In a novel CDG subgroup of vacuolar‐ATPase (V‐ATPase) assembly defects, various degrees of hepatic injury have been describ…
View article: Donor hepatectomy time influences ischemia-reperfusion injury of the biliary tree in donation after circulatory death liver transplantation
Donor hepatectomy time influences ischemia-reperfusion injury of the biliary tree in donation after circulatory death liver transplantation Open
View article: Post-transplant obesity impacts long-term survival after liver transplantation
Post-transplant obesity impacts long-term survival after liver transplantation Open
View article: Selected liver grafts from donation after circulatory death can be safely used for retransplantation – a multicenter retrospective study
Selected liver grafts from donation after circulatory death can be safely used for retransplantation – a multicenter retrospective study Open
Due to the growing number of liver transplantations (LTs), there is an increasing number of patients requiring retransplantation (reLT). Data on the use of grafts from extended criteria donors (ECD), especially donation after circulatory d…
View article: Liver retransplantation in adult recipients: analysis of a 38‐year experience in the Netherlands
Liver retransplantation in adult recipients: analysis of a 38‐year experience in the Netherlands Open
Background Liver retransplantation (re‐LT) accounts for up to 22% after primary liver transplantation (LT), and using donor livers for retransplantation can only be justified by successful outcomes. Methods A total of 2,387 adult recipient…