Aaron Simoni
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View article: Obesity promotes urinary tract infection by disrupting bladder focal adhesion kinase signaling
Obesity promotes urinary tract infection by disrupting bladder focal adhesion kinase signaling Open
Obesity is a significant public health concern associated with numerous health risks. Infections are a major complication of obesity, but the mechanisms driving increased infection risk remain unclear. Using a diet-induced obesity mouse mo…
View article: PTEN modulates urinary tract infection susceptibility and shapes urothelial antibacterial defenses
PTEN modulates urinary tract infection susceptibility and shapes urothelial antibacterial defenses Open
Despite advancements in our understanding of urinary tract infection (UTI) pathogenesis, UTIs remain a leading cause of morbidity, partly because of an incomplete understanding of the molecular pathways governing bladder antibacterial defe…
View article: Obesity promotes urinary tract infection by disrupting urothelial immune defenses
Obesity promotes urinary tract infection by disrupting urothelial immune defenses Open
Obesity is a significant public health concern that is associated with numerous health risks. Infections are a major complication of obesity, but the mechanisms responsible for increased infection risk are poorly defined. Here, we use a di…
View article: Insulin receptor orchestrates kidney antibacterial defenses
Insulin receptor orchestrates kidney antibacterial defenses Open
Urinary tract infection (UTI) commonly afflicts people with diabetes. This augmented infection risk is partly due to deregulated insulin receptor (IR) signaling in the kidney collecting duct. The collecting duct is composed of intercalated…
View article: Current and emerging strategies to curb antibiotic-resistant urinary tract infections
Current and emerging strategies to curb antibiotic-resistant urinary tract infections Open
View article: Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection
Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection Open
View article: Tubular mitochondrial pyruvate carrier disruption elicits redox adaptations that protect from acute kidney injury
Tubular mitochondrial pyruvate carrier disruption elicits redox adaptations that protect from acute kidney injury Open
View article: Tubular Mitochondrial Pyruvate Carrier Disruption Elicits Redox Adaptations that Protect from Acute Kidney Injury
Tubular Mitochondrial Pyruvate Carrier Disruption Elicits Redox Adaptations that Protect from Acute Kidney Injury Open
Energy-intensive kidney reabsorption processes essential for normal whole-body function are maintained by tubular epithelial cell metabolism. Tubular metabolism changes markedly following acute kidney injury (AKI), but which changes are ad…
View article: Repurposing HDAC inhibitors to enhance ribonuclease 4 and 7 expression and reduce urinary tract infection
Repurposing HDAC inhibitors to enhance ribonuclease 4 and 7 expression and reduce urinary tract infection Open
With the emergence of antibiotic-resistant bacteria, innovative approaches are needed for the treatment of urinary tract infections. Boosting antimicrobial peptide expression may provide an alternative to antibiotics. Here, we developed re…
View article: Ribonuclease 7 polymorphism rs1263872 reduces antimicrobial activity and associates with pediatric urinary tract infections
Ribonuclease 7 polymorphism rs1263872 reduces antimicrobial activity and associates with pediatric urinary tract infections Open
Ribonuclease 7 (RNase 7) is an antimicrobial peptide that prevents urinary tract infections (UTI); however, it is yet unknown how RNASE7 genetic variations affect its antimicrobial activity and its mitigation of UTI risk. This study determ…