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View article: The effect of policy measures, school holidays and travel on the incidence of SARS-CoV-2 infection in children and adults in Estonia from 2021 to 2022
The effect of policy measures, school holidays and travel on the incidence of SARS-CoV-2 infection in children and adults in Estonia from 2021 to 2022 Open
Purpose The policy measures implemented during the COVID-19 pandemic, travel and school holidays could have influenced the spread of SARS-CoV-2 infection in children and adults differently. We aimed to determine the effect of policy measur…
View article: Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022
Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022 Open
Purpose We aimed to describe SARS-CoV-2 lineages and diversity in children and adults in Estonia and similarity to travel-related cases and neighbouring countries. Methods SARS-CoV-2 sequences in 2021–2022 from a nationwide study were incl…
View article: SARS-CoV-2 clade dynamics and their associations with hospitalisations during the first two years of the COVID-19 pandemic
SARS-CoV-2 clade dynamics and their associations with hospitalisations during the first two years of the COVID-19 pandemic Open
Background The COVID-19 pandemic was characterised by rapid waves of disease, carried by the emergence of new and more infectious SARS-CoV-2 virus variants. How the pandemic unfolded in various locations during its first two years has yet …
View article: Consensus statement from the first RdRp Summit: advancing RNA virus discovery at scale across communities
Consensus statement from the first RdRp Summit: advancing RNA virus discovery at scale across communities Open
Improved RNA virus understanding is critical to studying animal and plant health, and environmental processes. However, the continuous and rapid RNA virus evolution makes their identification and characterization challenging. While recent …
View article: Risk of SARS-CoV-2 infection and hospitalization in individuals with natural, vaccine-induced and hybrid immunity: a retrospective population-based cohort study from Estonia
Risk of SARS-CoV-2 infection and hospitalization in individuals with natural, vaccine-induced and hybrid immunity: a retrospective population-based cohort study from Estonia Open
A large proportion of the world’s population has some form of immunity against SARS-CoV- 2, through either infection (‘natural’), vaccination or both (‘hybrid’). This retrospective cohort study used data on SARS-CoV-2, vaccination, and hos…
View article: Choosing an Optimal Solvent Is Crucial for Obtaining Cell-Penetrating Peptide Nanoparticles with Desired Properties and High Activity in Nucleic Acid Delivery
Choosing an Optimal Solvent Is Crucial for Obtaining Cell-Penetrating Peptide Nanoparticles with Desired Properties and High Activity in Nucleic Acid Delivery Open
Cell-penetrating peptides (CPPs) are highly promising transfection agents that can deliver various compounds into living cells, including nucleic acids (NAs). Positively charged CPPs can form non-covalent complexes with negatively charged …
View article: Divalent Metal Ions Boost Effect of Nucleic Acids Delivered by Cell-Penetrating Peptides
Divalent Metal Ions Boost Effect of Nucleic Acids Delivered by Cell-Penetrating Peptides Open
Cell-penetrating peptides (CPPs) are promising tools for the transfection of various substances, including nucleic acids, into cells. The aim of the current work was to search for novel safe and effective approaches for enhancing transfect…
View article: Human TRMT112-Methyltransferase Network Consists of Seven Partners Interacting with a Common Co-Factor
Human TRMT112-Methyltransferase Network Consists of Seven Partners Interacting with a Common Co-Factor Open
Methylation is an essential epigenetic modification mainly catalysed by S-Adenosyl methionine-dependent methyltransferases (MTases). Several MTases require a cofactor for their metabolic stability and enzymatic activity. TRMT112 is a small…
View article: Divalent metal ions boost effect of nucleic acids delivered by cell-penetrating peptides
Divalent metal ions boost effect of nucleic acids delivered by cell-penetrating peptides Open
Cell-penetrating peptides (CPPs) are promising tools for transfection of various substances, including nucleic acids, into cells. The aim of current work was to search for novel safe and effective approaches for enhancing transfection effi…
View article: The Common Partner of Several Methyltransferases TRMT112 Regulates the Expression of N6AMT1 Isoforms in Mammalian Cells
The Common Partner of Several Methyltransferases TRMT112 Regulates the Expression of N6AMT1 Isoforms in Mammalian Cells Open
Methylation is a widespread modification occurring in DNA, RNA and proteins. The N6AMT1 (HEMK2) protein has DNA N6-methyladenine as well as the protein glutamine and histone lysine methyltransferase activities. The human genome encodes two…
View article: The Third Annual Meeting of the European Virus Bioinformatics Center
The Third Annual Meeting of the European Virus Bioinformatics Center Open
The Third Annual Meeting of the European Virus Bioinformatics Center (EVBC) took place in Glasgow, United Kingdom, 28–29 March 2019. Virus bioinformatics has become central to virology research, and advances in bioinformatics have led to i…
View article: Protein Structure-Guided Hidden Markov Models (HMMs) as A Powerful Method in the Detection of Ancestral Endogenous Viral Elements
Protein Structure-Guided Hidden Markov Models (HMMs) as A Powerful Method in the Detection of Ancestral Endogenous Viral Elements Open
It has been believed for a long time that the transfer and fixation of genetic material from RNA viruses to eukaryote genomes is very unlikely. However, during the last decade, there have been several cases in which “virus-to-host” gene tr…
View article: cRegions—a tool for detecting conserved cis-elements in multiple sequence alignment of diverged coding sequences
cRegions—a tool for detecting conserved cis-elements in multiple sequence alignment of diverged coding sequences Open
Identifying cis-acting elements and understanding regulatory mechanisms of a gene is crucial to fully understand the molecular biology of an organism. In general, it is difficult to identify previously uncharacterised cis-acting elements w…
View article: The Enigmatic Origin of Papillomavirus Protein Domains
The Enigmatic Origin of Papillomavirus Protein Domains Open
Almost a century has passed since the discovery of papillomaviruses. A few decades of research have given a wealth of information on the molecular biology of papillomaviruses. Several excellent studies have been performed looking at the lo…
View article: Did Viruses Evolve As a Distinct Supergroup from Common Ancestors of Cells?
Did Viruses Evolve As a Distinct Supergroup from Common Ancestors of Cells? Open
The evolutionary origins of viruses according to marker gene phylogenies, as well as their relationships to the ancestors of host cells remains unclear. In a recent article Nasir and Caetano-Anollés reported that their genome-scale phyloge…
View article: Did viruses evolve as a distinct supergroup from common ancestors of cells?
Did viruses evolve as a distinct supergroup from common ancestors of cells? Open
The evolutionary origins of viruses according to marker gene phylogenies, as well as their relationships to the ancestors of host cells remains unclear. In a recent article Nasir and Caetano-Anollés reported that their genome-scale phyloge…
View article: Characterization of the nuclear matrix targeting sequence (NMTS) of the BPV1 E8/E2 protein — the shortest known NMTS
Characterization of the nuclear matrix targeting sequence (NMTS) of the BPV1 E8/E2 protein — the shortest known NMTS Open
Technological advantages in sequencing and proteomics have revealed the remarkable diversity of alternative protein isoforms. Typically, the localization and functions of these isoforms are unknown and cannot be predicted. Also the localiz…