Aaron McClelland
YOU?
Author Swipe
View article: miR-214 and Its Primary Transcript <i>Dnm3os</i> Regulate Fibrosis and Inflammation Through RAGE Signaling in Diabetic Kidney Disease
miR-214 and Its Primary Transcript <i>Dnm3os</i> Regulate Fibrosis and Inflammation Through RAGE Signaling in Diabetic Kidney Disease Open
Pathologic signaling via the receptor for advanced glycation end products (RAGE) is critical to diabetic kidney disease (DKD) development, whereas RAGE deletion is renoprotective. Noncoding RNAs (ncRNAs), including miRNAs, also play key ro…
View article: <b>miR-214 and its primary transcript Dnm3os</b><b> </b><b>regulate fibrosis and inflammation through RAGE signalling in</b><b> diabetic kidney disease</b>
<b>miR-214 and its primary transcript Dnm3os</b><b> </b><b>regulate fibrosis and inflammation through RAGE signalling in</b><b> diabetic kidney disease</b> Open
Pathological signaling via the receptor for advanced glycation end-products (RAGE) is critical in diabetic kidney disease (DKD) development, while RAGE deletion is reno-protective. Non-coding RNAs (ncRNAs), including microRNAs (miRs), also…
View article: Timeliness metrics for screening and preventing TB in household contacts of pulmonary TB patients in Kenya
Timeliness metrics for screening and preventing TB in household contacts of pulmonary TB patients in Kenya Open
BACKGROUND: The study assessed whether a “7-1-7” timeliness metric for screening and TB preventive therapy (TPT) could be implemented for household contacts (HHCs) of index patients with bacteriologically confirmed pulmonary TB under routi…
View article: Nuclear Expression and DNA Binding Capacity of Receptor for Advanced Glycation End Products in Renal Tissue
Nuclear Expression and DNA Binding Capacity of Receptor for Advanced Glycation End Products in Renal Tissue Open
The AGER gene encodes for a number of RAGE isoforms, with the membrane bound signal transduction and “decoy” circulating soluble RAGE being the best characterised. Here we demonstrate a novel nuclear isoform of RAGE in mice and human kidne…
View article: Lipoxins Regulate the Early Growth Response–1 Network and Reverse Diabetic Kidney Disease
Lipoxins Regulate the Early Growth Response–1 Network and Reverse Diabetic Kidney Disease Open
Background The failure of spontaneous resolution underlies chronic inflammatory conditions, including microvascular complications of diabetes such as diabetic kidney disease. The identification of endogenously generated molecules that prom…
View article: MicroRNA-21 in diabetic nephropathy and a cross-sectional analysis of the role of TGFβ in proximal tubule epithelial cells and mesangial cells
MicroRNA-21 in diabetic nephropathy and a cross-sectional analysis of the role of TGFβ in proximal tubule epithelial cells and mesangial cells Open
Diabetic nephropathy (DN) is the leading cause of renal failure in much of the world. It is a complex disease resulting in pathological changes in various cell types and ultimately culminating in end-stage renal disease. Specifically, mesa…