Aaron B. Wong
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View article: Discrimination training affects stimulus generalization in mice during Pavlovian eyeblink conditioning
Discrimination training affects stimulus generalization in mice during Pavlovian eyeblink conditioning Open
The delicate balance between discrimination and generalization of responses is crucial for survival in our ever-changing environment. In particular, it is important to understand how stimulus discrimination affects the level of stimulus ge…
View article: Sodium salicylate improves detection of amplitude-modulated sound in mice
Sodium salicylate improves detection of amplitude-modulated sound in mice Open
Salicylate is commonly used to induce tinnitus in animals, but its underlying mechanism of action is still debated. We therefore tested its effects on the firing properties of neurons in the mouse inferior colliculus (IC). Salicylate induc…
View article: Discrimination training affects stimulus generalization in mice during Pavlovian eyeblink conditioning
Discrimination training affects stimulus generalization in mice during Pavlovian eyeblink conditioning Open
The delicate balance between generalization and discrimination of responses is crucial for survival in our ever-changing environment. In particular, it is important to understand how stimulus discrimination affects the level of stimulus ge…
View article: Headplate Installation and Craniotomy for Awake In Vivo Electrophysiological Recordings or Two-Photon Imaging of the Mouse Inferior Colliculus
Headplate Installation and Craniotomy for Awake In Vivo Electrophysiological Recordings or Two-Photon Imaging of the Mouse Inferior Colliculus Open
The inferior colliculus (IC) is an important processing center in the auditory system, which also receives non-auditory sensory input. The IC consists of several subnuclei whose functional role in (non-) auditory processing and plastic res…
View article: Genetic barcoding systematically compares genes in del(5q) MDS and reveals a central role for <i>CSNK1A1</i> in clonal expansion
Genetic barcoding systematically compares genes in del(5q) MDS and reveals a central role for <i>CSNK1A1</i> in clonal expansion Open
How genetic haploinsufficiency contributes to the clonal dominance of hematopoietic stem cells (HSCs) in del(5q) myelodysplastic syndrome (MDS) remains unresolved. Using a genetic barcoding strategy, we performed a systematic comparison on…
View article: Plug-and-play adaptive optics for commercial laser scanningfluorescence microscopes based on an adaptive lens
Plug-and-play adaptive optics for commercial laser scanningfluorescence microscopes based on an adaptive lens Open
In this Letter, we present a solution for simple implementation of adaptive optics in any existing laser scanning fluorescence microscope. Adaptive optics are implemented by the introduction of a multiactuator adaptive lens between the mic…
View article: Tonotopic and non-auditory organization of the mouse dorsal inferior colliculus revealed by two-photon imaging
Tonotopic and non-auditory organization of the mouse dorsal inferior colliculus revealed by two-photon imaging Open
The dorsal (DCIC) and lateral cortices (LCIC) of the inferior colliculus are major targets of the auditory and non-auditory cortical areas, suggesting a role in complex multimodal information processing. However, relatively little is known…
View article: TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells
TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells Open
Despite the canonical homogeneous character of its organization, the cerebellum plays differential computational roles in distinct sensorimotor behaviors. Previously, we showed that Purkinje cell (PC) activity differs between zebrin-negati…
View article: Author response: TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells
Author response: TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Despite the canonical homogeneous characte…
View article: Tonotopic and multisensory organization of the mouse dorsal inferior colliculus revealed by two-photon imaging
Tonotopic and multisensory organization of the mouse dorsal inferior colliculus revealed by two-photon imaging Open
The dorsal (DCIC) and lateral cortices (LCIC) of the inferior colliculus are major targets of the auditory and non-auditory cortical areas, suggesting a role in complex multimodal information processing. However, relatively little is known…
View article: TRPC3 is essential for functional heterogeneity of cerebellar Purkinje cells
TRPC3 is essential for functional heterogeneity of cerebellar Purkinje cells Open
Despite the canonical homogenous character of its organization, the cerebellum plays differential computational roles in distinct types of sensorimotor behaviors. However, the molecular and cell physiological underpinnings are unclear. Her…