Aaron L. Brown
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View article: Spatial Variations in Shear Stress Activate klf2a-snai1b Signaling for Bicuspid to Multicuspid Valve Formation
Spatial Variations in Shear Stress Activate klf2a-snai1b Signaling for Bicuspid to Multicuspid Valve Formation Open
Bicuspid aortic valve (BAV) is the most common congenital heart defect, involving heterogenous contributions from multiple genes and signaling pathways. In zebrafish hearts, the atrioventricular (AV) valve undergoes a transition from 2 cus…
View article: Mechanically Activated snai1b Coordinates the Initiation of Myocardial Delamination for Trabeculation
Mechanically Activated snai1b Coordinates the Initiation of Myocardial Delamination for Trabeculation Open
During development, myocardial contractile force and intracardiac hemodynamic shear stress coordinate the initiation of trabeculation. While Snail family genes are well-recognized transcription factors of epithelial-to-mesenchymal transiti…
View article: Mechanically activated snai1b coordinates the initiation of myocardial delamination for trabeculation
Mechanically activated snai1b coordinates the initiation of myocardial delamination for trabeculation Open
During development, myocardial contractile force and intracardiac hemodynamic shear stress coordinate the initiation of trabeculation. While Snail family genes are well-recognized transcription factors of epithelial-to-mesenchymal transiti…
View article: A Fluid-Structure Interaction Model of the Zebrafish Aortic Valve
A Fluid-Structure Interaction Model of the Zebrafish Aortic Valve Open
The zebrafish is a valuable model organism for studying cardiac development and diseases due to its many shared aspects of genetics and anatomy with humans and ease of experimental manipulations. Computational fluid-structure interaction (…
View article: A software benchmark for cardiac elastodynamics
A software benchmark for cardiac elastodynamics Open
In cardiovascular mechanics, reaching consensus in simulation results within a physiologically relevant range of parameters is essential for reproducibility purposes. Although currently available benchmarks contain some of the features tha…
View article: A Modular Framework for Implicit 3D-0D Coupling in Cardiac Mechanics
A Modular Framework for Implicit 3D-0D Coupling in Cardiac Mechanics Open
In numerical simulations of cardiac mechanics, coupling the heart to a model of the circulatory system is essential for capturing physiological cardiac behavior. A popular and efficient technique is to use an electrical circuit analogy, kn…
View article: Selective Deletion of the Mechanistic Target of Rapamycin From the Renal Collecting Duct Principal Cell in Mice Down-Regulates the Epithelial Sodium Channel
Selective Deletion of the Mechanistic Target of Rapamycin From the Renal Collecting Duct Principal Cell in Mice Down-Regulates the Epithelial Sodium Channel Open
The mechanistic target of rapamycin (mTOR), a serine-threonine-specific kinase, is a cellular energy sensor, integrating growth factor and nutrient signaling. In the collecting duct (CD) of the kidney, the epithelial sodium channel (ENaC) …
View article: Mechanistic target of rapamycin: integrating growth factor and nutrient signaling in the collecting duct
Mechanistic target of rapamycin: integrating growth factor and nutrient signaling in the collecting duct Open
The renal collecting duct and other postmacula densa sites are the primary tubular regions for fine-tuning of electrolyte homeostasis in the body. A role for the mechanistic target of rapamycin (mTOR), a serine-threonine kinase, has recent…