Aaron S. Devanathan
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View article: Cardiovascular‐Kidney‐Metabolic Syndrome in People With <scp>HIV</scp> : An Emerging Frontier for Clinical Pharmacology
Cardiovascular‐Kidney‐Metabolic Syndrome in People With <span>HIV</span> : An Emerging Frontier for Clinical Pharmacology Open
As antiretroviral therapy (ART) prolongs lifespans, people with HIV (PWH) face a new syndemic: Cardiovascular‐Kidney‐Metabolic (CKM) syndrome. Yet CKM in PWH is poorly characterized. Inflammation, complex pharmacokinetic (PK) alterations, …
View article: Individual differences in the pharmacokinetic profiling of ∆9-THC may be associated with differential motivational effects of ∆9-THC on cognitive performance.
Individual differences in the pharmacokinetic profiling of ∆9-THC may be associated with differential motivational effects of ∆9-THC on cognitive performance. Open
Cannabis is the most widely used illicit substance in the United States, and its use is increasing with the recent push for legalization and decriminalization, as well as the growing use for medicinal purposes. While cannabis can have posi…
View article: Pharmacokinetics of long‐acting cabotegravir and rilpivirine in seminal plasma throughout the dosing interval
Pharmacokinetics of long‐acting cabotegravir and rilpivirine in seminal plasma throughout the dosing interval Open
View article: Sustained virologic suppression of multidrug-resistant HIV in an individual treated with anti-CD4 domain 1 antibody and lenacapavir
Sustained virologic suppression of multidrug-resistant HIV in an individual treated with anti-CD4 domain 1 antibody and lenacapavir Open
View article: Lenacapavir: Playing the Long Game in the New Era of Antiretrovirals
Lenacapavir: Playing the Long Game in the New Era of Antiretrovirals Open
The mainstay of antiretroviral therapy (ART) has been combination oral therapy. While oral ART is highly effective, nonadherence remains a chief concern. Addressing this concern in recent years is the emergence of long‐acting antiretrovira…
View article: Estimating and Explaining the Differences in Health Care Seeking by Symptom Burden Among Persons With Presumptive Tuberculosis: Findings From a Population-Based Tuberculosis Prevalence Survey in a High-Burden Setting in India
Estimating and Explaining the Differences in Health Care Seeking by Symptom Burden Among Persons With Presumptive Tuberculosis: Findings From a Population-Based Tuberculosis Prevalence Survey in a High-Burden Setting in India Open
Background There is a lack of research evidence on the quantitative relationship between symptom burden and health care seeking among individuals with presumptive tuberculosis (TB). Methods Data were derived from a cross-sectional populati…
View article: Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method to quantify antiretroviral drug concentrations in human plasma for therapeutic monitoring
Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method to quantify antiretroviral drug concentrations in human plasma for therapeutic monitoring Open
View article: Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method for quantifying lenacapavir plasma concentrations: Application to therapeutic monitoring
Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method for quantifying lenacapavir plasma concentrations: Application to therapeutic monitoring Open
View article: Activation of PXR causes drug interactions with Paxlovid in transgenic mice
Activation of PXR causes drug interactions with Paxlovid in transgenic mice Open
View article: Metabolism-guided development of Ko143 analogs as ABCG2 inhibitors
Metabolism-guided development of Ko143 analogs as ABCG2 inhibitors Open
View article: A Novel Algorithm to Improve PrEP Adherence Monitoring Using Dried Blood Spots
A Novel Algorithm to Improve PrEP Adherence Monitoring Using Dried Blood Spots Open
Tenofovir diphosphate (TFVdp; an active metabolite of oral HIV pre‐exposure prophylaxis (PrEP)) is measured in dried blood spots (DBS) to estimate adherence. However, TFVdp's long half‐life in whole blood may lead to misclassification foll…
View article: Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Fibrosis in the Spleens of Nonhuman Primates
Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Fibrosis in the Spleens of Nonhuman Primates Open
This is the accepted manuscript version of the work published in its final form as Devanathan, A. S., White, N. R., Desyaterik, Y., Gabriela De la Cruz., Nekorchuk, M., Terry, M., Busman-Sahay, K., Adamson, L., Luciw, P., Fedoriw, Y., Este…
View article: Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Fibrosis in the Spleens of Nonhuman Primates
Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Fibrosis in the Spleens of Nonhuman Primates Open
Although current antiretroviral therapy (ART) has increased life expectancy, a cure for human immunodeficiency virus (HIV) remains elusive due to the persistence of the virus in tissue reservoirs. In the present study, we sought to elucida…
View article: How‐to guide for overcoming barriers of research and scholarship training in Pharm.D. and pharmacy residency programs
How‐to guide for overcoming barriers of research and scholarship training in Pharm.D. and pharmacy residency programs Open
Accrediting bodies for Doctor of Pharmacy (Pharm.D.) and postgraduate residency training programs recognize the importance of research and scholarship training. However, specific guidance on how research and scholarship fundamentals should…
View article: Pharmacology of HIV Cure: Site of Action
Pharmacology of HIV Cure: Site of Action Open
Despite significant advances in HIV treatment over the past 30 years, critical barriers to an HIV cure persist. The HIV reservoir, defined at both the cellular and anatomical level, constitutes the main barrier to cure. While the mechanism…
View article: Human Immunodeficiency Virus Persistence in the Spleen: Opportunities for Pharmacologic Intervention
Human Immunodeficiency Virus Persistence in the Spleen: Opportunities for Pharmacologic Intervention Open
The persistence of HIV in the spleen, despite combination antiretroviral therapy, is not well understood. Sustained immune dysregulation and delayed immune recovery, in addition to immune cell exhaustion, may contribute to persistence of i…
View article: Efficacy, pharmacokinetics and neurocognitive performance of dual, NRTI-sparing antiretroviral therapy in acute HIV-infection
Efficacy, pharmacokinetics and neurocognitive performance of dual, NRTI-sparing antiretroviral therapy in acute HIV-infection Open
Objectives: The aim of this study was to evaluate penetration of antiretrovirals into compartments and efficacy of a dual, NRTI-sparing regimen in acute HIV infection (AHI). Design: Single-arm, open-label pilot study of participants with A…
View article: Antiretroviral Penetration and Drug Transporter Concentrations in the Spleens of Three Preclinical Animal Models and Humans
Antiretroviral Penetration and Drug Transporter Concentrations in the Spleens of Three Preclinical Animal Models and Humans Open
Adequate antiretroviral (ARV) concentrations in lymphoid tissues are critical for optimal antiretroviral therapy (ART). While the spleen contains 25% of the body’s lymphocytes, there are minimal data on ARV penetration in this organ. This …
View article: Antiretroviral Penetration across Three Preclinical Animal Models and Humans in Eight Putative HIV Viral Reservoirs
Antiretroviral Penetration across Three Preclinical Animal Models and Humans in Eight Putative HIV Viral Reservoirs Open
For HIV cure strategies like “kick and kill” to succeed, antiretroviral (ARV) drugs must reach effective concentrations in putative viral reservoirs. We characterize penetration of six ARVs in three preclinical animal models and humans. We…
View article: The Effect of Veno-Arterial Extracorporeal Oxygenation and Nasogastric Tube Administration on the Pharmacokinetic Profile of Abacavir, Lamivudine and Dolutegravir: A Case Report
The Effect of Veno-Arterial Extracorporeal Oxygenation and Nasogastric Tube Administration on the Pharmacokinetic Profile of Abacavir, Lamivudine and Dolutegravir: A Case Report Open
Background Pharmacokinetic (PK) changes can affect antiretroviral (ARV) systemic exposure for critically ill patients living with HIV (CI-PLWH). Studies to guide ARV adjustments in this population are limited. Methods A PK analysis was con…