Aaron S. Burton
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View article: Eliglustat and cardiac comorbidities in Gaucher disease: a pharmacogenomic approach to safety and efficacy
Eliglustat and cardiac comorbidities in Gaucher disease: a pharmacogenomic approach to safety and efficacy Open
Introduction Gaucher disease (GD), a lysosomal storage disorder, results from the accumulation of glycosphingolipids due to deficient lysosomal glucocerebrosidase activity. This pathological accumulation triggers immune activation, which p…
View article: Eliglustat substrate reduction therapy in children with Gaucher disease type 1
Eliglustat substrate reduction therapy in children with Gaucher disease type 1 Open
Importance Gaucher disease (GD) is a rare lysosomal storage disorder with limited treatment options for pediatric patients. Oral substrate reduction therapy (SRT) with eliglustat offers a potential alternative, particularly for those with …
View article: Abundant ammonia and nitrogen-rich soluble organic matter in samples from asteroid (101955) Bennu
Abundant ammonia and nitrogen-rich soluble organic matter in samples from asteroid (101955) Bennu Open
Organic matter in meteorites reveals clues about early Solar System chemistry and the origin of molecules important to life, but terrestrial exposure complicates interpretation. Samples returned from the B-type asteroid Bennu by the Origin…
View article: Future of the Search for Life: Workshop Report
Future of the Search for Life: Workshop Report Open
The 2-week, virtual Future of the Search for Life science and engineering workshop brought together more than 100 scientists, engineers, and technologists in March and April 2022 to provide their expert opinion on the interconnections betw…
View article: Investigating the impact of x‐ray computed tomography imaging on soluble organic matter in the Murchison meteorite: Implications for Bennu sample analyses
Investigating the impact of x‐ray computed tomography imaging on soluble organic matter in the Murchison meteorite: Implications for Bennu sample analyses Open
X‐ray computed tomography (XCT) is a valuable reconnaissance tool for three‐dimensional imaging and identification of distinct lithologies in extraterrestrial samples. It will be used as part of the preliminary examination of samples retur…
View article: The nature of insoluble organic matter in Sutter's Mill and Murchison carbonaceous chondrites: Testing the effect of x‐ray computed tomography and exploring parent body organic molecular evolution
The nature of insoluble organic matter in Sutter's Mill and Murchison carbonaceous chondrites: Testing the effect of x‐ray computed tomography and exploring parent body organic molecular evolution Open
This study analyzed samples of the Murchison and Sutter's Mill carbonaceous chondrite meteorites in support of the future analysis of samples returned from the asteroid (10155) Bennu by the OSIRIS‐REx (Origins, Spectral Interpretation, Res…
View article: The Role of the CuCl Active Complex in the Stereoselectivity of the Salt-Induced Peptide Formation Reaction: Insights from Density Functional Theory Calculations
The Role of the CuCl Active Complex in the Stereoselectivity of the Salt-Induced Peptide Formation Reaction: Insights from Density Functional Theory Calculations Open
The salt-induced peptide formation (SIPF) reaction is a prebiotically plausible mechanism for the spontaneous polymerization of amino acids into peptides on early Earth. Experimental investigations of the SIPF reaction have found that in c…
View article: Diverse organic-mineral associations in Jezero crater, Mars
Diverse organic-mineral associations in Jezero crater, Mars Open
The presence and distribution of preserved organic matter on the surface of Mars can provide key information about the Martian carbon cycle and the potential of the planet to host life throughout its history. Several types of organic molec…
View article: Aqueously altered igneous rocks sampled on the floor of Jezero crater, Mars
Aqueously altered igneous rocks sampled on the floor of Jezero crater, Mars Open
The Perseverance rover landed in Jezero crater, Mars, to investigate ancient lake and river deposits. We report observations of the crater floor, below the crater’s sedimentary delta, finding that the floor consists of igneous rocks altere…
View article: The SHERLOC Calibration Target on the Mars 2020 Perseverance Rover: Design, Operations, Outreach, and Future Human Exploration Functions
The SHERLOC Calibration Target on the Mars 2020 Perseverance Rover: Design, Operations, Outreach, and Future Human Exploration Functions Open
The Scanning Habitable Environments with Raman and Luminescence for Organics and Chemicals (SHERLOC) is a robotic arm-mounted instrument onboard NASA’s Perseverance rover. SHERLOC combines imaging via two cameras with both Raman and fluore…
View article: COSPAR Sample Safety Assessment Framework (SSAF)
COSPAR Sample Safety Assessment Framework (SSAF) Open
The Committee on Space Research (COSPAR) Sample Safety Assessment Framework (SSAF) has been developed by a COSPAR appointed Working Group. The objective of the sample safety assessment would be to evaluate whether samples returned from Mar…
View article: Chirality in Organic and Mineral Systems: A Review of Reactivity and Alteration Processes Relevant to Prebiotic Chemistry and Life Detection Missions
Chirality in Organic and Mineral Systems: A Review of Reactivity and Alteration Processes Relevant to Prebiotic Chemistry and Life Detection Missions Open
Chirality is a central feature in the evolution of biological systems, but the reason for biology’s strong preference for specific chiralities of amino acids, sugars, and other molecules remains a controversial and unanswered question in o…
View article: Visualization and identification of single meteoritic organic molecules by atomic force microscopy
Visualization and identification of single meteoritic organic molecules by atomic force microscopy Open
Using high‐resolution atomic force microscopy (AFM) with CO‐functionalized tips, we atomically resolved individual molecules from Murchison meteorite samples. We analyzed powdered Murchison meteorite material directly, as well as processed…
View article: Shortcoming of Measuring Patient Satisfaction’s Association With Anemia-Based Cardiovascular Risk in End-Stage Kidney Disease Patients
Shortcoming of Measuring Patient Satisfaction’s Association With Anemia-Based Cardiovascular Risk in End-Stage Kidney Disease Patients Open
No correlation was observed between patient satisfaction with hemoglobin. Although patient satisfaction among hemodialysis patients was mostly "very good" or "excellent", nearly half of the patients were anemic, and some had higher hemoglo…
View article: Perseverance’s Scanning Habitable Environments with Raman and Luminescence for Organics and Chemicals (SHERLOC) Investigation
Perseverance’s Scanning Habitable Environments with Raman and Luminescence for Organics and Chemicals (SHERLOC) Investigation Open
The Scanning Habitable Environments with Raman and Luminescence for Organics and Chemicals (SHERLOC) is a robotic arm-mounted instrument on NASA’s Perseverance rover. SHERLOC has two primary boresights. The Spectroscopy boresight generates…
View article: The Scientific Need for a Dedicated Interplanetary Dust Instrument at Mars
The Scientific Need for a Dedicated Interplanetary Dust Instrument at Mars Open
International audience
View article: Real-Time Culture-Independent Microbial Profiling Onboard the International Space Station Using Nanopore Sequencing
Real-Time Culture-Independent Microbial Profiling Onboard the International Space Station Using Nanopore Sequencing Open
For the past two decades, microbial monitoring of the International Space Station (ISS) has relied on culture-dependent methods that require return to Earth for analysis. This has a number of limitations, with the most significant being bi…
View article: Analysis of amino acids, hydroxy acids, and amines in CR chondrites
Analysis of amino acids, hydroxy acids, and amines in CR chondrites Open
The abundances, relative distributions, and enantiomeric and isotopic compositions of amines, amino acids, and hydroxy acids in Miller Range (MIL) 090001 and MIL 090657 meteorites were determined. Chiral distributions and isotopic composit…
View article: Off Earth Identification of Bacterial Populations Using 16S rDNA Nanopore Sequencing
Off Earth Identification of Bacterial Populations Using 16S rDNA Nanopore Sequencing Open
The MinION sequencer has made in situ sequencing feasible in remote locations. Following our initial demonstration of its high performance off planet with Earth-prepared samples, we developed and tested an end-to-end, sample-to-sequencer p…
View article: The CM carbonaceous chondrite regolith Diepenveen
The CM carbonaceous chondrite regolith Diepenveen Open
A carbonaceous chondrite was recovered immediately after the fall near the village of Diepenveen in the Netherlands on October 27, 1873, but came to light only in 2012. Analysis of sodium and poly‐aromatic hydrocarbon content suggests litt…
View article: Radiation Tolerance of Nanopore Sequencing Technology for Life Detection on Mars and Europa
Radiation Tolerance of Nanopore Sequencing Technology for Life Detection on Mars and Europa Open
The search for life beyond Earth is a key motivator in space exploration. Informational polymers, like DNA and RNA, are key biosignatures for life as we know it. The MinION is a miniature DNA sequencer based on versatile nanopore technolog…
View article: Sequencing DNA, RNA and related molecules as a tool to advance space exploration
Sequencing DNA, RNA and related molecules as a tool to advance space exploration Open
As humans seek to return to the Moon, and eventually to Mars and beyond, new challenges must be overcome to keep astronauts safe and healthy. This includes protecting crew members from harmful organisms in their environment, treating infec…
View article: Insights into Abiotically-Generated Amino Acid Enantiomeric Excesses Found in Meteorites
Insights into Abiotically-Generated Amino Acid Enantiomeric Excesses Found in Meteorites Open
Biology exhibits homochirality, in that only one of two possible molecular configurations (called enantiomers) is used in both proteins and nucleic acids. The origin of this phenomenon is currently unknown, as nearly all known abiotic mech…
View article: Chiral Selectivity as a Bridge to Homochirality
Chiral Selectivity as a Bridge to Homochirality Open
In abiotic reactions, equal mixtures of L- and D- amino acid enantiomers are produced unless conditions that favor one enantiomer over the other are present. Understanding how the transition from racemic, abiotic chemistry to homochiral po…
View article: Nanopore detection of bacterial DNA base modifications
Nanopore detection of bacterial DNA base modifications Open
The common bacterial base modification N6-methyladenine (m 6 A) is involved in many pathways related to an organism’s ability to survive and interact with its environment. Recent research has shown that nanopore sequencing can detect m 5 C…
View article: Thermal Studies of Ammonium Cyanide Reactions: A Model for Thermal Alteration of Prebiotic Compounds in Meteorite Parent Bodies
Thermal Studies of Ammonium Cyanide Reactions: A Model for Thermal Alteration of Prebiotic Compounds in Meteorite Parent Bodies Open
Organic compounds in carbonaceous chondrites were likely transformed by a variety of parent body processes including thermal and aqueous processing. Here, we analyzed ammonium cyanide reactions that were heated at different temperatures an…
View article: Nanopore sequencing in microgravity
Nanopore sequencing in microgravity Open
Rapid DNA sequencing and analysis has been a long-sought goal in remote research and point-of-care medicine. In microgravity, DNA sequencing can facilitate novel astrobiological research and close monitoring of crew health, but spaceflight…