Aaron Odell
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View article: Ancestral Chromosome-Level Assemblies Reveal Posthybridization Genome Evolution in the New Mexico Whiptail Lizard ( <i>Aspidoscelis neomexicanus</i> )
Ancestral Chromosome-Level Assemblies Reveal Posthybridization Genome Evolution in the New Mexico Whiptail Lizard ( <i>Aspidoscelis neomexicanus</i> ) Open
Unisexual species of whiptail lizards in the genus Aspidoscelis arose by interspecific hybridization. They reproduce clonally through parthenogenesis and are thought to maintain the fixed heterozygosity that resulted from their hybrid orig…
Why we need all the organisms: an exploration of the Monarch knowledge graph to aid mechanism discovery Open
Research done using model organisms has been fundamental to the biological understanding of human genes, diseases and phenotypes. Model organisms provide tractable systems for experiments to enhance understanding of biological mechanisms c…
Koza and Koza-Hub for born-interoperable knowledge graph generation using KGX Open
Knowledge graph construction has become an essential domain for the future of biomedical research. But current approaches demand a high amount of redundant labor. These redundancies are the result of the lack of data standards and "knowled…
Towards a standard benchmark for phenotype-driven variant and gene prioritisation algorithms: PhEval - Phenotypic inference Evaluation framework Open
PhEval and the standardised test corpora solve the issues of patient data availability and experimental tooling configuration when benchmarking and comparing rare disease VGPAs. By providing standardised data on patient cohorts from real-w…
View article: Post-meiotic mechanism of facultative parthenogenesis in gonochoristic whiptail lizard species
Post-meiotic mechanism of facultative parthenogenesis in gonochoristic whiptail lizard species Open
Facultative parthenogenesis (FP) has historically been regarded as rare in vertebrates, but in recent years incidences have been reported in a growing list of fish, reptile, and bird species. Despite the increasing interest in the phenomen…
View article: Post-meiotic mechanism of facultative parthenogenesis in gonochoristic whiptail lizard species
Post-meiotic mechanism of facultative parthenogenesis in gonochoristic whiptail lizard species Open
Facultative parthenogenesis (FP) has historically been regarded as rare in vertebrates, but in recent years incidences have been reported in a growing list of fish, reptile, and bird species. Despite the increasing interest in the phenomen…
Systems genetics analysis of the LXS recombinant inbred mouse strains:Genetic and molecular insights into acute ethanol tolerance Open
We have been using the Inbred Long- and Short-Sleep mouse strains (ILS, ISS) and a recombinant inbred panel derived from them, the LXS, to investigate the genetic underpinnings of acute ethanol tolerance which is considered to be a risk fa…
Transcriptome and Functional Profile of Cardiac Myocytes Is Influenced by Biological Sex Open
Background— Although cardiovascular disease is the primary killer of women in the United States, women and female animals have traditionally been omitted from research studies. In reports that do include both sexes, significant sexual dimo…
A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response Open
The human Mediator complex regulates RNA polymerase II transcription genome-wide. A general factor that regulates Mediator function is the four-subunit kinase module, which contains either cyclin-dependent kinase 8 (CDK8) or CDK19. Whereas…
Genome characterization of the selected long- and short-sleep mouse lines Open
The Inbred Long- and Short-Sleep (ILS, ISS) mouse lines were selected for differences in acute ethanol sensitivity using the loss of righting response (LORR) as the selection trait. The lines show an over tenfold difference in LORR and, al…