Aaron R. J. Hutton
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View article: Author Correction: Microneedle-based biosensing
Author Correction: Microneedle-based biosensing Open
View article: Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs
Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs Open
The safety of repeated microarray patch (MAP) application is crucial for its development as an innovative drug delivery platform. This study is the first to assess the safety of repeated applications of hydrogel‐forming, dissolving, and im…
View article: Lyophilised reservoirs in combination with hydrogel-forming microarray patches for transdermal delivery of isoniazid and pyridoxine hydrochloride
Lyophilised reservoirs in combination with hydrogel-forming microarray patches for transdermal delivery of isoniazid and pyridoxine hydrochloride Open
View article: A State‐of‐the‐Art Appraisal of Nanomaterials in Microneedles in the Delivery of Therapeutics and Vaccines
A State‐of‐the‐Art Appraisal of Nanomaterials in Microneedles in the Delivery of Therapeutics and Vaccines Open
Nanomaterial‐loaded microneedles are a novel development in the fields of medicine and vaccines. Researchers have created extremely effective systems for the targeted and controlled delivery of a variety of bioactive agents by fusing nanom…
View article: Application of microarray patches for the transdermal administration of psychedelic drugs in micro-doses
Application of microarray patches for the transdermal administration of psychedelic drugs in micro-doses Open
View article: Evaluation of physical and chemical modifications to drug reservoirs for stimuli-responsive microneedles
Evaluation of physical and chemical modifications to drug reservoirs for stimuli-responsive microneedles Open
View article: Transdermal delivery of bisphosphonates using dissolving and hydrogel-forming microarray patches: Potential for enhanced treatment of osteoporosis
Transdermal delivery of bisphosphonates using dissolving and hydrogel-forming microarray patches: Potential for enhanced treatment of osteoporosis Open
View article: Risperidone-cyclodextrin complex reservoir combined with hydrogel-forming microneedle array patches for enhanced transdermal delivery
Risperidone-cyclodextrin complex reservoir combined with hydrogel-forming microneedle array patches for enhanced transdermal delivery Open
Hydrogel-forming microneedle array patches (HFMAPs) are microneedles that create microconduits upon insertion and swelling in the skin, potentially allowing prolonged drug delivery without generating sharps waste. Delivering hydrophobic dr…
View article: Dissolving microarray patches for transdermal delivery of risperidone for schizophrenia management
Dissolving microarray patches for transdermal delivery of risperidone for schizophrenia management Open
Schizophrenia is a psychiatric disorder that results from abnormal levels of neurotransmitters in the brain. Risperidone (RIS) is a common drug prescribed for the treatment of schizophrenia. RIS is a hydrophobic drug that is typically admi…
View article: Transdermal Delivery of Pramipexole Using Microneedle Technology for the Potential Treatment of Parkinson’s Disease
Transdermal Delivery of Pramipexole Using Microneedle Technology for the Potential Treatment of Parkinson’s Disease Open
Parkinson's disease (PD) is a debilitating neurodegenerative disease primarily impacting neurons responsible for dopamine production within the brain. Pramipexole (PRA) is a dopamine agonist that is currently available in tablet form. Howe…
View article: Improved pharmacokinetic and lymphatic uptake of Rose Bengal after transfersome intradermal deposition using hollow microneedles
Improved pharmacokinetic and lymphatic uptake of Rose Bengal after transfersome intradermal deposition using hollow microneedles Open
The lymphatic system is active in several processes that regulate human diseases, among which cancer progression stands out. Thus, various drug delivery systems have been investigated to promote lymphatic drug targeting for cancer therapy;…
View article: Transdermal Administration of Nanobody Molecules using Hydrogel‐Forming Microarray Patch Technology: A Unique Delivery Approach
Transdermal Administration of Nanobody Molecules using Hydrogel‐Forming Microarray Patch Technology: A Unique Delivery Approach Open
Nanobody molecules, derived from heavy‐chain only antibodies in camelids, represent the next generation of biotherapeutics. In addition to low immunogenicity, high stability, and potency, their single‐domain format facilitates the construc…
View article: Design of a Novel Delivery Efficiency Feedback System for Biphasic Dissolving Microarray Patches Based on Poly(Lactic Acid) and Moisture‐Indicating Silica
Design of a Novel Delivery Efficiency Feedback System for Biphasic Dissolving Microarray Patches Based on Poly(Lactic Acid) and Moisture‐Indicating Silica Open
Dissolving microarray patches (DMAPs) represent an innovative approach to minimally invasive transdermal drug delivery, demonstrating efficacy in delivering both small and large therapeutic molecules. However, concerns raised in end‐user s…
View article: Intradermal delivery of the antiretroviral drugs cabotegravir and rilpivirine by dissolving microarray patches: Investigation of lymphatic uptake
Intradermal delivery of the antiretroviral drugs cabotegravir and rilpivirine by dissolving microarray patches: Investigation of lymphatic uptake Open
View article: Novel SmartReservoirs for hydrogel-forming microneedles to improve the transdermal delivery of rifampicin
Novel SmartReservoirs for hydrogel-forming microneedles to improve the transdermal delivery of rifampicin Open
SmartReservoirs (SRs) are novel drug-reservoirs for hydrogel-forming microneedles (HF-MNs). SRs improved rifampicin solubility and diffusion through the HF-matrix, thereby enhancing the transdermal permeation of the poorly soluble antibiot…
View article: Delivering hydrosoluble compounds through the skin: what are the chances?
Delivering hydrosoluble compounds through the skin: what are the chances? Open
The epidermis, according to its structure and composition, represents the essential obstacle to the penetration of hydrosoluble drugs, lowering the possibility of being administered by a skin-related route, including epidermal, dermal and …
View article: Long-acting microneedle formulations
Long-acting microneedle formulations Open
View article: Fabrication and characterisation of poly(sulfonated) and poly(sulfonic acid) dissolving microneedles for delivery of antibiotic and antifungal agents
Fabrication and characterisation of poly(sulfonated) and poly(sulfonic acid) dissolving microneedles for delivery of antibiotic and antifungal agents Open
Skin and soft tissue infections (SSTIs) arise from microbial ingress into the skin. In this study, poly(2-acrylamido-2-methyl-1-propanesulfonic acid) (polyAMPS), which has been reported to exhibit antimicrobial properties was synthesised f…
View article: Microarray patches for managing infections at a global scale
Microarray patches for managing infections at a global scale Open
View article: Formulation of antiretroviral nanocrystals and development into a microneedle delivery system for potential treatment of HIV-associated neurocognitive disorder (HAND)
Formulation of antiretroviral nanocrystals and development into a microneedle delivery system for potential treatment of HIV-associated neurocognitive disorder (HAND) Open
View article: Development and Evaluation of Dissolving Microarray Patches for Co-administered and Repeated Intradermal Delivery of Long-acting Rilpivirine and Cabotegravir Nanosuspensions for Paediatric HIV Antiretroviral Therapy
Development and Evaluation of Dissolving Microarray Patches for Co-administered and Repeated Intradermal Delivery of Long-acting Rilpivirine and Cabotegravir Nanosuspensions for Paediatric HIV Antiretroviral Therapy Open
View article: Enhancing the Transdermal Delivery of ‘Next Generation’ Variable New Antigen Receptors Using Microarray Patch Technology: a Proof-of-Concept Study
Enhancing the Transdermal Delivery of ‘Next Generation’ Variable New Antigen Receptors Using Microarray Patch Technology: a Proof-of-Concept Study Open
Heavy chain only binding proteins, such as variable new antigen receptors (VNARs), have emerged as an alternative to the highly successful therapeutic monoclonal antibodies (mAb). Owing to their small size (∼ 11 kDa) and single chain only …
View article: The Role of 3D Printing Technology in Microengineering of Microneedles
The Role of 3D Printing Technology in Microengineering of Microneedles Open
Microneedles (MNs) are minimally invasive devices, which have gained extensive interest over the past decades in various fields including drug delivery, disease diagnosis, monitoring, and cosmetics. MN geometry and shape are key parameters…
View article: HPLC-MS method for simultaneous quantification of the antiretroviral agents rilpivirine and cabotegravir in rat plasma and tissues
HPLC-MS method for simultaneous quantification of the antiretroviral agents rilpivirine and cabotegravir in rat plasma and tissues Open
View article: Bioinspired microneedle patches: Biomimetic designs, fabrication, and biomedical applications
Bioinspired microneedle patches: Biomimetic designs, fabrication, and biomedical applications Open
This is the unformatted version of the accepted review paper manuscript "Bioinspired microneedle patches: Biomimetic designs, fabrication, and biomedical applications" published on Matter, 5(2): 390 (2022), by P. Makvandi*†, A. Maleki†, M.…
View article: Bioinspired microneedle patches: Biomimetic designs, fabrication, and biomedical applications
Bioinspired microneedle patches: Biomimetic designs, fabrication, and biomedical applications Open
View article: Designing a unique feedback mechanism for hydrogel-forming microneedle array patches: a concept study
Designing a unique feedback mechanism for hydrogel-forming microneedle array patches: a concept study Open
View article: Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion
Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion Open
View article: Engineering Microneedle Patches for improved Penetration: Analysis, Skin Models, and Factors Affecting Needle Insertion
Engineering Microneedle Patches for improved Penetration: Analysis, Skin Models, and Factors Affecting Needle Insertion Open
Review Paper Type - Final Published Version ABSTRACT: Transdermal microneedle (MN) patches are a promising tool used to transport a wide variety of active compounds into the skin. To serve as a substitute for common hypodermic needles, MNs…
View article: Microneedle Mediated Transdermal Delivery of Protein, Peptide and Antibody Based Therapeutics: Current Status and Future Considerations
Microneedle Mediated Transdermal Delivery of Protein, Peptide and Antibody Based Therapeutics: Current Status and Future Considerations Open