Aaron J. Deutsch
YOU?
Author Swipe
View article: Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score
Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score Open
Objective Polygenic scores strongly predict type 1 diabetes risk, but most scores were developed in European-ancestry populations. In this study, we developed a multi-ancestry polygenic score to accurately predict type 1 diabetes risk acro…
View article: Standardized Measurement of Type 1 Diabetes Polygenic Risk Across Multiancestry Population Cohorts
Standardized Measurement of Type 1 Diabetes Polygenic Risk Across Multiancestry Population Cohorts Open
free access, no CC license
View article: Type 1 Diabetes Polygenic Scores Improve Diagnostic Accuracy in Pediatric Diabetes Care
Type 1 Diabetes Polygenic Scores Improve Diagnostic Accuracy in Pediatric Diabetes Care Open
Background Accurately classifying pediatric diabetes can be challenging for providers, and misclassification can result in suboptimal care. In recent years, type 1 diabetes (T1D) polygenic scores, which quantify one’s genetic risk for T1D …
View article: Standardized Measurement of Type 1 Diabetes Polygenic Risk Across Multi-Ancestry Population Cohorts
Standardized Measurement of Type 1 Diabetes Polygenic Risk Across Multi-Ancestry Population Cohorts Open
Type 1 diabetes (T1D) polygenic risk scores (PRS) are effective tools for discriminating T1D from other diabetes types and predicting T1D risk, with applications in screening and intervention trials. A previously published T1D Genetic Risk…
View article: Identification of Immune Checkpoint Inhibitor–Induced Diabetes
Identification of Immune Checkpoint Inhibitor–Induced Diabetes Open
Importance Immune checkpoint inhibitors (ICIs) have revolutionized cancer care; however, accompanying immune-related adverse events (irAEs) confer substantial morbidity and occasional mortality. Life-threatening irAEs may require permanent…
View article: Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis
Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis Open
Background Precision medicine has the potential to improve cardiovascular disease (CVD) risk prediction in individuals with Type 2 diabetes (T2D). Methods We conducted a systematic review and meta-analysis of longitudinal studies to identi…
View article: 1252 Immune checkpoint inhibitor-induced diabetes mellitus comprises multiple clinical endotypes with distinct immunologic features
1252 Immune checkpoint inhibitor-induced diabetes mellitus comprises multiple clinical endotypes with distinct immunologic features Open
Background Immune checkpoint inhibitor-induced diabetes mellitus (ICI-DM) is a rare adverse effect of ICI therapy, presumably caused by immune-mediated destruction of insulin-producing pancreatic β-cells. ICI-DM carries significant mortali…
View article: Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity
Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity Open
We identified genetic subtypes of type 2 diabetes (T2D) by analyzing genetic data from diverse groups, including non-European populations. We implemented soft clustering with 650 T2D-associated genetic variants, capturing known and novel T…
View article: Disease-modifying therapies and features linked to treatment response in type 1 diabetes prevention: a systematic review
Disease-modifying therapies and features linked to treatment response in type 1 diabetes prevention: a systematic review Open
Background Type 1 diabetes (T1D) results from immune-mediated destruction of insulin-producing beta cells. Prevention efforts have focused on immune modulation and supporting beta cell health before or around diagnosis; however, heterogene…
View article: The use of precision diagnostics for monogenic diabetes: a systematic review and expert opinion
The use of precision diagnostics for monogenic diabetes: a systematic review and expert opinion Open
Background Monogenic diabetes presents opportunities for precision medicine but is underdiagnosed. This review systematically assessed the evidence for (1) clinical criteria and (2) methods for genetic testing for monogenic diabetes, summa…
View article: Participant characteristics in the prevention of gestational diabetes as evidence for precision medicine: a systematic review and meta-analysis
Participant characteristics in the prevention of gestational diabetes as evidence for precision medicine: a systematic review and meta-analysis Open
Background Precision prevention involves using the unique characteristics of a particular group to determine their responses to preventive interventions. This study aimed to systematically evaluate the participant characteristics associate…
View article: Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity
Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity Open
We identified genetic subtypes of type 2 diabetes (T2D) by analyzing genetic data from diverse groups, including non-European populations. We implemented soft clustering with 650 T2D-associated genetic variants, capturing known and novel T…