Aaron R. Cox
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View article: A Mouse Model of Lipoatrophy Reveals Relationships Between Beige Fat Appearance and Female Fertility
A Mouse Model of Lipoatrophy Reveals Relationships Between Beige Fat Appearance and Female Fertility Open
White adipose tissue (WAT) performs vital metabolic and endocrine functions, but roles in female reproduction remain understudied and poorly understood. Here, we report that female mice experiencing progressive lipoatrophy after knockout o…
View article: The microRNA miR-30a blocks adipose tissue fibrosis accumulation in obesity
The microRNA miR-30a blocks adipose tissue fibrosis accumulation in obesity Open
White adipose tissue (WAT) fibrosis occurring in obesity contributes to the inflammatory and metabolic comorbidities of insulin resistance and type 2 diabetes, yet the mechanisms involved remain poorly understood. Here, we report a role fo…
View article: Beige fat appearance during lipoatrophy reveals trade-offs between metabolic homeostasis and female fertility
Beige fat appearance during lipoatrophy reveals trade-offs between metabolic homeostasis and female fertility Open
White adipose tissue (WAT) meets the energetic demands required for estrous cycle regularity, ovulation, and reproductive success in women. Here, we report WAT loss and subsequent female-specific compensatory beige fat recruitment impact m…
View article: A Comprehensive Atlas of AAV Tropism in the Mouse
A Comprehensive Atlas of AAV Tropism in the Mouse Open
Summary Gene therapy with Adeno-Associated Viral (AAV) vectors requires knowledge of their tropism within the body. Here we analyze the tropism of ten naturally occurring AAV serotypes (AAV3B, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAVrh8, AA…
View article: The Hepatokine Orosomucoid 2 Mediates Beneficial Metabolic Effects of Bile Acids
The Hepatokine Orosomucoid 2 Mediates Beneficial Metabolic Effects of Bile Acids Open
Bile acids (BAs) are pleiotropic regulators of metabolism. Elevated levels of hepatic and circulating BAs improve energy metabolism in peripheral organs, but the precise mechanisms underlying the metabolic benefits and harm still need to b…
View article: The hepatokine orosomucoid 2 mediates beneficial metabolic effects of bile acids
The hepatokine orosomucoid 2 mediates beneficial metabolic effects of bile acids Open
Bile acids (BAs) are pleiotropic regulators of metabolism. Elevated levels of hepatic and circulating BAs improve energy metabolism in peripheral organs, but the precise mechanisms underlying the metabolic benefits and harm still need to b…
View article: The hepatokine orosomucoid 2 mediates beneficial metabolic effects of bile acids
The hepatokine orosomucoid 2 mediates beneficial metabolic effects of bile acids Open
Bile acids (BAs) are pleiotropic regulators of metabolism. Elevated levels of hepatic and circulating BAs improve energy metabolism in peripheral organs, but the precise mechanisms underlying the metabolic benefits and harm still need to b…
View article: Adipose Tissue Dysfunction and Energy Balance Paradigms in People Living With HIV
Adipose Tissue Dysfunction and Energy Balance Paradigms in People Living With HIV Open
Over the past 4 decades, the clinical care of people living with HIV (PLWH) evolved from treatment of acute opportunistic infections to the management of chronic, noncommunicable comorbidities. Concurrently, our understanding of adipose ti…
View article: Vitamin B2 enables regulation of fasting glucose availability
Vitamin B2 enables regulation of fasting glucose availability Open
Flavin adenine dinucleotide (FAD) interacts with flavoproteins to mediate oxidation-reduction reactions required for cellular energy demands. Not surprisingly, mutations that alter FAD binding to flavoproteins cause rare inborn errors of m…
View article: Vitamin B2 enables peroxisome proliferator-activated receptor α regulation of fasting glucose availability
Vitamin B2 enables peroxisome proliferator-activated receptor α regulation of fasting glucose availability Open
Flavin adenine dinucleotide (FAD) interacts with flavoproteins to mediate oxidation-reduction reactions required for cellular energy demands. Not surprisingly, mutations that alter FAD binding to flavoproteins cause rare inborn errors of m…
View article: Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis
Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis Open
DNA Methyltransferase 3 A (DNMT3A) is an important facilitator of differentiation of both embryonic and hematopoietic stem cells. Heterozygous germline mutations in DNMT3A lead to Tatton-Brown-Rahman Syndrome (TBRS), characterized by obesi…
View article: Combining an Integrated Sensor Array with Machine Learning for the Simultaneous Quantification of Multiple Cations in Aqueous Mixtures
Combining an Integrated Sensor Array with Machine Learning for the Simultaneous Quantification of Multiple Cations in Aqueous Mixtures Open
The direct quantification of multiple ions in aqueous mixtures is achieved by combining an automated machine learning pipeline with transient potentiometric data obtained from a single miniaturized array of polymeric sensors electrodeposit…
View article: Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis
Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis Open
DNA Methyltransferase 3A (DNMT3A) is an important facilitator of differentiation of both embryonic and hematopoietic stem cells. Heterozygous germline mutations in DNMT3A lead to Tatton-Brown-Rahman Syndrome (TBRS), characterized by obesit…
View article: Accumulation of auranofin in white adipose tissues lowers leptin levels and exerts anti-diabetic effects
Accumulation of auranofin in white adipose tissues lowers leptin levels and exerts anti-diabetic effects Open
SUMMARY Low-grade, sustained inflammation in white adipose tissue (WAT) characterizes obesity and frequently coincides with insulin resistance and type 2 diabetes (T2D). However, pharmacological targeting of WAT inflammation lacks durable …
View article: HIV-1 Viral Protein R Couples Metabolic Inflexibility With White Adipose Tissue Thermogenesis
HIV-1 Viral Protein R Couples Metabolic Inflexibility With White Adipose Tissue Thermogenesis Open
Persons living with HIV (PLWH) manifest chronic disorders of brown and white adipose tissues that lead to diabetes and metabolic syndrome. The mechanisms that link viral factors to defective adipose tissue function and abnormal energy bala…
View article: HIV-1 Viral Protein R Couples Metabolic inflexibility with White Adipose Tissue Thermogenesis
HIV-1 Viral Protein R Couples Metabolic inflexibility with White Adipose Tissue Thermogenesis Open
Persons living with HIV (PLWH) manifest chronic disorders of brown and white adipose tissues that lead to diabetes and metabolic syndrome. The mechanisms that link viral factors to defective adipose tissue function and abnormal energy bala…
View article: HIV-1 Viral Protein R Couples Metabolic inflexibility with White Adipose Tissue Thermogenesis
HIV-1 Viral Protein R Couples Metabolic inflexibility with White Adipose Tissue Thermogenesis Open
Persons living with HIV (PLWH) manifest chronic disorders of brown and white adipose tissues that lead to diabetes and metabolic syndrome. The mechanisms that link viral factors to defective adipose tissue function and abnormal energy bala…
View article: Deficiency of Stat1 in CD11c+ Cells Alters Adipose Tissue Inflammation and Improves Metabolic Dysfunctions in Mice Fed High-Fat Diet
Deficiency of Stat1 in CD11c+ Cells Alters Adipose Tissue Inflammation and Improves Metabolic Dysfunctions in Mice Fed High-Fat Diet Open
CD11c+ macrophages/dendritic cells (MDCs) are increased and display classically activated M1-like phenotype in obese adipose tissue (AT) and may contribute to AT inflammation and insulin resistance. Stat1 is a key transcription factor for …
View article: Deficiency of Stat1 in CD11c+ Cells Alters Adipose Tissue Inflammation and Improves Metabolic Dysfunctions in Mice Fed a High-Fat Diet
Deficiency of Stat1 in CD11c+ Cells Alters Adipose Tissue Inflammation and Improves Metabolic Dysfunctions in Mice Fed a High-Fat Diet Open
CD11c+ macrophages/dendritic cells (MDCs) are increased and display the classically activated M1-like phenotype in obese adipose tissue (AT) and may contribute to AT inflammation and insulin resistance. Stat1 is a key transcription factor …
View article: Deficiency of Stat1 in CD11c+ Cells Alters Adipose Tissue Inflammation and Improves Metabolic Dysfunctions in Mice Fed High-Fat Diet
Deficiency of Stat1 in CD11c+ Cells Alters Adipose Tissue Inflammation and Improves Metabolic Dysfunctions in Mice Fed High-Fat Diet Open
CD11c+ macrophages/dendritic cells (MDCs) are increased and display classically activated M1-like phenotype in obese adipose tissue (AT) and may contribute to AT inflammation and insulin resistance. Stat1 is a key transcription factor for …
View article: STAT1 dissociates adipose tissue inflammation from insulin sensitivity in obesity
STAT1 dissociates adipose tissue inflammation from insulin sensitivity in obesity Open
Obesity fosters low-grade inflammation in white adipose tissue (WAT) that may contribute to the insulin resistance that characterizes type 2 diabetes mellitus (T2DM). However, the causal relationship of these events remains unclear. The es…