Aaloke Mody
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View article: Identifying care gaps along the HIV treatment failure cascade: A multistate analysis of viral load monitoring, re-suppression, and regimen switches in Zambia
Identifying care gaps along the HIV treatment failure cascade: A multistate analysis of viral load monitoring, re-suppression, and regimen switches in Zambia Open
Background Timely response to treatment failure is critical for improved outcomes and viral re-suppression among people living with HIV, but care gaps along the treatment failure cascade can occur due to delays by both clients (e.g., reten…
View article: REPRIEVE final results: What does it mean for guidelines in low‐ and middle‐income countries?
REPRIEVE final results: What does it mean for guidelines in low‐ and middle‐income countries? Open
Introduction The REPRIEVE study demonstrated significant reductions in major adverse cardiovascular events (MACE) with pitavastatin among people living with HIV (PWH) with low to moderate cardiovascular risk. Most MACE events occurred in h…
View article: Effect of a multicomponent, person-centred care intervention on client experience and HIV treatment outcomes in Zambia: a stepped-wedge, cluster-randomised trial
Effect of a multicomponent, person-centred care intervention on client experience and HIV treatment outcomes in Zambia: a stepped-wedge, cluster-randomised trial Open
View article: Addressing Hypertension and Diabetes through Community-Engaged Systems (ANDES) in Puno, Peru: rationale and study protocol for a hybrid type 2 effectiveness and implementation randomized controlled trial
Addressing Hypertension and Diabetes through Community-Engaged Systems (ANDES) in Puno, Peru: rationale and study protocol for a hybrid type 2 effectiveness and implementation randomized controlled trial Open
ClinicalTrials.gov, ID: NCT05524987 , Addressing Hypertension and Diabetes through Community-Engaged Systems in Puno, Peru (ANDES study), prospectively registered on September 1, 2021.
View article: Racial disparity in mortality from tuberculosis in the US between states with and without a history of Jim-Crow laws: an analysis of the Global Burden of Disease (GBD) and risk factors study, 1990 to 2019
Racial disparity in mortality from tuberculosis in the US between states with and without a history of Jim-Crow laws: an analysis of the Global Burden of Disease (GBD) and risk factors study, 1990 to 2019 Open
Even though the 1964 Civil Rights Act dismantled Jim-Crow statutes, racial inequities in TB burden experienced by past generations may still be felt in subsequent generations. Understanding the role of structural racism at the intersection…
View article: Integrating hypertension detection and management in HIV care in South Africa: protocol for a stepped-wedged cluster randomized effectiveness-implementation hybrid trial
Integrating hypertension detection and management in HIV care in South Africa: protocol for a stepped-wedged cluster randomized effectiveness-implementation hybrid trial Open
View article: Assessing the Response Results of an mHealth-Based Patient Experience Survey Among People Receiving HIV Care in Lusaka, Zambia: Cohort Study
Assessing the Response Results of an mHealth-Based Patient Experience Survey Among People Receiving HIV Care in Lusaka, Zambia: Cohort Study Open
Background This pilot study evaluates the effectiveness of mobile talk-time incentives in maintaining participation in a longitudinal mobile health (mHealth) data collection program among people living with HIV in Lusaka, Zambia. While mHe…
View article: Person‐centred interventions to improve patient−provider relationships for HIV services in low‐ and middle‐income countries: a systematic review
Person‐centred interventions to improve patient−provider relationships for HIV services in low‐ and middle‐income countries: a systematic review Open
Introduction Person‐centred care (PCC) has been recognized as a critical element in delivering quality and responsive health services. The patient−provider relationship, conceptualized at the core of PCC in multiple models, remains largely…
View article: Obesity is South Africa’s new HIV epidemic
Obesity is South Africa’s new HIV epidemic Open
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View article: Obesity is South Africa’s new HIV epidemic
Obesity is South Africa’s new HIV epidemic Open
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View article: Instrumental variables for implementation science: exploring context-dependent causal pathways between implementation strategies and evidence-based interventions
Instrumental variables for implementation science: exploring context-dependent causal pathways between implementation strategies and evidence-based interventions Open
Background The impact of both implementation strategies (IS) and evidence-based interventions (EBI) can vary across contexts, and a better understanding of how and why this occurs presents fundamental but challenging questions that impleme…
View article: Leveraging CD4 Cell Count at Entry Into Care to Monitor Success of Human Immunodeficiency Virus Prevention, Treatment, and Public Health Programming in the Greater St Louis Area Between 2017 and 2020
Leveraging CD4 Cell Count at Entry Into Care to Monitor Success of Human Immunodeficiency Virus Prevention, Treatment, and Public Health Programming in the Greater St Louis Area Between 2017 and 2020 Open
CD4 cell count at entry into human immunodeficiency virus (HIV) care is a useful indicator of success of multiple steps in HIV public health programming. We demonstrate that CD4 cell count at care initiation was stable in St Louis between …
View article: Comparison of patient exit interviews with unannounced standardised patients for assessing HIV service delivery in Zambia: a study nested within a cluster randomised trial
Comparison of patient exit interviews with unannounced standardised patients for assessing HIV service delivery in Zambia: a study nested within a cluster randomised trial Open
Objectives To compare unannounced standardised patient approach (eg, mystery clients) with typical exit interviews for assessing patient experiences in HIV care (eg, unfriendly providers, long waiting times). We hypothesise standardised pa…
View article: Provider perspectives on patient‐centredness: participatory formative research and rapid analysis methods to inform the design and implementation of a facility‐based HIV care improvement intervention in Zambia
Provider perspectives on patient‐centredness: participatory formative research and rapid analysis methods to inform the design and implementation of a facility‐based HIV care improvement intervention in Zambia Open
Introduction Implementation of patient‐centred care (PCC) practices in HIV treatment depends on healthcare workers’ (HCWs) perceptions of the acceptability, appropriateness and feasibility of such practices (e.g. use of intentional, metric…
View article: Patterns of person‐centred communications in public HIV clinics: a latent class analysis using the Roter interaction analysis system
Patterns of person‐centred communications in public HIV clinics: a latent class analysis using the Roter interaction analysis system Open
Introduction Poor client−provider communication is a critical barrier to long‐term retention in care among people living with HIV. However, standardized assessments of this key metric are limited in Africa. We used the Roter Interaction An…
View article: Mitigating the effects of COVID-19 on HIV treatment and care in Lusaka, Zambia: A before-after cohort study using mixed effects regression
Mitigating the effects of COVID-19 on HIV treatment and care in Lusaka, Zambia: A before-after cohort study using mixed effects regression Open
Introduction The Zambian Ministry of Health (MoH) issued COVID-19 mitigation guidance for HIV care immediately after the first COVID-19 case was confirmed in Zambia on 18 March 2020. The Centre for Infectious Disease Research in Zambia imp…
View article: Correction: Evaluation of kidney function among people living with HIV initiating antiretroviral therapy in Zambia
Correction: Evaluation of kidney function among people living with HIV initiating antiretroviral therapy in Zambia Open
[This corrects the article DOI: 10.1371/journal.pgph.0000124.].
View article: On-the-Go Adaptation of Implementation Approaches and Strategies in Health: Emerging Perspectives and Research Opportunities
On-the-Go Adaptation of Implementation Approaches and Strategies in Health: Emerging Perspectives and Research Opportunities Open
In many cases, implementation approaches (composed of one or more strategies) may need to change over time to work optimally. We use a literature review to inform a mechanistic analysis of such on-the-go adaptations. We suggest that such a…
View article: Cross-sectional study to assess depression among healthcare workers in Lusaka, Zambia during the COVID-19 pandemic
Cross-sectional study to assess depression among healthcare workers in Lusaka, Zambia during the COVID-19 pandemic Open
Objectives We sought to assess depression among healthcare workers (HCWs) in the context of COVID-19 in Lusaka Province, Zambia. Design This cross-sectional study is nested within a larger study, the Person-Centred Public Health for HIV Tr…
View article: Strengthening implementation guidelines for HIV service delivery: Considerations for future evidence generation and synthesis
Strengthening implementation guidelines for HIV service delivery: Considerations for future evidence generation and synthesis Open
Ingrid Eshun-Wilson and colleagues summarize gaps in primary HIV implementation research methods and reporting, and propose areas for future methodological development.
View article: Trajectories of re‐engagement: factors and mechanisms enabling patient return to HIV care in Zambia
Trajectories of re‐engagement: factors and mechanisms enabling patient return to HIV care in Zambia Open
Introduction While disengagement from HIV care threatens the health of persons living with HIV (PLWH) and incidence‐reduction targets, re‐engagement is a critical step towards positive outcomes. Studies that establish a deeper understandin…
View article: Additional file 1 of Instrumental variables for implementation science: exploring context-dependent causal pathways between implementation strategies and evidence-based interventions
Additional file 1 of Instrumental variables for implementation science: exploring context-dependent causal pathways between implementation strategies and evidence-based interventions Open
Additional file 1.
View article: 1906. Impact of Mask Mandate Timing on Community Transmission of SARS-CoV-2 in the St. Louis Metropolitan Area
1906. Impact of Mask Mandate Timing on Community Transmission of SARS-CoV-2 in the St. Louis Metropolitan Area Open
Background Mask mandates have been a widely used public health tool during the COVID-19 pandemic, but how to optimize their impact in the setting of concurrent but spontaneous population-level behavior changes due to rising case counts is …
View article: Multistate Modeling of Clinical Trajectories and Outcomes in the ICU: A Proof-of-Concept Evaluation of Acute Kidney Injury Among Critically Ill Patients With COVID-19
Multistate Modeling of Clinical Trajectories and Outcomes in the ICU: A Proof-of-Concept Evaluation of Acute Kidney Injury Among Critically Ill Patients With COVID-19 Open
IMPORTANCE: Multistate models yield high-fidelity analyses of the dynamic state transition and temporal dimensions of a clinical condition’s natural history, offering superiority over aggregate modeling techniques for addressing these type…
View article: Hospital trajectories and early predictors of clinical outcomes differ between SARS-CoV-2 and influenza pneumonia
Hospital trajectories and early predictors of clinical outcomes differ between SARS-CoV-2 and influenza pneumonia Open
View article: “Provider discretionary power practices to support implementation of patient-centered HIV care in Lusaka, Zambia”
“Provider discretionary power practices to support implementation of patient-centered HIV care in Lusaka, Zambia” Open
Introduction Traditional patient-provider relationships privilege the providers, as they possess the formal authority and clinical knowledge applied to address illness, but providers also have discretion over how they exercise their power …
View article: Quantifying inequities in COVID-19 vaccine distribution over time by social vulnerability, race and ethnicity, and location: A population-level analysis in St. Louis and Kansas City, Missouri
Quantifying inequities in COVID-19 vaccine distribution over time by social vulnerability, race and ethnicity, and location: A population-level analysis in St. Louis and Kansas City, Missouri Open
Background Equity in vaccination coverage is a cornerstone for a successful public health response to COVID-19. To deepen understanding of the extent to which vaccination coverage compares with initial strategies for equitable vaccination,…
View article: Temporal changes in paediatric and adolescent HIV outcomes across the care continuum in Zambia: an interrupted time-series analysis
Temporal changes in paediatric and adolescent HIV outcomes across the care continuum in Zambia: an interrupted time-series analysis Open
View article: Quantifying Inequities in COVID-19 Vaccine Distribution Over Time by social vulnerability, race and ethnicity, and location: A Population-Level Analysis in St. Louis and Kansas City, Missouri
Quantifying Inequities in COVID-19 Vaccine Distribution Over Time by social vulnerability, race and ethnicity, and location: A Population-Level Analysis in St. Louis and Kansas City, Missouri Open
BACKGROUND Equity in vaccination coverage is a cornerstone to a successful public health response to COVID-19. To deepen understand of the extent to which vaccination coverage compared to initial strategies for equitable vaccination, we ex…
View article: Data Velocity in HIV-Related Implementation Research: Estimating Time From Funding to Publication
Data Velocity in HIV-Related Implementation Research: Estimating Time From Funding to Publication Open
Background: Given available effective biomedical and behavioral prevention and treatment interventions, HIV-related implementation research (IR) is expanding. The rapid generation and dissemination of IR to inform guidelines and practice h…