Aaron Gardner
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View article: Utility of long read Nanopore sequencing as a tool for rapid insight into the host response in patients infected with SARS-CoV-2 or influenza A virus at point-of-care
Utility of long read Nanopore sequencing as a tool for rapid insight into the host response in patients infected with SARS-CoV-2 or influenza A virus at point-of-care Open
Long read sequencing with Nanopore provides a platform for rapid, accessible, and flexible sequencing of nucleic acids, which is advantageous when faced with an outbreak or biological threat, particularly in situations where there is a lac…
View article: Influence of geography, stroke timing, and weather conditions on transport and workflow times: Results from a longitudinal 5-year Canadian provincial registry
Influence of geography, stroke timing, and weather conditions on transport and workflow times: Results from a longitudinal 5-year Canadian provincial registry Open
Background In areas with high population spread such as Saskatchewan, it can be challenging to provide timely endovascular stroke treatment (EVT) to patients living far away from comprehensive stroke centres (CSC). We assessed the associat…
View article: 458 Medicines management of long-term conditions during the COVID19 pandemic: a narrative systematic review
458 Medicines management of long-term conditions during the COVID19 pandemic: a narrative systematic review Open
Introduction Due to lockdown measures associated with the COVID 19 pandemic (1), there were substantial changes to healthcare delivery, including the suspension of face-to-face medical appointments, expansion of telehealth and changes to m…
View article: Blood gene expression predicts intensive care unit admission in hospitalised patients with COVID-19
Blood gene expression predicts intensive care unit admission in hospitalised patients with COVID-19 Open
Background The COVID-19 pandemic has created pressure on healthcare systems worldwide. Tools that can stratify individuals according to prognosis could allow for more efficient allocation of healthcare resources and thus improved patient o…
View article: Evaluating the Immune Response in Treatment-Naive Hospitalised Patients With Influenza and COVID-19
Evaluating the Immune Response in Treatment-Naive Hospitalised Patients With Influenza and COVID-19 Open
The worldwide COVID-19 pandemic has claimed millions of lives and has had a profound effect on global life. Understanding the body’s immune response to SARS-CoV-2 infection is crucial in improving patient management and prognosis. In this …
View article: Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2
Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2 Open
The nasal epithelium is a plausible entry point for SARS-CoV-2, a site of pathogenesis and transmission, and may initiate the host response to SARS-CoV-2. Antiviral interferon (IFN) responses are critical to outcome of SARS-CoV-2. Yet litt…
View article: Airborne Mid-Infrared Cavity enhanced Absorption spectrometer (AMICA)
Airborne Mid-Infrared Cavity enhanced Absorption spectrometer (AMICA) Open
We describe the Airborne Mid-Infrared Cavity enhanced Absorption spectrometer (AMICA) designed to measure trace gases in situ on research aircraft using Off-Axis Integrated Cavity Output Spectroscopy (OA-ICOS). AMICA contains two largely i…
View article: Distinct immune responses in patients infected with influenza or SARS-CoV-2, and in COVID-19 survivors, characterised by transcriptomic and cellular abundance differences in blood
Distinct immune responses in patients infected with influenza or SARS-CoV-2, and in COVID-19 survivors, characterised by transcriptomic and cellular abundance differences in blood Open
Background The worldwide pandemic caused by SARS-CoV-2 has claimed millions of lives and has had a profound effect on global life. Understanding the pathogenicity of the virus and the body’s response to infection is crucial in improving pa…
View article: Comment on amt-2021-28
Comment on amt-2021-28 Open
Abstract. We describe the Airborne Mid-Infrared Cavity enhanced Absorption spectrometer (AMICA) designed to measure trace gases in situ on research aircraft using Off-Axis Integrated Cavity Output Spectroscopy (OA-ICOS). AMICA contains two…
View article: Airborne Mid-Infrared Cavity enhanced Absorption spectrometer(AMICA)
Airborne Mid-Infrared Cavity enhanced Absorption spectrometer(AMICA) Open
We describe the Airborne Mid-Infrared Cavity enhanced Absorption spectrometer (AMICA) designed to measure trace gases in situ on research aircraft using Off-Axis Integrated Cavity Output Spectroscopy (OA-ICOS). AMICA contains two largely i…
View article: Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2
Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2 Open
The nasal epithelium is a plausible entry point for SARS-CoV-2, a site of pathogenesis and transmission, and may initiate the host response to SARS-CoV-2. Antiviral interferon (IFN) responses are critical to outcome of SARS-CoV-2. Yet litt…
View article: Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis
Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis Open
Most patients with cystic fibrosis (CF) suffer from acute and chronic pulmonary infections with bacterial pathogens, which often determine their life quality and expectancy. Previous studies have demonstrated a downregulation of the acid c…
View article: Clinical and molecular characterization of the R751L-CFTR mutation
Clinical and molecular characterization of the R751L-CFTR mutation Open
Cystic fibrosis (CF) arises from mutations in the CF transmembrane conductance regulator ( CFTR) gene, resulting in progressive and life-limiting respiratory disease. R751L is a rare CFTR mutation that is poorly characterized. Our aims wer…
View article: Trends in nontuberculous mycobacteria infection in children and young people with cystic fibrosis
Trends in nontuberculous mycobacteria infection in children and young people with cystic fibrosis Open
Nontuberculous mycobacteria (NTM) infection is of growing concern in cystic fibrosis (CF). UK CF Registry data were analyzed from 2016 to 2018. Prevalence of infection stabilized in the pediatric age-group during this period but remained s…
View article: Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis
Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis Open
Rationale: In cystic fibrosis the major cause of morbidity and mortality is lung disease characterized by inflammation and infection. The influence of sphingolipid metabolism is poorly understood with a lack of studies using human airway m…
View article: Real-Time, Semi-Automated Fluorescent Measurement of the Airway Surface Liquid pH of Primary Human Airway Epithelial Cells
Real-Time, Semi-Automated Fluorescent Measurement of the Airway Surface Liquid pH of Primary Human Airway Epithelial Cells Open
In recent years, the importance of mucosal surface pH in the airways has been highlighted by its ability to regulate airway surface liquid (ASL) hydration, mucus viscosity and activity of antimicrobial peptides, key parameters involved in …
View article: Real-Time, Semi-Automated Fluorescent Measurement of the Airway Surface Liquid pH of Primary Human Airway Epithelial Cells
Real-Time, Semi-Automated Fluorescent Measurement of the Airway Surface Liquid pH of Primary Human Airway Epithelial Cells Open
In recent years, the importance of mucosal surface pH in the airways has been highlighted by its ability to regulate airway surface liquid (ASL) hydration, mucus viscosity and activity of antimicrobial peptides, key parameters involved in …
View article: Epidemiology of Nontuberculous Mycobacteria Infection in Children and Young People With Cystic Fibrosis: Analysis of UK Cystic Fibrosis Registry
Epidemiology of Nontuberculous Mycobacteria Infection in Children and Young People With Cystic Fibrosis: Analysis of UK Cystic Fibrosis Registry Open
NTM infection is of increasing prevalence in the UK pediatric CF population. This study highlights the urgent need for work to establish effective treatment and prevention strategies for NTM infection in young people with CF.
View article: A multifunctional bispecific antibody against Pseudomonas aeruginosa as a potential therapeutic strategy.
A multifunctional bispecific antibody against Pseudomonas aeruginosa as a potential therapeutic strategy. Open
Pseudomonas aeruginosa ( P. aeruginosa ) is a Gram-negative bacteria that is responsible for significant morbidity and mortality in human populations (1). It is a common cause of hospital-acquired and ventilator-associated pneumonia, oppo…