Aakash Sheth
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View article: P450: Patterns of presentation, recurrence and propensity score matched outcome analysis of invasive lobular carcinoma- a tertiary care cancer centre experience
P450: Patterns of presentation, recurrence and propensity score matched outcome analysis of invasive lobular carcinoma- a tertiary care cancer centre experience Open
View article: Understanding MASH: An Examination of Progression and Clinical Outcomes by Disease Severity in the TARGET-NASH Database
Understanding MASH: An Examination of Progression and Clinical Outcomes by Disease Severity in the TARGET-NASH Database Open
Progression to all-cause mortality in patients with MASH was significantly associated with the presence of higher fibrosis stage and cirrhosis. Cardiometabolic comorbidities such as T2D and hypertension were prevalent in patients with MASH…
View article: Combined left atrial appendage occlusion and catheter ablation procedure for left atrial arrhythmias: A real‐world, propensity‐matched analysis
Combined left atrial appendage occlusion and catheter ablation procedure for left atrial arrhythmias: A real‐world, propensity‐matched analysis Open
Introduction Real‐world studies comparing safety and efficacy of combined percutaneous left atrial appendage occlusion (LAAO) and catheter ablation (CA) to LAAO alone are limited. Methods Patients from a large US hospital system undergoing…
View article: PO-05-188 TRENDS OF CARDIOVASCULAR MORTALITY IN PATIENTS WITH ATRIAL FIBRILLATION AND CANCER IN THE UNITED STATES FROM 1999-2000
PO-05-188 TRENDS OF CARDIOVASCULAR MORTALITY IN PATIENTS WITH ATRIAL FIBRILLATION AND CANCER IN THE UNITED STATES FROM 1999-2000 Open
View article: Supplementary Data from p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade
Supplementary Data from p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade Open
Supplementary Data from p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade
View article: Supplementary Data from p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade
Supplementary Data from p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade Open
Supplementary Data from p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade
View article: Supplementary Data from p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade
Supplementary Data from p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade Open
Supplementary Data from p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade
View article: Supplementary Data from p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade
Supplementary Data from p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade Open
Supplementary Data from p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade
View article: Data from p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade
Data from p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade Open
Squamous cell carcinoma driven by human papillomavirus (HPV) is more sensitive to DNA-damaging therapies than its HPV-negative counterpart. Here, we show that p16, the clinically used surrogate for HPV positivity, renders cells more sensit…
View article: Data from p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade
Data from p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade Open
Squamous cell carcinoma driven by human papillomavirus (HPV) is more sensitive to DNA-damaging therapies than its HPV-negative counterpart. Here, we show that p16, the clinically used surrogate for HPV positivity, renders cells more sensit…
View article: Impact of Gender on Outcomes of Transcatheter edge to edge mitral valve repair: A Meta-analysis.
Impact of Gender on Outcomes of Transcatheter edge to edge mitral valve repair: A Meta-analysis. Open
Background: Gender disparities in outcomes after mitral valve surgery are well known. There are only few studies reporting the influence of gender on outcomes following transcatheter edge to edge repair (TEER) of the mitral valve using Mit…
View article: Low left atrial voltage predicts lack of improvement in left ventricular systolic function post atrial fibrillation ablation in patients with systolic heart failure.
Low left atrial voltage predicts lack of improvement in left ventricular systolic function post atrial fibrillation ablation in patients with systolic heart failure. Open
Catheter Ablation of Atrial Fibrillation (AF) in patients with heart failure with reduced ejection fraction (HFrEF) is associated with decreased all-cause mortality, and improvement in left ventricular ejection fraction (EF). Predictors of…
View article: Incidence, Current Guidelines and Management of Gastrointestinal Bleedingafter Transcatheter Aortic Valve Replacement: A Systematic Review
Incidence, Current Guidelines and Management of Gastrointestinal Bleedingafter Transcatheter Aortic Valve Replacement: A Systematic Review Open
Background: There is a significant increase in morbidity and mortality in patients complicated by major bleeding following transcatheter aortic valve replacement (TAVR). It has become more challenging to manage such complications when the …
View article: Can glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors help in mitigating the risk of atrial fibrillation in patients with diabetes?
Can glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors help in mitigating the risk of atrial fibrillation in patients with diabetes? Open
The role of glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dipeptidyl peptidase-4 inhibitors (DPP-4i) in mitigating the risk of atrial fibrillation (AF) remains unknown. We interrogated the Food and Drug Administration’s Adverse …
View article: Anti-cancer Drugs Associated Atrial Fibrillation—An Analysis of Real-World Pharmacovigilance Data
Anti-cancer Drugs Associated Atrial Fibrillation—An Analysis of Real-World Pharmacovigilance Data Open
Background Several anti-cancer drugs have been linked to new onset atrial fibrillation (AF) but the true association of these drugs with AF is unknown. The FDA Adverse Event Reporting System (FAERS), a publicly available pharmacovigilance …
View article: Racial Disparities in Cardiovascular Disease Among Patients with Cancer in the United States: The Elephant in the Room
Racial Disparities in Cardiovascular Disease Among Patients with Cancer in the United States: The Elephant in the Room Open
View article: p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade
p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade Open
Squamous cell carcinoma driven by human papillomavirus (HPV) is more sensitive to DNA-damaging therapies than its HPV-negative counterpart. Here, we show that p16, the clinically used surrogate for HPV positivity, renders cells more sensit…
View article: Adverse events related to AtriCure EPi‐Sense Coagulation Device—Analysis of the FDA MAUDE database
Adverse events related to AtriCure EPi‐Sense Coagulation Device—Analysis of the FDA MAUDE database Open
Introduction The AtriCure EPi‐Sense Device is used for the hybrid convergent procedure, an emerging treatment for persistent atrial fibrillation (AF) and long‐standing persistent AF. However, data on the AE related to the EPi‐Sense device …
View article: Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function
Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function Open
Despite radiation forming the curative backbone of over 50% of malignancies, there are no genomically-driven radiosensitizers for clinical use. Herein we perform in vivo shRNA screening to identify targets generally associated with radiati…
View article: National trends in hospitalizations among patients with colorectal cancer in the United States
National trends in hospitalizations among patients with colorectal cancer in the United States Open
Colorectal cancer is the second leading cause of cancer-related death in the United States, with a rising incidence, especially in young adults. Care for patients with colorectal cancer is associated with significant healthcare costs and e…
View article: Cardiovascular complications associated with novel agents in the chronic lymphocytic leukemia armamentarium: A pharmacovigilance analysis
Cardiovascular complications associated with novel agents in the chronic lymphocytic leukemia armamentarium: A pharmacovigilance analysis Open
View article: Arrhythmias in patients with in-hospital alcohol withdrawal are associated with increased mortality: Insights from 1.5 million hospitalizations for alcohol withdrawal syndrome
Arrhythmias in patients with in-hospital alcohol withdrawal are associated with increased mortality: Insights from 1.5 million hospitalizations for alcohol withdrawal syndrome Open
View article: Adverse events related to Atricure EPi-Sense Coagulation Device - Analysis of the FDA MAUDE database
Adverse events related to Atricure EPi-Sense Coagulation Device - Analysis of the FDA MAUDE database Open
Introduction: The Atricure EPi-Sense Device is used for the hybrid convergent procedure, an emerging treatment for persistent atrial fibrillation and long standing persistent atrial fibrillation. However, data on the AE related to the EPi-…
View article: Multiple primary malignant neoplasms: a case of colonic adenocarcinoma and non-Hodgkin’s lymphoma on a background of ulcerative colitis
Multiple primary malignant neoplasms: a case of colonic adenocarcinoma and non-Hodgkin’s lymphoma on a background of ulcerative colitis Open
The presence of an adenocarcinoma and non-Hodgkin’s lymphoma in an individual is an uncommon finding. In this case report, we discuss the case of an elderly man presenting with a synchronous moderately differentiated colonic adenocarcinoma…
View article: p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade
p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade Open
Squamous cell carcinoma driven by human papillomavirus (HPV) is more sensitive to DNA-damaging therapies, such as radiation, than its HPV-negative counterpart. Here we show that p16, the clinically utilized surrogate for HPV positivity, re…
View article: Analysis of the impact of COVID-19 pandemic on house-staff in the USA: addressing the ripple effects
Analysis of the impact of COVID-19 pandemic on house-staff in the USA: addressing the ripple effects Open
Background: The novel corona virus has changed the way individuals interact with each other and society. In the medical sector, this has affected the residents and fellows who spend the majority of their time on the front lines. …
View article: Judicious use of incentive spirometry in resource limited times of COVID-19 pandemic
Judicious use of incentive spirometry in resource limited times of COVID-19 pandemic Open
View article: p16 Expression Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade.
p16 Expression Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade. Open
Squamous cell carcinoma driven by human papillomavirus (HPV) is more sensitive to DNA-damaging therapies, such as radiation, than its HPV-negative counterpart. Here we show that p16, the clinically utilized surrogate for HPV positivity, re…
View article: Prognostic value of cardiac biomarkers in COVID-19 infection
Prognostic value of cardiac biomarkers in COVID-19 infection Open
View article: p16 Expression Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade.
p16 Expression Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade. Open
Human papillomavirus (HPV) drives the development of squamous cell carcinoma at several sites, including the oropharynx. Generally, the presence of HPV renders a tumor more sensitive to DNA-damaging therapies such as radiation; however, th…