Aaron J. Berliner
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View article: Guardians of the Mitochondria: Space Mitochondria 2.0 Systemic Analysis Reveals Bioenergetic Dysregulation Across Species
Guardians of the Mitochondria: Space Mitochondria 2.0 Systemic Analysis Reveals Bioenergetic Dysregulation Across Species Open
View article: Nitrogen accountancy in space agriculture
Nitrogen accountancy in space agriculture Open
Food production and pharmaceutical synthesis are posited as essential biotechnologies for facilitating human exploration beyond Earth. These technologies not only offer critical green space and food agency to astronauts but also promise to…
View article: Isolation and characterization of a <i>Halomonas</i> species for non-axenic growth-associated production of bio-polyesters from sustainable feedstocks
Isolation and characterization of a <i>Halomonas</i> species for non-axenic growth-associated production of bio-polyesters from sustainable feedstocks Open
Biodegradable plastics are urgently needed to replace petroleum-derived polymeric materials and prevent their accumulation in the environment. To this end, we isolated and characterized a halophilic and alkaliphilic bacterium from the Grea…
View article: Isolation and Characterization of a<i>Halomonas</i>Species for Non-Axenic Growth-Associated Production of Bio-Polyesters from Sustainable Feedstocks
Isolation and Characterization of a<i>Halomonas</i>Species for Non-Axenic Growth-Associated Production of Bio-Polyesters from Sustainable Feedstocks Open
Biodegradable plastics are urgently needed to replace petroleum-derived polymeric materials and prevent their accumulation in the environment. To this end, we isolated and characterized a halophilic and alkaliphilic bacterium from the Grea…
View article: Nitrogen Accountancy in Space Agriculture
Nitrogen Accountancy in Space Agriculture Open
Food production and pharmaceutical synthesis are posited as essential biotechnologies for facilitating human exploration beyond Earth. These technologies not only offer critical green space and food agency to astronauts but also promise to…
View article: Domains of life sciences in spacefaring: what, where, and how to get involved
Domains of life sciences in spacefaring: what, where, and how to get involved Open
The integration of biology and spacefaring has led to the development of three interrelated fields: Astrobiology, Bioastronautics, and Space Bioprocess Engineering. Astrobiology is concerned with the study of the origin, evolution, distrib…
View article: Radioactive contamination in feral dogs in the Chernobyl exclusion zone: Population body-burden survey and implications for human radiation exposure
Radioactive contamination in feral dogs in the Chernobyl exclusion zone: Population body-burden survey and implications for human radiation exposure Open
This report describes a two-year effort to survey the internal 137 Cs and external β -emitter contamination present in the feral dog population near the Chernobyl nuclear power plant (ChNPP) site, and to understand the potential for human …
View article: Microbial biomanufacturing for space-exploration—what to take and when to make
Microbial biomanufacturing for space-exploration—what to take and when to make Open
View article: Nuclear history, politics, and futures from (A)toms-to(Z)oom: Design and deployment of a remote-learning special-topics course for nuclear engineering education
Nuclear history, politics, and futures from (A)toms-to(Z)oom: Design and deployment of a remote-learning special-topics course for nuclear engineering education Open
To address the lack of familiarity with nuclear history common among nuclear engineers and physicists, we outline the design and deployment of a special-topics course entitled “NE290: Nuclear History, Politics, and Futures” throughout whic…
View article: Towards an extension of equivalent system mass for human exploration missions on Mars
Towards an extension of equivalent system mass for human exploration missions on Mars Open
NASA mission systems proposals are often compared using an equivalent system mass (ESM) framework, wherein all elements of a technology to deliver an effect—its components, operations, and logistics of delivery—are converted to effective m…
View article: Biomanufacturing for Space-Exploration – What to Take and When to Make
Biomanufacturing for Space-Exploration – What to Take and When to Make Open
As renewed interest in human space-exploration intensifies, a coherent and modernized strategy for mission-design and planning has become increasingly crucial. Biotechnology has emerged as a promising approach to increase mission resilienc…
View article: Space bioprocess engineering on the horizon
Space bioprocess engineering on the horizon Open
Space bioprocess engineering (SBE) is an emerging multi-disciplinary field to design, realize, and manage biologically-driven technologies specifically with the goal of supporting life on long term space missions. SBE considers synthetic b…
View article: Photovoltaics-Driven Power Production Can Support Human Exploration on Mars
Photovoltaics-Driven Power Production Can Support Human Exploration on Mars Open
A central question surrounding possible human exploration of Mars is whether crewed missions can be supported by available technologies using in situ resources. Here, we show that photovoltaics-based power systems would be adequate and pra…
View article: Radioactive Contamination in Feral Dogs in the Chernobyl Exclusion Zone: Population Body-Burden Survey and Implications for Human Radiation Exposure
Radioactive Contamination in Feral Dogs in the Chernobyl Exclusion Zone: Population Body-Burden Survey and Implications for Human Radiation Exposure Open
This report describes a two-year effort to survey the internal 137 Cs and external β -emitter contamination present in the feral dog population near the Chernobyl nuclear power plant (ChNPP) site, and to quantify the potential for human ra…
View article: Data-Driven Flow-Map Models for Data-Efficient Discovery of Dynamics and Fast Uncertainty Quantification of Biological and Biochemical Systems
Data-Driven Flow-Map Models for Data-Efficient Discovery of Dynamics and Fast Uncertainty Quantification of Biological and Biochemical Systems Open
Computational models are increasingly used to investigate and predict the complex dynamics of biological and biochemical systems. Nevertheless, governing equations of a biochemical system may not be (fully) known, which would necessitate l…
View article: Data-Driven Flow-Map Models for Data-Efficient Discovery of Dynamics and Fast Uncertainty Quantification of Biological and Biochemical Systems
Data-Driven Flow-Map Models for Data-Efficient Discovery of Dynamics and Fast Uncertainty Quantification of Biological and Biochemical Systems Open
Computational models are increasingly used to investigate and predict the complex dynamics of biological and biochemical systems. Nevertheless, governing equations of a biochemical system may not be (fully) known, which would necessitate l…
View article: Nuclear Policy Re(V)iew from the Periscope: SLBM and SLCM Policy Options for the 2022 Biden White House
Nuclear Policy Re(V)iew from the Periscope: SLBM and SLCM Policy Options for the 2022 Biden White House Open
Advances in nuclear weapon technologies from – and the corresponding evolution in the threat landscape posed by – non-allied nations over the past four years underscores the exigency of the United States (U.S) in updating its stated nation…
View article: Space Bioprocess Engineering on the Horizon
Space Bioprocess Engineering on the Horizon Open
Reinvigorated public interest in human space exploration has led to the need to address the science and engineering challenges described by NASA's Space Technology Grand Challenges (STGCs) for expanding the human presence in space. Here we…
View article: Space Bioprocess Engineering on the Horizon
Space Bioprocess Engineering on the Horizon Open
Reinvigorated public interest in human space exploration has led to the need to address the science and engineering challenges described by NASA's Space Technology Grand Challenges (STGCs) for expanding the human presence in space. Here we…
View article: Nuclear History, Politics, and Futures from (A)toms-to(Z)oom: Design and Deployment of a Remote-Learning Special-Topics Course For Nuclear Engineering Education
Nuclear History, Politics, and Futures from (A)toms-to(Z)oom: Design and Deployment of a Remote-Learning Special-Topics Course For Nuclear Engineering Education Open
To address the lack of familiarity with nuclear history common among nuclear engineers and physicists, we outline the design and deployment of a special-topics course entitled "NE290: Nuclear History, Politics, and Futures" across which we…
View article: Novel Aromatic Polyhydroxyalkanoates from Engineered <i>Cupriavidus necator</i> H16: Expanding Bio-Polyester Synthesis from Renewable Feedstocks
Novel Aromatic Polyhydroxyalkanoates from Engineered <i>Cupriavidus necator</i> H16: Expanding Bio-Polyester Synthesis from Renewable Feedstocks Open
Synthetic materials are integral components of consumable and durable goods and are indispensable in the modern world. Polyesters are the most versatile bulk- and specialty-polymers but their production is not sustainable and their fate at…
View article: Photovoltaics-driven power production can support human exploration on Mars
Photovoltaics-driven power production can support human exploration on Mars Open
A central question surrounding possible human exploration of Mars is whether crewed missions can be supported by available technologies using in situ resources. Here, we show that photovoltaics-based power systems would be adequate and pra…
View article: Evaluating the Cost of Pharmaceutical Purification for a Long-Duration Space Exploration Medical Foundry
Evaluating the Cost of Pharmaceutical Purification for a Long-Duration Space Exploration Medical Foundry Open
There are medical treatment vulnerabilities in longer-duration space missions present in the current International Space Station crew health care system with risks, arising from spaceflight-accelerated pharmaceutical degradation and resupp…
View article: Towards a Biomanufactory on Mars
Towards a Biomanufactory on Mars Open
A crewed mission to and from Mars may include an exciting array of enabling biotechnologies that leverage inherent mass, power, and volume advantages over traditional abiotic approaches. In this perspective, we articulate the scientific an…
View article: Evaluating the cost of pharmaceutical purification for a long-duration space exploration medical foundry
Evaluating the cost of pharmaceutical purification for a long-duration space exploration medical foundry Open
There are medical treatment vulnerabilities in longer-duration space missions present in the current International Space Station crew health care system with risks, arising from spaceflight-accelerated pharmaceutical degradation and resupp…
View article: Molecular pharming to support human life on the moon, mars, and beyond
Molecular pharming to support human life on the moon, mars, and beyond Open
Space missions have always assumed that the risk of spacecraft malfunction far outweighs the risk of human system failure. This assumption breaks down for longer duration exploration missions and exposes vulnerabilities in space medical sy…
View article: Extension of Equivalent System Mass for Human Exploration Missions on Mars
Extension of Equivalent System Mass for Human Exploration Missions on Mars Open
NASA mission systems proposals are often compared using an equivalent system mass (ESM) framework wherein all elements of technology to deliver an effect- its components, operations and logistics of delivery- are converted to effective mas…
View article: Towards a Biomanufactory on Mars
Towards a Biomanufactory on Mars Open
A crewed mission to and from Mars may include an exciting array of enabling biotechnologies that leverage inherent mass, power, and volume advantages over traditional abiotic approaches. In this perspective, we articulate the scientific an…
View article: History of and Aftermath from the Withdrawal of the Intermediate-Range Nuclear Forces Treaty
History of and Aftermath from the Withdrawal of the Intermediate-Range Nuclear Forces Treaty Open
On February 1, 2019, the United States and Russia withdrew from the three-decades old Intermediate-Range Nuclear Forces (INF) treaty. Events precipitating the withdrawal were allegations by both the United States and Russia of a variety of…
View article: Molecular Pharming to Support Human Life on the Moon, Mars, and Beyond
Molecular Pharming to Support Human Life on the Moon, Mars, and Beyond Open
Space missions have always assumed that the risk of spacecraft malfunction far outweighs the risk of human system failure. This assumption breaks down for longer duration exploration missions and exposes vulnerabilities in space medical sy…