Aaron T. Butt
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View article: The <i>Burkholderia cenocepacia</i> iron starvation σ factor, OrbS, possesses an on-board iron sensor
The <i>Burkholderia cenocepacia</i> iron starvation σ factor, OrbS, possesses an on-board iron sensor Open
Burkholderia cenocepacia is an opportunistic pathogen that causes severe infections of the cystic fibrosis (CF) lung. To acquire iron, B. cenocepacia secretes the Fe(III)-binding compound, ornibactin. Genes for synthesis and utilisation of…
View article: Distinct Modes of Promoter Recognition by Two Iron Starvation σ Factors with Overlapping Promoter Specificities
Distinct Modes of Promoter Recognition by Two Iron Starvation σ Factors with Overlapping Promoter Specificities Open
ECF σ factors regulate subsets of bacterial genes in response to environmental stress signals by directing RNA polymerase to promoter sequences known as the −35 and −10 elements. In this work, we identify the −10 and −35 elements that are …
View article: Corrigendum: Iron Acquisition Mechanisms and Their Role in the Virulence of Burkholderia Species
Corrigendum: Iron Acquisition Mechanisms and Their Role in the Virulence of Burkholderia Species Open
CORRECTION article Front. Cell. Infect. Microbiol., 24 August 2018Sec. Molecular Bacterial Pathogenesis Volume 8 - 2018 | https://doi.org/10.3389/fcimb.2018.00305
View article: Iron Acquisition Mechanisms and Their Role in the Virulence of Burkholderia Species
Iron Acquisition Mechanisms and Their Role in the Virulence of Burkholderia Species Open
Burkholderia is a genus within the β-Proteobacteriaceae that contains at least 90 validly named species which can be found in a diverse range of environments. A number of pathogenic species occur within the genus. These inclu…
View article: An efficient system for the generation of marked genetic mutants in members of the genus Burkholderia
An efficient system for the generation of marked genetic mutants in members of the genus Burkholderia Open
To elucidate the function of a gene in bacteria it is vital that targeted gene inactivation (allelic replacement) can be achieved. Allelic replacement is often carried out by disruption of the gene of interest by insertion of an antibiotic…
View article: Trehalase plays a role in macrophage colonization and virulence of<i>Burkholderia pseudomallei</i>in insect and mammalian hosts
Trehalase plays a role in macrophage colonization and virulence of<i>Burkholderia pseudomallei</i>in insect and mammalian hosts Open
Trehalose is a disaccharide formed from two glucose molecules. This sugar molecule can be isolated from a range of organisms including bacteria, fungi, plants and invertebrates. Trehalose has a variety of functions including a role as an e…