Aaron Campigotto
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View article: Comparison of six COVID-19 serology assays for detection of antibodies from patients infected with ancestral and a spectrum of SARS-CoV-2 variants
Comparison of six COVID-19 serology assays for detection of antibodies from patients infected with ancestral and a spectrum of SARS-CoV-2 variants Open
Serology assays against spike, receptor binding domain (RBD) and nucleocapsid proteins of the severe acute respiratory syndrome coronavirus 2 are essential for serosurveillance. We performed a comparison of four medium-to-high throughput c…
View article: Risk Factors for Severe Disease Among Children Hospitalized With Respiratory Syncytial Virus
Risk Factors for Severe Disease Among Children Hospitalized With Respiratory Syncytial Virus Open
Importance A resurgence of respiratory syncytial virus (RSV)–associated acute respiratory tract infection (ARI) was observed in 2022 and 2023 after the COVID-19 pandemic. Changes in the demographic characteristics, disease severity, and ou…
View article: Invasive Group A Streptococcal Infection in Children, 1992-2023
Invasive Group A Streptococcal Infection in Children, 1992-2023 Open
Importance The resurgence of invasive group A streptococcal (iGAS) infections and progress in GAS vaccine development emphasize the importance of understanding current trends in the epidemiology of iGAS. Objective To describe the epidemiol…
View article: Performance of the World Health Organization (WHO) severe acute respiratory infection (SARI) case definitions in hospitalized children and youth: cross-sectional study
Performance of the World Health Organization (WHO) severe acute respiratory infection (SARI) case definitions in hospitalized children and youth: cross-sectional study Open
View article: Persistence and decay of neutralizing antibody responses elicited by SARS-CoV-2 infection and hybrid immunity in a Canadian cohort
Persistence and decay of neutralizing antibody responses elicited by SARS-CoV-2 infection and hybrid immunity in a Canadian cohort Open
A major challenge with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has been assessing the intensity, dynamics, and determinants of the antibody responses after i…
View article: P-2052. Pre-existing Humoral Immunity to Seasonal Coronaviruses and Effect on SARS-CoV-2 Antibody Responses on SARS-CoV-2 Vaccination and Infection
P-2052. Pre-existing Humoral Immunity to Seasonal Coronaviruses and Effect on SARS-CoV-2 Antibody Responses on SARS-CoV-2 Vaccination and Infection Open
Background High homology and potential cross-reactive immune responses between SARS-CoV-2 and seasonal human coronaviruses (HCoVs) have been described by several studies. However, the role of pre-existing immunity to HCoVs in the outcome o…
View article: P-1290. Invasive group A streptococcal infection in children in Toronto, Canada
P-1290. Invasive group A streptococcal infection in children in Toronto, Canada Open
Background Rising cases of invasive group A streptococcus (iGAS) in children have been reported globally. We assessed the epidemiology of pediatric iGAS over three decades. The annual incidence of invasive GAS infections in children in Tor…
View article: P-643. Incidence and Clinical Characteristics of Invasive Group A Streptococcal Infections in Underhoused Adults in Toronto, Canada
P-643. Incidence and Clinical Characteristics of Invasive Group A Streptococcal Infections in Underhoused Adults in Toronto, Canada Open
Background Post-pandemic increases of invasive group A streptococcal disease (iGAS) have been reported in many areas of the world; increased risk associated with illicit intravenous (IV) drug use has also been identified. Methods Since 199…
View article: Burden of SARS‐CoV‐2 infection prior to vaccine eligibility among immunocompromised children aged 1–11 years at a pediatric tertiary referral hospital in Toronto, Canada
Burden of SARS‐CoV‐2 infection prior to vaccine eligibility among immunocompromised children aged 1–11 years at a pediatric tertiary referral hospital in Toronto, Canada Open
SARS‐CoV‐2 seroprevalence reflects the efficacy of pandemic infection prevention and control measures. We performed anti‐spike IgG serological testing on residual sera of children 1–11 years old at a tertiary care referral center between O…
View article: Epidemiology of carbapenemase-producing Enterobacterales carriage in a paediatric tertiary health care centre of Ontario, Canada
Epidemiology of carbapenemase-producing Enterobacterales carriage in a paediatric tertiary health care centre of Ontario, Canada Open
Introduction: The epidemiology of carbapenemase-producing Enterobacterales (CPE) in hospitalized children in low endemicity settings is not well known. We aim to describe it in a large tertiary paediatric health care centre in Canada. Meth…
View article: Automatic urine cultures from catheter-obtained samples—time to implement a practice change to improve value
Automatic urine cultures from catheter-obtained samples—time to implement a practice change to improve value Open
Objectives Urine cultures are often automatically obtained after urinary catheterization in young children, even in the absence of pyuria, to test for urinary tract infections (UTIs). Although this practice conflicts with some newer guidel…
View article: Detection of OXA-181 Carbapenemase in <i>Shigella flexneri</i>
Detection of OXA-181 Carbapenemase in <i>Shigella flexneri</i> Open
We report the detection of OXA-181 carbapenemase in an azithromycin-resistant Shigella spp. bacteria in an immunocompromised patient. The emergence of OXA-181 in Shigella spp. bacteria raises concerns about the global dissemination of carb…
View article: Measuring waning protection from seasonal influenza vaccination during nine influenza seasons, Ontario, Canada, 2010/11 to 2018/19
Measuring waning protection from seasonal influenza vaccination during nine influenza seasons, Ontario, Canada, 2010/11 to 2018/19 Open
Background Waning immunity from seasonal influenza vaccination can cause suboptimal protection during peak influenza activity. However, vaccine effectiveness studies assessing waning immunity using vaccinated and unvaccinated individuals a…
View article: Disproportionate Rates of COVID-19 Among Black Canadian Communities: Lessons from a Cross-Sectional Study in the First Year of the Pandemic
Disproportionate Rates of COVID-19 Among Black Canadian Communities: Lessons from a Cross-Sectional Study in the First Year of the Pandemic Open
View article: Healthcare-associated viral respiratory infections at a Canadian tertiary pediatric hospital: a seven-year retrospective analysis
Healthcare-associated viral respiratory infections at a Canadian tertiary pediatric hospital: a seven-year retrospective analysis Open
Healthcare-associated viral respiratory infections (HA-VRIs) in a pediatric hospital decreased from 1.44 per 1000 patient days in 2019–0.43 and 0.38 in 2020–2021 during the SARS-CoV-2 pandemic but increased to 1.35 in 2022. The increase in…
View article: Effectiveness of Influenza Vaccination During Pregnancy Against Laboratory-Confirmed Seasonal Influenza Among Infants Under 6 Months of Age in Ontario, Canada
Effectiveness of Influenza Vaccination During Pregnancy Against Laboratory-Confirmed Seasonal Influenza Among Infants Under 6 Months of Age in Ontario, Canada Open
Background Randomized trials conducted in low- and middle-income settings demonstrated efficacy of influenza vaccination during pregnancy against influenza infection among infants <6 months of age. However, vaccine effectiveness (VE) es…
View article: 1823. Disproportionate Rates of COVID-19 Among Black Canadian Communities: Lessons from the First Year of the Pandemic
1823. Disproportionate Rates of COVID-19 Among Black Canadian Communities: Lessons from the First Year of the Pandemic Open
Background Black North American communities have been disproportionately affected by COVID-19. These data have been largely based on case counts, hospitalizations and mortality data. Serologic testing enables a more complete determination …
View article: Severe acute hepatitis of unknown etiology in a large cohort of children
Severe acute hepatitis of unknown etiology in a large cohort of children Open
Background: We evaluated the proportion, clinical features, and outcomes of previously healthy children presenting to a large Canadian quaternary pediatric center with severe acute hepatitis of unknown etiology. Methods: All patients with …
View article: 24 Characteristics and Outcomes of Hospitalized Children by SARS-Cov-2 Lineage: An IMPACT Surveillance Network Analysis
24 Characteristics and Outcomes of Hospitalized Children by SARS-Cov-2 Lineage: An IMPACT Surveillance Network Analysis Open
Introduction/Background Changes in relative virulence of SARS-CoV-2 lineages among children remain poorly understood, yet are important considerations for vaccination and health resource management. Further evidence is needed to assess the…
View article: Prevalence of Low-Frequency, Antiviral Resistance Variants in SARS-CoV-2 Isolates in Ontario, Canada, 2020-2023
Prevalence of Low-Frequency, Antiviral Resistance Variants in SARS-CoV-2 Isolates in Ontario, Canada, 2020-2023 Open
Importance Nirmatrelvir-ritonavir is an oral antiviral medication that improves outcomes in SARS-CoV-2 infections. However, there is concern that antiviral resistance will develop and that these viruses could be selected for after treatmen…
View article: Estimating the Incidence of First RSV Hospitalization in Children Born in Ontario, Canada
Estimating the Incidence of First RSV Hospitalization in Children Born in Ontario, Canada Open
Background Respiratory syncytial virus (RSV) contributes significantly to morbidity in children, placing substantial burdens on health systems, thus RSV vaccine development and program implementation are a public health priority. More data…
View article: Evaluating the Impact of Statin Use on Influenza Vaccine Effectiveness and Influenza Infection in Older Adults
Evaluating the Impact of Statin Use on Influenza Vaccine Effectiveness and Influenza Infection in Older Adults Open
Background Older adults are recommended to receive influenza vaccination annually, and many use statins. Statins have immunomodulatory properties that might modify influenza vaccine effectiveness (VE) and alter influenza infection risk. Me…
View article: Utility of SARS-CoV-2 Genomic Sequencing for Understanding Transmission and School Outbreaks
Utility of SARS-CoV-2 Genomic Sequencing for Understanding Transmission and School Outbreaks Open
Objective: An understanding of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) transmission in schools is important. It is often difficult, using epidemiological information alone, to determine whether cases associated with sc…
View article: The <scp>SARS‐CoV</scp>‐2‐positive donor in pediatric organ transplantation
The <span>SARS‐CoV</span>‐2‐positive donor in pediatric organ transplantation Open
All authors declare that they have no conflicts of interest related to this study. Data sharing is not applicable to this article as no new data were created or analyzed in this study.
View article: Hépatite aiguë grave d’étiologie inconnue chez les enfants
Hépatite aiguë grave d’étiologie inconnue chez les enfants Open
[Voir la version anglaise de l’article ici: www.cmaj.ca/lookup/doi/10.1503/cmaj.220956][1] En date du 8 juillet 2022, on a signalé 1010 cas probables à l’Organisation mondiale de la santé[1][2], dont 21 cas au Canada[2][3]. À savoir si cet…
View article: A Practical Workflow for the Identification of Aspergillus, Fusarium, Mucorales by MALDI-TOF MS: Database, Medium, and Incubation Optimization
A Practical Workflow for the Identification of Aspergillus, Fusarium, Mucorales by MALDI-TOF MS: Database, Medium, and Incubation Optimization Open
There is an increasing body of literature on the utility of MALDI-TOF MS in the identification of filamentous fungi. However, the process still lacks standardization.
View article: A Prolonged Outbreak of Human Adenovirus A31 (HAdV-A31) Infection on a Pediatric Hematopoietic Stem Cell Transplantation Ward with Whole Genome Sequencing Evidence of International Linkages
A Prolonged Outbreak of Human Adenovirus A31 (HAdV-A31) Infection on a Pediatric Hematopoietic Stem Cell Transplantation Ward with Whole Genome Sequencing Evidence of International Linkages Open
A surge in hematopoietic stem cell transplantation (HSCT) human adenovirus A31 (HAdV-A31) infections was initially observed in late 2014/2015 at SickKids (SK) Hospital, Toronto, Canada. In response, enhanced laboratory monitoring for all a…
View article: 37 Accessible and Specialized COVID-19 Testing for Children and Youth with Medical Complexity
37 Accessible and Specialized COVID-19 Testing for Children and Youth with Medical Complexity Open
Background COVID-19 testing for symptomatic individuals is a key public health measure for infection prevention and control. However, COVID-19 testing can be uncomfortable without appropriate supports and can lead to testing hesitancy amon…
View article: 59 Understanding asymptomatic testing uptake amongst school aged children and staff for SARS-CoV-2 testing in elementary and secondary schools
59 Understanding asymptomatic testing uptake amongst school aged children and staff for SARS-CoV-2 testing in elementary and secondary schools Open
Background Enhanced health and safety measures, such as symptom screening, physical distancing, cohorting, masking, and asymptomatic testing for children have been introduced into schools to prevent SARS-CoV-2 transmission. Although asympt…
View article: Severe acute hepatitis of unknown cause in children
Severe acute hepatitis of unknown cause in children Open
As of July 8, 2022, 1010 probable cases have been reported to the World Health Organization (WHO),[1][1] including 21 in Canada.[2][2] Whether this represents an increase from baseline remains uncertain. The cause is also unclear; however,…