Aaron B. Baker
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View article: A human pluripotent stem cell tri-culture platform to elucidate microglial regulation of retinal ganglion cells in neuroinflammation
A human pluripotent stem cell tri-culture platform to elucidate microglial regulation of retinal ganglion cells in neuroinflammation Open
Optic neuropathies, including glaucoma, are characterized by the progressive degeneration of retinal ganglion cells (RGCs), ultimately leading to irreversible vision loss. Increasing evidence implicates microglia, the resident immune cells…
View article: A Computational Model of Mechanical Stretching of Cultured Cells on a Flexible Membrane
A Computational Model of Mechanical Stretching of Cultured Cells on a Flexible Membrane Open
Mechanical forces applied to cells are known to regulate a wide variety of biological processes. Recent studies have supported that mechanical forces can cause nuclear deformation, leading to significant alterations in the gene expression …
View article: Mechanical Rejuvenation of Mesenchymal Stem Cells from Aged Patients
Mechanical Rejuvenation of Mesenchymal Stem Cells from Aged Patients Open
Mesenchymal stem cells (MSC) are an appealing therapeutic cell type for many diseases. However, patients with poor health or advanced age often have MSCs with poor regenerative properties. A major limiter of MSC therapies is cellular senes…
View article: A high throughput blood–brain barrier model incorporating shear stress with improved predictive power for drug discovery
A high throughput blood–brain barrier model incorporating shear stress with improved predictive power for drug discovery Open
The blood–brain barrier is a key structure regulating the health of the brain and access of drugs and pathogens to neural tissue. Shear stress is a key regulator of the blood–brain barrier; however, the commonly used multi-well vitro model…
View article: Transmembrane Stem Factor Nanodiscs Enhanced Revascularization in a Hind Limb Ischemia Model in Diabetic, Hyperlipidemic Rabbits
Transmembrane Stem Factor Nanodiscs Enhanced Revascularization in a Hind Limb Ischemia Model in Diabetic, Hyperlipidemic Rabbits Open
Therapies to revascularize ischemic tissue have long been a goal for the treatment of vascular disease and other disorders. Therapies using stem cell factor (SCF), also known as a c-Kit ligand, had great promise for treating ischemia for m…
View article: Increased let‐7d‐5p in non‐alcoholic fatty liver promotes insulin resistance and is a potential blood biomarker for diagnosis
Increased let‐7d‐5p in non‐alcoholic fatty liver promotes insulin resistance and is a potential blood biomarker for diagnosis Open
Background and Aims The molecular mechanisms driving non‐alcoholic fatty liver disease (NAFLD) are poorly understood; however, microRNAs might play a key role in these processes. We hypothesize that let‐7d‐5p could contribute to the pathop…
View article: Inhibition of somatostatin enhances the long-term metabolic outcomes of sleeve gastrectomy in mice
Inhibition of somatostatin enhances the long-term metabolic outcomes of sleeve gastrectomy in mice Open
Bariatric surgery is an effective obesity treatment, leading to weight loss and improvement in glycemia, that is characterized by hypersecretion of gastrointestinal hormones. However, weight regain and relapse of hyperglycemia are not unco…
View article: The effects of strain history on aortic valve interstitial cell activation in a 3D hydrogel environment
The effects of strain history on aortic valve interstitial cell activation in a 3D hydrogel environment Open
Aortic valves (AVs) undergo unique stretch histories that include high rates and magnitudes. While major differences in deformation patterns have been observed between normal and congenitally defective bicuspid aortic valves (BAVs), the re…
View article: Supplementary Table 1 from Comparative Effects of Two Different Forms of Selenium on Oxidative Stress Biomarkers in Healthy Men: A Randomized Clinical Trial
Supplementary Table 1 from Comparative Effects of Two Different Forms of Selenium on Oxidative Stress Biomarkers in Healthy Men: A Randomized Clinical Trial Open
PDF file - 29K, Changes in urinary oxidative stress biomarkers by baseline selenium levels.
View article: Supplementary Table 1 from Comparative Effects of Two Different Forms of Selenium on Oxidative Stress Biomarkers in Healthy Men: A Randomized Clinical Trial
Supplementary Table 1 from Comparative Effects of Two Different Forms of Selenium on Oxidative Stress Biomarkers in Healthy Men: A Randomized Clinical Trial Open
PDF file - 29K, Changes in urinary oxidative stress biomarkers by baseline selenium levels.
View article: Data from Comparative Effects of Two Different Forms of Selenium on Oxidative Stress Biomarkers in Healthy Men: A Randomized Clinical Trial
Data from Comparative Effects of Two Different Forms of Selenium on Oxidative Stress Biomarkers in Healthy Men: A Randomized Clinical Trial Open
Epidemiologic and laboratory studies indicate that dietary selenium protects against prostate cancer. Results from clinical trials suggest that selenium-enriched yeast (SY) but not selenomethionine (SeMet) may be effective at reducing pros…
View article: Data from Comparative Effects of Two Different Forms of Selenium on Oxidative Stress Biomarkers in Healthy Men: A Randomized Clinical Trial
Data from Comparative Effects of Two Different Forms of Selenium on Oxidative Stress Biomarkers in Healthy Men: A Randomized Clinical Trial Open
Epidemiologic and laboratory studies indicate that dietary selenium protects against prostate cancer. Results from clinical trials suggest that selenium-enriched yeast (SY) but not selenomethionine (SeMet) may be effective at reducing pros…
View article: Transmembrane Stem Factor Nanodiscs Enhanced Revascularization in a Hind Limb Ischemia Model in Diabetic, Hyperlipidemic Rabbits
Transmembrane Stem Factor Nanodiscs Enhanced Revascularization in a Hind Limb Ischemia Model in Diabetic, Hyperlipidemic Rabbits Open
Therapies to revascularize ischemic tissue have long been a goal for the treatment of vascular disease and other disorders. Therapies using stem cell factor (SCF), also known as a c-Kit ligand, had great promise for treating ischemia for m…
View article: Syndecan-4 Proteoliposomes Enhance Revascularization in a Rabbit Hind Limb Ischemia Model of Peripheral Ischemia
Syndecan-4 Proteoliposomes Enhance Revascularization in a Rabbit Hind Limb Ischemia Model of Peripheral Ischemia Open
Regenerative therapeutics for treating peripheral arterial disease are an appealing strategy for creating more durable solutions for limb ischemia. In this work, we performed preclinical testing of an injectable formulation of syndecan-4 p…
View article: Transmembrane stem cell factor protein therapeutics enhance revascularization in ischemia without mast cell activation
Transmembrane stem cell factor protein therapeutics enhance revascularization in ischemia without mast cell activation Open
Stem cell factor (SCF) is a cytokine that regulates hematopoiesis and other biological processes. While clinical treatments using SCF would be highly beneficial, these have been limited by toxicity related to mast cell activation. Transmem…
View article: Rhamnan Sulfate Reduces Atherosclerotic Plaque Formation and Vascular Inflammation
Rhamnan Sulfate Reduces Atherosclerotic Plaque Formation and Vascular Inflammation Open
Objective While lipid-lowering drugs have become a mainstay of clinical therapy these treatments only slow the progression of the disease and can have side effects. Thus, new treatment options are needed to supplement the effects of lipid …
View article: E-059 Eptifibatide bridging therapy for staged carotid artery stenting and cardiac surgery
E-059 Eptifibatide bridging therapy for staged carotid artery stenting and cardiac surgery Open
Background Prophylactic carotid artery stenting (CAS) is an effective strategy to reduce perioperative stroke in patients with severe carotid stenosis who require cardiothoracic surgery (CTS). Staging both procedures (CAS-CTS) during a sin…
View article: Biomechanical regulation of breast cancer metastasis and progression
Biomechanical regulation of breast cancer metastasis and progression Open
Physical activity has been consistently linked to decreased incidence of breast cancer and a substantial increase in the length of survival of patients with breast cancer. However, the understanding of how applied physical forces directly …
View article: Laser nanobubbles induce immunogenic cell death in breast cancer
Laser nanobubbles induce immunogenic cell death in breast cancer Open
Laser nanobubbles induce dendritic cell activation in breast cancer cells.
View article: A Rapid, Nondestructive Method for Vascular Network Visualization
A Rapid, Nondestructive Method for Vascular Network Visualization Open
The quantitative analysis of blood vessel networks is an important component in many animal models of disease. We describe a nondestructive technique for blood vessel imaging that visualizes in situ vasculature in harvested tissues. The me…