Aaron Morawski
YOU?
Author Swipe
View article: 632 NC410 in combination with pembrolizumab improves anti-tumor responses by promoting collagen remodeling and tumor immunity in advanced ICI naïve MSS/MSI-L colorectal cancer (CRC)
632 NC410 in combination with pembrolizumab improves anti-tumor responses by promoting collagen remodeling and tumor immunity in advanced ICI naïve MSS/MSI-L colorectal cancer (CRC) Open
View article: Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway
Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway Open
View article: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway
GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway Open
View article: LAIR-1 agonism as a therapy for acute myeloid leukemia
LAIR-1 agonism as a therapy for acute myeloid leukemia Open
Effective eradication of leukemic stem cells (LSCs) remains the greatest challenge in treating acute myeloid leukemia (AML). The immune receptor LAIR-1 has been shown to regulate LSC survival; however, the therapeutic potential of this pat…
View article: 748 A phase 1/2, open-label, dose-escalation, safety and tolerability study of NC762 in subjects with advanced or metastatic solid tumors
748 A phase 1/2, open-label, dose-escalation, safety and tolerability study of NC762 in subjects with advanced or metastatic solid tumors Open
Background NC762 is a humanized IgG1κ monoclonal antibody that targets human B7-H4 (B7 homolog 4), a transmembrane protein, associated with the B7 family of molecules known for their immunomodulatory functions. While limited expression is …
View article: 739 A phase 1b/2, open-label, safety, tolerability and efficacy study of NC410 plus pembrolizumab for participants with immune checkpoint inhibitor (ICI) refractory, or MSS/MSI-low ICI naïve advanced or metastatic solid tumors
739 A phase 1b/2, open-label, safety, tolerability and efficacy study of NC410 plus pembrolizumab for participants with immune checkpoint inhibitor (ICI) refractory, or MSS/MSI-low ICI naïve advanced or metastatic solid tumors Open
Background The tumor extracellular matrix (ECM) functions as a physical barrier to immune cell infiltration and acts to directly inhibit immune cells by interacting with the inhibitory receptor, Leukocyte Associated Immunoglobulin-Like Rec…
View article: 490 Clinical benefit through Siglec-15 targeting with NC318 antibody in subjects with Siglec-15 positive advanced solid tumors
490 Clinical benefit through Siglec-15 targeting with NC318 antibody in subjects with Siglec-15 positive advanced solid tumors Open
Background Siglec-15 (S15) is a member of the Siglec family of immunoglobulin superfamily proteins involved in immune regulation. NC318 is a first-in-class humanized IgG1κ monoclonal antibody that blocks S15-mediated immune suppression. Me…
View article: 487 NC410, a fusion protein of LAIR-2 (Leukocyte Associated Immunoglobulin-like Receptor) with human IgG1 Fc, is safe & tolerable with evidence of immune modulation in subjects with advanced solid tumors
487 NC410, a fusion protein of LAIR-2 (Leukocyte Associated Immunoglobulin-like Receptor) with human IgG1 Fc, is safe & tolerable with evidence of immune modulation in subjects with advanced solid tumors Open
Background Collagen and C1q in the extracellular matrix (ECM), are the predominant ligands for LAIR-1, an inhibitory receptor expressed on the cell surface of several immune cell subsets that inhibits immune activation and migration. LAIR-…
View article: Human immunodeficiency reveals GIMAP5 as lymphocyte-specific regulator of senescence
Human immunodeficiency reveals GIMAP5 as lymphocyte-specific regulator of senescence Open
Elucidating the molecular basis of immunodeficiency diseases is a powerful approach to discovering new immunoregulatory pathways in humans. Here we report 10 affected individuals from 4 families with a new immunodeficiency disease comprisi…
View article: Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease
Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease Open
X-linked immunodeficiency with magnesium defect, EBV infection, and neoplasia (XMEN) disease are caused by deficiency of the magnesium transporter 1 (MAGT1) gene. We studied 23 patients with XMEN, 8 of whom were EBV naive. We observed lymp…
View article: CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis
CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis Open
CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy (the CHAPLE syndrome) is caused by abnormal complement activation due to biallelic loss-of-function mutations in CD55. (Funded by th…
View article: Genomic determinants of chronic myelomonocytic leukemia
Genomic determinants of chronic myelomonocytic leukemia Open
View article: Large Deletion of MAGT1 Gene in a Patient with Classic Kaposi Sarcoma, CD4 Lymphopenia, and EBV Infection
Large Deletion of MAGT1 Gene in a Patient with Classic Kaposi Sarcoma, CD4 Lymphopenia, and EBV Infection Open
EBNA Epstein-Barr nuclear antigenTo the Editor Kaposi sarcoma (KS) in children is rare and generally associated with loss of CD4+ T cells in human immunodeficiency virus (HIV) infected patients and impaired immunity to human herpes virus 8…
View article: Reprogramming of Polycomb-Mediated Gene Silencing in Embryonic Stem Cells by the miR-290 Family and the Methyltransferase Ash1l
Reprogramming of Polycomb-Mediated Gene Silencing in Embryonic Stem Cells by the miR-290 Family and the Methyltransferase Ash1l Open
View article: Assessing Transmissible Spongiform Encephalopathy Species Barriers with an <em>In Vitro</em> Prion Protein Conversion Assay
Assessing Transmissible Spongiform Encephalopathy Species Barriers with an <em>In Vitro</em> Prion Protein Conversion Assay Open
Studies to understanding interspecies transmission of transmissible spongiform encephalopathies (TSEs, prion diseases) are challenging in that they typically rely upon lengthy and costly in vivo animal challenge studies. A number of in vit…