Aaron R. Wheeler
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View article: A digital microfluidic approach to increasing sample volume and reducing bead numbers in single molecule array assays
A digital microfluidic approach to increasing sample volume and reducing bead numbers in single molecule array assays Open
Digital microfluidics enables processing of large sample volumes (up to 100 μL) with low bead counts (as few as 5000) in single molecule array assays.
View article: A combined digital microfluidic test for assessing infection and immunity status for viral disease in saliva
A combined digital microfluidic test for assessing infection and immunity status for viral disease in saliva Open
This study presents an automated digital microfluidic platform capable of simultaneously detecting SARS-CoV-2 infection (spike protein) and immune response markers (IgG and IgA) in saliva with high sensitivity and specificity.
View article: A compartmentalization-free microfluidic digital assay for detecting picogram levels of protein analytes
A compartmentalization-free microfluidic digital assay for detecting picogram levels of protein analytes Open
This work introduces a compartmentalization-free digital detection technique that enhances sensitivity for detecting low-abundance proteins in an automated microfluidic format.
Distinct Proteomic Brain States Underlying Long-Term Memory Formation in Aversive Operant Conditioning Open
Long-term memory (LTM) formation relies on de novo protein synthesis; however, the full complement of proteins crucial to LTM formation remains unknown in any system. Using an aversive operant conditioning model of aerial respiratory behav…
View article: MarketGPT: Developing a Pre-trained transformer (GPT) for Modeling Financial Time Series
MarketGPT: Developing a Pre-trained transformer (GPT) for Modeling Financial Time Series Open
This work presents a generative pre-trained transformer (GPT) designed for modeling financial time series. The GPT functions as an order generation engine within a discrete event simulator, enabling realistic replication of limit order boo…
View article: Droplet-Based Microfluidics with Mass Spectrometry for Microproteomics
Droplet-Based Microfluidics with Mass Spectrometry for Microproteomics Open
Microproteomics, the profiling of protein expressions in small cell populations or individual cells, is essential for understanding complex biological systems. However, sample loss and insufficient sensitivity of analytical techniques pose…
Toward Analysis at the Point of Need: A Digital Microfluidic Approach to Processing Multi‐Source Sexual Assault Samples Open
Forensic case samples collected in sexual assaults typically contain DNA from multiple sources, which complicates short‐tandem repeat (STR) profiling. These samples are typically sent to a laboratory to separate the DNA from sperm and non‐…
View article: Integrating<i>in silico</i>predictions with an engineered tissue assay identifies Perlecan as an age-perturbed re-quiescence cue for muscle stem cells
Integrating<i>in silico</i>predictions with an engineered tissue assay identifies Perlecan as an age-perturbed re-quiescence cue for muscle stem cells Open
Skeletal muscle regeneration is mediated by resident muscle stem cells that produce progeny to repair or recreate muscle. Critical to this function is the ability to transition between states of proliferation and quiescence. This balancing…
The laminar position, morphology, and gene expression profiles of cortical astrocytes are influenced by time of birth from ventricular/subventricular progenitors Open
Astrocytes that reside in superficial (SL) and deep cortical layers have distinct molecular profiles and morphologies, which may underlie specific functions. Here, we demonstrate that the production of SL and deep layer (DL) astrocyte popu…
View article: Scalable Agent-Based Modeling for Complex Financial Market Simulations
Scalable Agent-Based Modeling for Complex Financial Market Simulations Open
In this study, we developed a computational framework for simulating large-scale agent-based financial markets. Our platform supports trading multiple simultaneous assets and leverages distributed computing to scale the number and complexi…
WITHDRAWN: Digital microfluidics as an emerging tool for bacterial protocols Open
The Publisher regrets that this article is an accidental duplication of an article previously published at http://dx.doi.org/10.1016/j.slast.2022.10.001. This duplication was due to an error in the publishing workflow and was not the respo…
Digital microfluidics with distance-based detection – a new approach for nucleic acid diagnostics Open
We introduce the integration of digital microfluidics (DMF) with distance-based detection (DBD). This platform allows for miniaturized diagnosis of infectious diseases in a format that is easy to operate with a detection scheme that can be…
View article: Pre-concentration by liquid intake by paper (PCLIP): a new technique for large volumes and digital microfluidics
Pre-concentration by liquid intake by paper (PCLIP): a new technique for large volumes and digital microfluidics Open
Microfluidic platforms are an attractive option for incorporating complex fluid handling into low-cost and rapid diagnostic tests. A persistent challenge for microfluidics, however, is the mismatch in the "world-tochip" interface - it is c…
View article: Pre-concentration by liquid intake by paper (PCLIP): a new technique for large volumes and digital microfluidics
Pre-concentration by liquid intake by paper (PCLIP): a new technique for large volumes and digital microfluidics Open
Microfluidic platforms are an attractive option for incorporating complex fluid handling into low-cost and rapid diagnostic tests. A persistent challenge for microfluidics, however, is the mismatch in the "world-tochip" interface - it is c…
All-in-One digital microfluidics pipeline for proteomic sample preparation and analysis Open
The All-in-One digital microfluidic pipeline allows for end-to-end automation of processing and analysis of mass-limited proteomic samples.
Correction: Virtual microwells for digital microfluidic reagent dispensing and cell culture Open
Correction for ‘Virtual microwells for digital microfluidic reagent dispensing and cell culture’ by Irwin A. Eydelnant et al. , Lab Chip , 2012, 12 , 750–757, https://doi.org/10.1039/C2LC21004E.
Introduction to <i>Lab on a Chip</i> Reviews issue Open
Aaron R. Wheeler and Philippa Ross introduce the first Lab on a Chip Reviews issue.
View article: Use of a rapid digital microfluidics-powered immunoassay for assessing measles and rubella infection and immunity in outbreak settings in the Democratic Republic of the Congo
Use of a rapid digital microfluidics-powered immunoassay for assessing measles and rubella infection and immunity in outbreak settings in the Democratic Republic of the Congo Open
The Democratic Republic of the Congo (DRC) has a high measles incidence despite elimination efforts and has yet to introduce rubella vaccine. We evaluated the performance of a prototype rapid digital microfluidics powered (DMF) enzyme-link…
Monitoring non-specific adsorption at solid–liquid interfaces by supercritical angle fluorescence microscopy Open
Supercritical angle fluorescence (SAF) microscopy is a novel imaging tool based on the use of distance-dependent fluorophore emission patterns to provide accurate locations of fluorophores relative to a surface. This technique has been ext…
Digital microfluidics as an emerging tool for bacterial protocols Open
Bacteria are widely studied in various research areas, including synthetic biology, sequencing and diagnostic testing. Protocols involving bacteria are often multistep, cumbersome and require access to a long list of instruments to perform…
Translating diagnostics and drug delivery technologies to low-resource settings Open
Diagnostics and drug delivery technologies engineered for low-resource settings aim to meet their technical design specifications using strategies that are compatible with limited equipment, infrastructure, and operator training. Despite m…
Monitoring Non-Specific Adsorption at Solid-Liquid Interfaces by Supercritical Angle Fluorescence Microscopy Open
Supercritical angle fluorescence (SAF) microscopy is a novel imaging tool based on the use of distance-dependent fluorophore emission patterns to provide accurate locations of fluorophores relative to a surface. This technique has been use…
Structure-Property-Performance Relationships of Cuprous Oxide Nanostructures for Dielectric Mie Resonance-Enhanced Photocatalysis Open
Nanostructured metal oxides, such as Cu2O, CeO2, α-Fe2O3, and TiO2 can efficiently mediate photocatalysis for solar-to-chemical energy conversion and pollution remediation. In this contribution, we report a novel approach, dielectric Mie r…
Dielectric Mie Resonance-Enhanced Photocatalysis on Cuprous Oxide Nanostructures Open
Nanostructured metal oxides, such as Cu2O, CeO2, {\alpha}-Fe2O3, and TiO2 can efficiently mediate photocatalysis for solar-to-chemical energy conversion and pollution remediation. In this contribution, we report a novel approach, dielectri…
Reconfigurable multi-component micromachines driven by optoelectronic tweezers Open
There is great interest in the development of micromotors which can convert energy to motion in sub-millimeter dimensions. Micromachines take the micromotor concept a step further, comprising complex systems in which multiple components wo…