Aaron Wise
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View article: Longitudinal patterns and predictors of response to standard-of-care therapy in lupus nephritis: data from the Accelerating Medicines Partnership Lupus Network
Longitudinal patterns and predictors of response to standard-of-care therapy in lupus nephritis: data from the Accelerating Medicines Partnership Lupus Network Open
Background Leveraging the Accelerating Medicines Partnership (AMP) Lupus Nephritis (LN) dataset, we evaluated longitudinal patterns, rates, and predictors of response to standard-of-care therapy in patients with lupus nephritis. Methods Pa…
View article: Adrenergic signaling controls early transcriptional programs during CD8+ T cell responses to viral infection
Adrenergic signaling controls early transcriptional programs during CD8+ T cell responses to viral infection Open
Norepinephrine is a key sympathetic neurotransmitter, which acts to suppress CD8 + T cell cytokine secretion and lytic activity by signaling through the β2-adrenergic receptor (ADRB2). Although ADRB2 signaling is considered generally immun…
View article: Adrenergic signaling controls early transcriptional programs during CD8<sup>+</sup> T cell responses to viral infection
Adrenergic signaling controls early transcriptional programs during CD8<sup>+</sup> T cell responses to viral infection Open
Viral infections drive the expansion and differentiation of responding CD8 + T cells into variegated populations of cytolytic effector and memory cells. While pro-inflammatory cytokines and cell surface immune receptors play a key role in …
View article: β-Cleavage of the prion protein in the human eye: Implications for the spread of infectious prions and human ocular disorders
β-Cleavage of the prion protein in the human eye: Implications for the spread of infectious prions and human ocular disorders Open
View article: Release of Iron-Loaded Ferritin in Sodium Iodate-Induced Model of Age Related Macular Degeneration: An In-Vitro and In-Vivo Study
Release of Iron-Loaded Ferritin in Sodium Iodate-Induced Model of Age Related Macular Degeneration: An In-Vitro and In-Vivo Study Open
In this report, we evaluated the role of iron in sodium iodate (NaIO3)-induced model of age-related macular degeneration (AMD) in ARPE-19 cells in-vitro, and mouse models in-vivo. ARPE-19 cells, a human retinal pigmented epithelial cell li…
View article: Upregulation of Local Hepcidin Contributes to Iron Accumulation in Alzheimer’s Disease Brains
Upregulation of Local Hepcidin Contributes to Iron Accumulation in Alzheimer’s Disease Brains Open
Background: Accumulation of iron is a consistent feature of Alzheimer’s disease (AD) brains. The underlying cause, however, remains debatable. Objective: To explore whether local hepcidin synthesized by brain cells contributes to iron accu…
View article: ARPE19 cells exposed to sodium iodate accumulate ferritin in lysosomes and release ferritin-rich vesicles in the extracellular milieu: Implications for invitro model of AMD
ARPE19 cells exposed to sodium iodate accumulate ferritin in lysosomes and release ferritin-rich vesicles in the extracellular milieu: Implications for invitro model of AMD Open
View article: HERVs establish a distinct molecular subtype in stage II/III colorectal cancer with poor outcome
HERVs establish a distinct molecular subtype in stage II/III colorectal cancer with poor outcome Open
View article: Upregulation of brain hepcidin in prion diseases
Upregulation of brain hepcidin in prion diseases Open
Accumulation of redox-active iron in human sporadic Creutzfeldt-Jakob disease (sCJD) brain tissue and scrapie-infected mouse brains has been demonstrated previously. Here, we explored whether upregulation of local hepcidin secreted within …
View article: Retinal Degeneration and Alzheimer’s Disease: An Evolving Link
Retinal Degeneration and Alzheimer’s Disease: An Evolving Link Open
Age-related macular degeneration (AMD) and glaucoma are degenerative conditions of the retina and a significant cause of irreversible blindness in developed countries. Alzheimer’s disease (AD), the most common dementia of the elderly, is o…
View article: Publisher Correction: Integrated multi-omics framework of the plant response to jasmonic acid
Publisher Correction: Integrated multi-omics framework of the plant response to jasmonic acid Open
View article: The contrasting roles of hepcidin and prion protein in phototoxic injury to retinal pigment epithelial cells; an in vitro study
The contrasting roles of hepcidin and prion protein in phototoxic injury to retinal pigment epithelial cells; an in vitro study Open
View article: Integrated multi-omics framework of the plant response to jasmonic acid
Integrated multi-omics framework of the plant response to jasmonic acid Open
View article: Development and Analytical Validation of a DNA Dual-Strand Approach for the US Food and Drug Administration–Approved Next-Generation Sequencing–Based Praxis Extended RAS Panel for Metastatic Colorectal Cancer Samples
Development and Analytical Validation of a DNA Dual-Strand Approach for the US Food and Drug Administration–Approved Next-Generation Sequencing–Based Praxis Extended RAS Panel for Metastatic Colorectal Cancer Samples Open
View article: Prion protein modulates endothelial to mesenchyme-like transition in trabecular meshwork cells: Implications for primary open angle glaucoma
Prion protein modulates endothelial to mesenchyme-like transition in trabecular meshwork cells: Implications for primary open angle glaucoma Open
Endothelial-to-mesenchyme-like transition (Endo-MT) of trabecular meshwork (TM) cells is known to be associated with primary open angle glaucoma (POAG). Here, we investigated whether the prion protein (PrP C ), a neuronal protein known to …
View article: Integrated Multi-omic Framework of the Plant Response to Jasmonic Acid
Integrated Multi-omic Framework of the Plant Response to Jasmonic Acid Open
Understanding the systems-level actions of transcriptional responses to hormones provides insight into how the genome is reprogrammed in response to environmental stimuli. Here, we investigate the signaling pathway of the hormone jasmonic …
View article: From Complexity to the Clinic: Patient-based Models of Time Series Gene Expression
From Complexity to the Clinic: Patient-based Models of Time Series Gene Expression Open
Lane Center for Computational Biology
View article: Valuing the effect sizes hypothesized in phase 3 trials of targeted therapies in oncology
Valuing the effect sizes hypothesized in phase 3 trials of targeted therapies in oncology Open
This abstract was not included in this publication as it was already published. See Annals of Oncology, Volume 27, Issue suppl_6, 1 October 2016, 317P (10.1093/annonc/mdw366.02) - Oxford University Press.
View article: A transcription factor hierarchy defines an environmental stress response network
A transcription factor hierarchy defines an environmental stress response network Open
Complex transcription factor interactions To respond to environmental changes, such as drought, plants must regulate numerous cellular processes. Working in the model plant Arabidopsis , Song et al. profiled the binding of 21 transcription…
View article: Predicting Targeted Cancer Therapeutics
Predicting Targeted Cancer Therapeutics Open
Motivation: Cancer is a complex and evolving disease, making it difficult to discover effective treatments. Traditional drug discovery relies on high-throughput screening on reductionist models in order to enable the testing of 10 5 or 10 …
View article: cDREM: Inferring Dynamic Combinatorial Gene Regulation
cDREM: Inferring Dynamic Combinatorial Gene Regulation Open
Genes are often combinatorially regulated by multiple transcription factors (TFs). Such combinatorial regulation plays an important role in development and facilitates the ability of cells to respond to different stresses. While a number o…